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A pathway map of glutamate metabolism

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Journal of Cell Communication and Signaling Aims and scope

Abstract

Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyric aciduria and 5-oxoprolinuria. Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post-translational modifications. This pathway map provides detailed information about enzyme regulation, protein-enzyme interactions, post-translational modifications of enzymes and disorders due to enzyme deficiency. The information included in the map was based on published experimental evidence reported from mammalian systems.

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Abbreviations

PTMs:

Post-translational modifications

ChEBI:

Chemical Entities of Biological Interest

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Acknowledgments

We thank the Department of Biotechnology (DBT), Government of India for research support to the Institute of Bioinformatics, Bangalore. Soujanya D. Yelamanchi is a recipient of a Senior Research Fellowship from the Department of Science and Technology (DST), Government of India. Aafaque Ahmad Khan is a recipient of a Senior Research Fellowship from Indian Council of Medical Research (ICMR).

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Authors and Affiliations

  1. Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India

    Soujanya D. Yelamanchi, Savita Jayaram, Joji Kurian Thomas, Seetaramanjaneyulu Gundimeda, Aafaque Ahmad Khan, Anish Singhal, T. S. Keshava Prasad, B. L. Somani & Harsha Gowda

  2. School of Biotechnology, KIIT University, Bhubaneswar, 751 024, India

    Soujanya D. Yelamanchi, Aafaque Ahmad Khan & Harsha Gowda

  3. Manipal University, Madhav Nagar, Manipal, 576104, India

    Savita Jayaram

  4. Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, 690525, India

    Joji Kurian Thomas

  5. Kasturba Medical College, Manipal University, Mangalore, 576 104, India

    Anish Singhal

  6. YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575 018, India

    T. S. Keshava Prasad & Harsha Gowda

  7. McKusick-Nathans Institute of Genetic Medicine, Baltimore, MD, 21205, USA

    Akhilesh Pandey

  8. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Akhilesh Pandey

  9. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Akhilesh Pandey

  10. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Akhilesh Pandey

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  1. Soujanya D. Yelamanchi
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  2. Savita Jayaram
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  3. Joji Kurian Thomas
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  4. Seetaramanjaneyulu Gundimeda
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  9. B. L. Somani
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Correspondence to B. L. Somani or Harsha Gowda.

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Yelamanchi, S.D., Jayaram, S., Thomas, J.K. et al. A pathway map of glutamate metabolism. J. Cell Commun. Signal. 10, 69–75 (2016). https://doi.org/10.1007/s12079-015-0315-5

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