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Cellular and Molecular Neurobiology of Brain Preconditioning

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Abstract

The tolerant brain which is a consequence of adaptation to repeated nonlethal insults is accompanied by the upregulation of protective mechanisms and the downregulation of prodegenerative pathways. During the past 20 years, evidence has accumulated to suggest that protective mechanisms include increased production of chaperones, trophic factors, and other antiapoptotic proteins. In contrast, preconditioning can cause substantial dampening of the organism’s metabolic state and decreased expression of proapoptotic proteins. Recent microarray analyses have also helped to document a role of several molecular pathways in the induction of the brain refractory state. The present review highlights some of these findings and suggests that a better understanding of these mechanisms will inform treatment of a number of neuropsychiatric disorders.

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Acknowledgments

This paper is supported by the Intramural Research Program of the National Institute on Drug Abuse, NIH, DHHS. The authors also thank the reviewers whose suggestions helped to improve the paper.

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  1. Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA/NIH/DHHS, 251 Bayview Boulevard, Baltimore, MD, 21224, USA

    Jean Lud Cadet & Irina N. Krasnova

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  1. Jean Lud Cadet
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Correspondence to Jean Lud Cadet.

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Cadet, J.L., Krasnova, I.N. Cellular and Molecular Neurobiology of Brain Preconditioning. Mol Neurobiol 39, 50–61 (2009). https://doi.org/10.1007/s12035-009-8051-6

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