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The Impact of Sunlight on Skin Aging

  • Dermatology and Wound Care (C Sayed and D Culton, Section Editors)
  • Published:
Current Geriatrics Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

In this review, we summarize and discuss the current literature on photoaging. We focus on the molecular effects of UV radiation, and the histological and clinical features of chronically sun-exposed skin.

Recent Findings

The expression of numerous proteins is altered in habitually sun-exposed skin, including sirtuins and hedgehog signaling proteins. Pharmacological manipulation of the levels of these proteins can potentially downregulate the photoaging process.

Summary

Mitochondrial and nuclear DNA damage, reactive oxygen species (ROS) production, and altered gene expression patterns are critical components of both photoaging and chronological aging. Chronic UVA and UVB exposure result in the photoaged phenotype through distinct molecular mechanisms, with UVA being primarily ROS-mediated and UVB being DNA damage-mediated. Molecular effects result in an altered dermal and epidermal environment that manifests as the photoaged phenotype. Importantly, skin phototype and environmental influences impact individual responses to chronic UV radiation.

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Authors and Affiliations

  1. Wayne State University School of Medicine, Detroit, MI, USA

    Hisham Kaddurah & Gautham Vellaichamy

  2. Department of Dermatology, Henry Ford Hospital, 3031 West Grand Blvd, Suite 800, Detroit, MI, 48202, USA

    Taylor L. Braunberger, Gautham Vellaichamy, Amanda F. Nahhas, Henry W. Lim & Iltefat H. Hamzavi

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  1. Hisham Kaddurah
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  2. Taylor L. Braunberger
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  4. Amanda F. Nahhas
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  6. Iltefat H. Hamzavi
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Correspondence to Iltefat H. Hamzavi.

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Conflict of Interest

Taylor Braunberger is a sub-investigator for Bayer, Estee Lauder, Unigen, and Ferndale. Amanda Nahhas is a sub-investigator for Bayer, Estee Lauder, Unigen, and Ferndale. Iltefat Hamzavi is an investigator for Incyte Corporation, Bayer, Estee Lauder, Unigen, and Ferndale. Henry Lim is a co-investigator for Allergen, Estee Lauder, Incyte, and Ferndale. Hisham Kaddurah and Gautham Vellaichamy state no conflicts of interest.

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This article is part of the Topical Collection on Dermatology and Wound Care

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Kaddurah, H., Braunberger, T.L., Vellaichamy, G. et al. The Impact of Sunlight on Skin Aging. Curr Geri Rep 7, 228–237 (2018). https://doi.org/10.1007/s13670-018-0262-0

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