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Outcome of Early Stage Pediatric Non-Lymphoblastic Non-Hodgkin Lymphoma

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Abstract

There is lack of data on outcome of limited stage pediatric non-Hodgkin lymphoma (NHL) from south Asia. In view of this lacuna, authors evaluated patients of early stage (stage 1 and 2) non-lymphoblastic pediatric NHL patients treated with uniform short course, reduced-intensity protocol from Jan 2003 through Dec 2016. Of the total 280 subjects with pediatric NHL, 50 were of early stage of which 42 received uniform protocol. B-cell subtype was observed in 83% patients. Event-free-survival (EFS) and overall-survival (OS) were 85% and 90% respectively at 5 y (median-not reached). Age > 13 y emerged as the only poor risk factor for EFS (p = 0.05) on univariate analysis and same had a trend toward inferior prognosis in OS (p = 0.09). Vincristine-induced neuropathy occurred in five patients. Febrile neutropenia was observed in 16% subjects with one patient requiring hospitalization. There was no treatment-related death. This largest data of limited stage pediatric non-lymphoblastic NHL from south Asia highlights that good outcomes may be achieved with less intense short course therapy without hospitalization, and that adolescent age is the only poor prognostic factor for outcome.

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Authors and Affiliations

  1. Department of Medical Oncology, Dr B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, 110029, India

    Amol Patel & Sameer Bakhshi

  2. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

    Mehar Chand Sharma

Authors
  1. Amol Patel
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  2. Mehar Chand Sharma
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  3. Sameer Bakhshi
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Contributions

AP and SB: Manuscript writing, data collection, analysis; MCS: Slides review of all the pathology diagnosis. SB will act as guarantor for this paper.

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Correspondence to Sameer Bakhshi.

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Patel, A., Sharma, M.C. & Bakhshi, S. Outcome of Early Stage Pediatric Non-Lymphoblastic Non-Hodgkin Lymphoma. Indian J Pediatr 85, 782–784 (2018). https://doi.org/10.1007/s12098-017-2585-9

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  • DOI: https://doi.org/10.1007/s12098-017-2585-9

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