Abstract
A 61-year-old man was diagnosed with the simultaneous occurrence of chronic myeloid leukemia (CML) and infiltrative intrathoracic plasmacytoma, radiologically mimicking bronchogenic carcinoma. Following the administration of imatinib mesylate (IM; 400 mg/day), both hematologic and partial cytogenetic remission of CML were achieved. However, the pulmonary plasmacytoma was persistently aggravated. High-dose dexamethasone was added to the IM therapy because the patient refused radiotherapy to control the aggravated pulmonary plasmacytoma. Finally, he died due to pneumonia and multi-organ failure during concurrent administration of IM and high-dose dexamethasone.
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References
Nitta M, Tsuboi K, Yamashita S, Kato M, Hayami Y, Harada S, et al. Multiple myeloma preceding the development of chronic myelogenous leukemia. Int J Hematol. 1999;69:170–3.
Galanopoulos A, Papadhimitriou SI, Kritikou-Griva E, Georgiakaki M, Anagnostopoulos NI. Multiple myeloma developing after imatinib mesylate therapy for chronic myeloid leukemia. Ann Hematol. 2009;88:281–2.
Garipidou V, Vakalopoulou S, Tziomalos K. Development of multiple myeloma in a patient with chronic myeloid leukemia after treatment with imatinib mesylate. Oncologist. 2005;10:457–8.
Michael M, Antoniades M, Lemesiou E, Papaminas N, Melanthiou F. Development of multiple myeloma in a patient with chronic myeloid leukemia while on treatment with imatinib mesylate for 65 months. Oncologist. 2009;14:1198–200.
Schwarzmeier JD, Shehata M, Ackermann J, Hilgarth M, Kaufmann H, Drach J. Simultaneous occurrence of chronic myeloid leukemia and multiple myeloma: evaluation by FISH analysis and in vitro expansion of bone marrow cells. Leukemia. 2003;17:1426–8.
Klenn PJ, Hyun BH, Lee YH, Zheng WY. Multiple myeloma and chronic myelogenous leukemia-a case report with literature review. Yonsei Med J. 1993;34:293–300.
Boots MA, Pegrum GD. Simultaneous presentation of chronic granulocytic leukaemia and multiple myeloma. J Clin Pathol. 1982;35:364–5.
Derghazarian C, Whittemore NB. Multiple myeloma superimposed on chronic myelocytic leukemia. Can Med Assoc J. 1974;110:1047–50.
Ide M, Kuwahara N, Matsuishi E, Kimura S, Gondo H. Uncommon case of chronic myeloid leukemia with multiple myeloma. Int J Hematol. 2010;91:699–704.
Pandiella A, Carvajal-Vergara X, Tabera S, Mateo G, Gutierrez N, San Miguel JF. Imatinib mesylate (STI571) inhibits multiple myeloma cell proliferation and potentiates the effect of common antimyeloma agents. Br J Haematol. 2003;123:858–68.
Tzilves D, Gatopoulou A, Zervas K, Katodritou E, Patakiouta F, Tarpagos A, Katsos I. Development of multiple myeloma in a patient with gastrointestinal stromal tumor treated with imatinib mesylate: a case report. World J Gastroenterol. 2007;13:2011–3.
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Kim, H.J., Kim, M.J., Lee, M.J. et al. Coexistence of chronic myeloid leukemia and pulmonary plasmacytoma mimicking primary lung cancer. Int J Hematol 92, 651–654 (2010). https://doi.org/10.1007/s12185-010-0705-7
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DOI: https://doi.org/10.1007/s12185-010-0705-7