Abstract
We evaluated swallowing function in patients with myasthenia gravis (MG) with or without dysphagia symptoms using different evaluation parameters and compared the results with those of healthy subjects. A total of 36 patients with MG and 25 healthy volunteers were included in the study. The subjects were classified into three groups; patients without dysphagia (group 1), patients with dysphagia (group 2), and healthy participants (group 3). The presence and severity of dysphagia, the oropharyngeal, pharyngeal, pharyngoesophageal, and esophageal phases were assessed using a screening test, manometric test, electrophysiologic studies [electroneuromyography (EMG)], fiberoptic endoscopic evaluation of swallowing (FEES), and barium swallow pharyngeal esophagography (BSPE), respectively. There was a significant difference between group 1 and group 3 in terms of BSPE (p = 0.001) and manometry tests (p = 0.001). A significant difference was found in all methods between group 2 and group 3 (p = 0.001, for all). In the comparison of the patient groups, although the number of patients with dysphagia in group 2 was significantly higher in the clinical tests (p = 0.007), FEES (p = 0.001), and EMG (p = 0.043) than in group 1, no difference was detected for BSPE (p = 0.119) and manometry (p = 0.644). Swallowing functions in patients with MG may be affected even without symptoms. This condition should be considered in their follow-up.
Similar content being viewed by others
References
Bettini M, Chaves M, Cristiano E, Pagotto V, Perez L, Giunta D et al (2017) Incidence of autoimmune myasthenia gravis in a health maintenance organization in buenos aires, Argentina. Neuroepidemiology 48(3–4):119–123
Hsu CC, Chen WH, Chiu HC (2013) Using swallow sound and surface electromyography to determine the severity of dysphagia in patients with myasthenia gravis. Biomed Signal Process Control 8(3):237–243
Akaishi T, Suzuki Y, Imai T, Tsuda E, Minami N, Nagane Y et al (2016) Response to treatment of myasthenia gravis according to clinical subtype. BMC Neurol 16:225
Gwathmey KG, Burns TM (2015) Myasthenia gravis. Semin Neurol 35(4):327–339
Ramalho S, Pereira S, Oliveira P, Morais H, Lima N, Condé A (2014) Dysphagia as a presenting symptom of myasthenia gravis-case report. IJOHNS 3:23–25
Juan HC, Tou I, Lo SC, Wu IH (2010) Efficacy of postural techniques assessed by videofluoroscopy for myasthenia gravis with dysphagia as the presenting symptom: a case report. J Med Case Rep 4:370
Rajeshwari A, Somayaji G, Deviprasad S (2011) A rare cause of dysphagia: a case report. Indian J Otolaryngol Head Neck Surg 63:83–84
Breen E, Bleich L, Loeser C (2014) Myasthenia gravis presenting with dysphagia in an elderly male: a case report. Am J Med 127(9):e7–e8
Klair JS, Rochlani YM, Meena NK (2014) Myasthenia gravis masquerading as dysphagia: unveiled by magnesium infusion. BMJ Case Rep. https://doi.org/10.1136/bcr-2014-204163
Suzuki Y (2015) Clinical features and associated conditions of myasthenia gravis. Nihon Rinsho 7:477–481
Altman KW, Richards A, Goldberg L, Frucht S, McCabe DJ (2013) Dysphagia in stroke, neurodegenerative disease, and advanced dementia. Otolaryngol Clin N Am 46(6):1137–1149
Ertekin C, Yüceyar N, Aydogdu I (1998) Clinical and electrophysiological evaluation of dysphagia in myasthenia gravis. J Neurol Neurosurg Psychiatry 65(6):848–856
Linke R, Witt TN, Tatsch K (2003) Assessment of esophageal function in patients with myasthenia gravis. J Neurol 250(5):601–606
