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Red Cell Distribution Width as a Marker of Periprocedural Myocardial Infarction in Patients with Elective Percutaneous Coronary Intervention

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Abstract

We aimed to investigate whether red cell distribution width (RDW) was associated with periprocedural myocardial infarction (PMI) in patients undergoing elective percutaneous coronary intervention (PCI). Among 1723 consecutive patients undergoing elective PCI, a total of 230 (13.3%) met the diagnostic criteria of PMI. The high RDW (≥ 12.6%) group tended to have PMI (15.4% vs. 11.2%, P = 0.010). RDW was an independent predictor of PMI whether as a categorical variable (adjusted odds ratio = 1.442, 95% confidence interval = 1.088 to 1.911, P = 0.011) or a continuous variable (adjusted odds ratio = 1.236, 95% confidence interval = 1.079 to 1.415, P = 0.002). High RDW was also significantly associated with increased risk of major adverse cardiovascular events (MACE) during follow-up. However, anemia was not independently associated with PMI or MACE in the current study. In conclusion, RDW showed strong and independent association with PMI in patients undergoing elective PCI.

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Abbreviations

CI:

Confidence interval

CRP:

C-reactive protein

cTnT:

Cardiac troponin T

HR:

Hazard ratio

MACE:

Major adverse cardiovascular events

MCH:

Mean corpuscular hemoglobin

MCHC:

Mean corpuscular hemoglobin concentration

MCV:

Mean corpuscular volume

OR:

Odds ratio

PCI:

Percutaneous coronary intervention

PMI:

Periprocedural myocardial infarction

RDW:

Red cell distribution width

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Funding

This study was supported by the National Natural Science Foundation of China (Grant No: 81970295, 81870267, 81670318 and 81570314), Grant of Shanghai Municipal Commission of Health and Family Planning (Grant No: 2017YQ057), Grant of Shanghai Science and Technology Committee (Grant No: 17411962300), the National Program on Key Basic Research Project of China (973 Program, Grant No: 2014CBA02003), Program for Outstanding Medical Academic Leader (Grant No: 2015-Weijiwei-24), Grant of Zhongshan Hospital Affiliated to Fudan University (Grant No: 2015ZSYXGG07 and 2017ZSYQ08), VG Funding of Clinical Trials (2017-CCA-VG-036), and Merck Funding (Xinxin-merck-fund-051).

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Author notes

  1. Chunfeng Dai and Zhangwei Chen contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China

    Chunfeng Dai, Zhangwei Chen, Juying Qian & Junbo Ge

Authors
  1. Chunfeng Dai
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  2. Zhangwei Chen
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  3. Juying Qian
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Correspondence to Juying Qian.

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The authors declare that they have no conflict of interest.

Human Subjects/Informed Consent Statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. This study was approved by the Ethics Committee of Zhongshan Hospital (Approval No.: B2019-052; Date: 2019-02-28), and informed consent was obtained from all patients for being included in the study.

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Associate Editor Craig M. Stolen oversaw the review of this article

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Dai, C., Chen, Z., Qian, J. et al. Red Cell Distribution Width as a Marker of Periprocedural Myocardial Infarction in Patients with Elective Percutaneous Coronary Intervention. J. of Cardiovasc. Trans. Res. 14, 449–456 (2021). https://doi.org/10.1007/s12265-020-10073-w

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