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RBC membrane composition in insulin dependent diabetes mellitus in context of oxidative stress

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Abstract

Glyco-oxidation is considered as a source of permanent, cumulative, oxidative damage to long lived proteins in ageing and in diabetes. Although RBC depends solely on glucose for energy purpose, hyperglycemic state glycosylates hemoglobin, creates oxidative stress and puts the cellular components at risk. In view of this, RBC membrane composition was analyzed in diabetic patients. The results were compared with healthy age and sex matched control groups. When RBC membrane components such as protein, sialic acid, phospholipids and cholesterol were determined in insulin dependent diabetes mellitus, a significant rise in phospholipids and cholesterol and significant fall in sialic acid and protein content was noted. RBC membrane composition showed pronounced alterations in insulin dependent diabetes mellitus. These changes were accompanied by higher levels of lipid peroxidation products like Malondialdehyde.

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Authors and Affiliations

  1. Department of Biochemistry, Topiwala National Medical College and B.Y.L.Nair Hospital, Mumbai Central, Mumbai, 400 008, India

    Gauri S. Vahalkar & Vijaya A. Haldankar

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  1. Gauri S. Vahalkar
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  2. Vijaya A. Haldankar
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Correspondence to Vijaya A. Haldankar.

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Vahalkar, G.S., Haldankar, V.A. RBC membrane composition in insulin dependent diabetes mellitus in context of oxidative stress. Indian J Clin Biochem 23, 223–226 (2008). https://doi.org/10.1007/s12291-008-0050-2

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