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Effect of hemodialysis on circulating cystatin c levels in patients with end stage renal disease

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Abstract

Plasma cystatin C is an emerging parameter to assess kidney function. Its utility in assessing the adequacy of hemodialysis in patients with end-stage-renal disease has however not been established with certainty. This study was therefore carried out to assess the usefulness of serum cystatin C estimation in patients undergoing low flux membrane hemodialysis. Serum creatinine and cystatin C were estimated in 20 patients before and after undergoing hemodialysis. The mean serum creatinine decreased from a pre-dialysis value of 7.72 mg/dL to a post-dialysis value of 2.90 mg/dL. On the contrary, the mean serum cystatin C levels were found to increase from a pre-dialysis value of 5.97 mg/L to a post-dialysis value of 8.25 mg/L. Therefore, serum cystatin C cannot be used to monitor dialysis adequacy. It however, serves as a surrogate marker of the inadequacy of low flux membrane bicarbonate hemodialysis in clearing low molecular weight proteins from the circulation.

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Authors and Affiliations

  1. Department of Biotechnology, Sathyabama University, Chennai, India

    N. Krishnamurthy, K. Arumugasamy & V. Aruna

  2. Department of Biochemistry, PSG Institute of Medical Sciences and Research, Coimbatore, India

    U. Anand & C. V. Anand

  3. Department of Nephrology, PSG Institute of Medical Sciences and Research, Coimbatore, India

    G. Venu

  4. Department of Molecular Biotechnology, Washington University, Washington DC, USA

    R. Gayathri

  5. Department of Biochemistry, PSG Institute of Medical Sciences and Research, Coimbatore, 641004, India

    C. V. Anand

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  1. N. Krishnamurthy
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  2. K. Arumugasamy
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  3. U. Anand
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  4. C. V. Anand
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  5. V. Aruna
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  6. G. Venu
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  7. R. Gayathri
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Correspondence to C. V. Anand.

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Krishnamurthy, N., Arumugasamy, K., Anand, U. et al. Effect of hemodialysis on circulating cystatin c levels in patients with end stage renal disease. Indian J Clin Biochem 25, 43–46 (2010). https://doi.org/10.1007/s12291-010-0009-y

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  • DOI: https://doi.org/10.1007/s12291-010-0009-y

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