Joshita Y, Yoshida M, Yoshida Y, Kimura K (1990) Manometric study of the pharynx and pharyngoesophageal sphincter in myasthenia gravis. Rinsho Shinkeigaku 30(9):944–951
Huang MH, King KL, Chien KY (1998) Esophageal manometric studies in patients with myasthenia gravis. J Thorac Cardiovasc Surg 95(2):281–285
Desuter G, Van Parijs V, Gardiner Q (2015) Megaesophagus associated with myasthenia gravis: a rare condition in humans. B-ENT 11(1):63–66
Coscarelli S, Verrecchia L, Coscarelli A (2007) Endoscopic evaluation of neurological dysphagic patients. Acta Otorhinolaryngol Ital 27(6):281–285
Higo R, Nito T, Tayama N (2005) Videofluoroscopic assessment of swallowing function in patients with myasthenia gravis. J Neurol Sci 231(1–2):45–48
Oda AL, Chiappetta AL, Annes M, Marchesan IQ, Oliveira AS (2002) Clinical, endoscopical and manometric evaluation of swallowing in patients with acquired autoimmune myasthenia gravis. Arq Neuropsiquiatr 60(4):986–995
Colton-Hudson A, Koopman WJ, Moosa T, Smith D, Bach D, Nicolle M (2002) A prospective assessment of the characteristics of dysphagia in myasthenia gravis. Dysphagia 17(2):147–151
Aoki Y, Yamamoto T, Ogata K, Oya Y, Ogawa M, Murata M (2007) Videofluorographic evaluation of dysphagia in a patient with myasthenia gravis. Rinsho Shinkeigaku 47(10):669–671
Hou LZ, Xu W, Han DM, Zhang L, Jing Y (2007) Laryngopharyngeal characteristics of myasthenia gravis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 42(4):263–267
Sanders DB, Wolfe GI, Benatar M, Evoli A, Gilhus NE, Illa I et al (2016) International consensus guidance for management of myasthenia gravis. Neurology 87:1–7
Belafsky PC, Mouadeb DA, Rees CJ, Pryor JC, Postma GN, Allen J et al (2008) Validity and reliability of the eating assessment tool (EAT-10). Ann Otol Rhinol Laryngol 117:919–924
Dziewas R, Warnecke T, Olenberg S, Teismann I, Zimmermann J, Kramer C (2008) Towards a basic endoscopic assessment of swallowing in acute stroke-development and evaluation of a simple dysphagia score. Cerebrovasc Dis 26(1):41–47
Umay EK, Unlu E, Saylam GK, Cakcı A, Korkmaz H (2013) Evaluation of dysphagia in early stroke patients by bedside, endoscopic and electrophysiological methods. Dysphagia 28(3):395–403
Pandolfino JE, Ghosh SK, Rice J, Clarke JO, Kwiatek MA, Kahrilas PJ (2007) Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controls. Am J Gastroenterol 102:1–11
Shaw SM, Martino R (2013) The normal swallow muscular and neurophysiological control. Otolaryngol Clin N Am 46:937–956
Matsuo K, Palmer JB (2008) Anatomy and physiology of feeding and swallowing—normal and abnormal. Phys Med Rehabil Clin N Am 19(4):691–707
Xu W, Han D, Hou L, Hu R, Wang L (2009) Clinical and electrophysiological characteristics of larynx in myasthenia gravis. Ann Otol Rhinol Laryngol 118(9):656–661
Llabre’s M, Molina-Martinez FJ, Miralles F (2005) Dysphagia as the sole manifestation of myasthenia gravis. J Neurol Neurosurg Psychiatry 6:1297–1300
Goyal RK, Chaudhury A (2008) Physiology of normal esophageal motility. J Clin Gastroenterol 42(5):610–619
Funding
There is no funding source in this study.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Umay, E.K., Karaahmet, F., Gurcay, E. et al. Dysphagia in myasthenia gravis: the tip of the Iceberg. Acta Neurol Belg 118, 259–266 (2018). https://doi.org/10.1007/s13760-018-0884-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13760-018-0884-1