Abstract
In the recent years, matrix metalloproteinase 9 (MMP-9) has been focused on as an indicator of glioma grade and prognosis, especially in China. However, all results resulted in many conflicts. So, it is necessary to conduct a meta-analysis to secure a convincing correlation between MMP-9 and grade and prognosis. Eligible studies were included via multiple searches, and then odds ratios (ORs) and hazard ratios (HRs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were available for evaluation of publication bias. In addition, heterogeneity and sensitivity were also analyzed. In the present meta-analysis, 23 articles were allowed for inclusion with total 1,635 patients. Coincidentally, all studies were conducted in Chinese populations. High MMP-9 expression in gliomas was closely associated with high WHO grade (III+IV) (n = 22, OR = 5.25, 95 % CI = 4.09–6.73; p = 0.000), while MMP-9 expression did not correlate to age (n = 4, OR = 1.02, 95 % CI = 0.67–1.54; p = 0.929) and gender (n = 5, OR = 0.91, 95 % CI = 0.63–1.33; p = 0.632). Besides, overall survival analysis from two articles revealed MMP-9 expression significantly predicted 5-year-OS (HR = 6.44, 95 % CI = 3.88–10.70; p = 0.000) in glioma patients. No heterogeneity and publication bias were observed across all studies. To conclude, this meta-analysis suggests MMP-9 is potently associated with high grade and poor 5 years prognosis, and MMP-9 test of glioma tissues should be established in department of pathology as a routine in clinical practice.
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20 January 2017
An erratum to this article has been published.
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Acknowledgments
This study was supported by Shandong University Science Technology Innovation Foundation (201410422123). We greatly thank Sera Kwon in Sandy lab for valuable suggestions and writing.
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This article has been retracted at the request of the Editor-in-Chief and the Publisher per the Committee on Publication Ethics guidelines. There is strong reason to believe that the peer review process was compromised and the authors have plagiarized parts from the following article:
Shunzeng Lv, Congxin Dai, Yuting Liu, Ranran Shi, Zhenyu Tang, Mingzhi Han, Ruixiang Bian, Bowen Sun, Renzhi Wang, The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis, Molecular Neurobiology June 2015, Volume 51, Issue 3, pp 1462–1467, DOI:10.1007/s12035-014-8823-5Received: 26 June 2014.
In addition, the article shows similarities with the following article which was submitted within a close timeframe:
Xiangshan Yang, Shunzeng Lv, Xingtong Zhou, Yuting Liu, Daotang Li, Ranran Shi, Huihui Kang, Jing Zhang, Zhongfa Xu, The Clinical Implications of Transforming Growth Factor Beta in Pathological Grade and Prognosis of Glioma Patients: A Meta-Analysis, Molecular Neurobiology August 2015, Volume 52, Issue 1, pp 270–276, DOI: 10.1007/s12035-014-8872-9Received: 6 August 2014.
The article “The Clinical Utility of Matrix Metalloproteinase 9 in Evaluating Pathological Grade and Prognosis of Glioma Patients: A Meta-Analysis” was received: 20 July 2014.
As such the validity of the content of this article cannot be verified.
An erratum to this article is available at https://doi.org/10.1007/s12035-017-0408-7.
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Yang, X., Lv, S., Liu, Y. et al. RETRACTED ARTICLE: The Clinical Utility of Matrix Metalloproteinase 9 in Evaluating Pathological Grade and Prognosis of Glioma Patients: A Meta-Analysis. Mol Neurobiol 52, 38–44 (2015). https://doi.org/10.1007/s12035-014-8850-2
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DOI: https://doi.org/10.1007/s12035-014-8850-2