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The effective natural compounds for inhibiting Cervical cancer

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Abstract

The secondary compounds found in plants are of great importance in the treatment of many diseases in medicine and pharmacy. Some of these compounds have been reported to exhibit anticarcinogenic effects by inhibiting the growth and metastatic potential of cancer cells. Consumption of the required amount of vegetables and fruits appears to have a protective effect of these secondary compounds on cancer, since most of these drugs are synthesized from natural or natural origin compounds. Secondary compounds in medicinal plants have been found to have an antiproliferative effect by increasing the expression of p53 in cervical cancer cells and decreasing the expression of cyclin D1, one of the cell proliferation markers. The most important step in the fight against cancer is the development of drugs that are selectively targeted against tumor cells and targeting cancer cells to reduce damage to normal cells and prevent the growth and spread of cancer cells. Molecular insertion test is an effective tool for evaluating the bioactivity of possible molecules. In this study, the effect of natural compounds in some medicinal plants in inhibiting cervical cancer, the points where they are effective using docking has been investigated.

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Abbreviations

CQ:

Chloroquine

DADS:

Diallyl disulfide

DAS:

Diallyl sulfide

DATS:

Diallyl trisulfide

TQ:

Thymoquinone

HeLa:

An immortal cell line

JAK2/STAT3:

Activator of transcription 3 signaling pathway

Pt NPs:

A highly efficient and reusable catalyst

Cyclin D1:

An important regulator of cell cycle progression and can function as a transcriptional co-regulator

P53:

Tumor protein Tp63 (also known simply as p63)

SKOV-3:

An ovarian cancer cell line

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Acknowledgements

This work carried out by the Scientific Research Projects of Kırıkkale University [BAP-2016/016,-2017/019, 2018/033].

Funding

The study of the author was supported by Kırıkkale University.

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  1. Education Faculty, Department of Mathematics and Science Education, Science Education, Kırıkkale University, Yahşihan, 71450, Kırıkkale, Turkey

    Faik Gökalp

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Gökalp, F. The effective natural compounds for inhibiting Cervical cancer. Med Oncol 38, 12 (2021). https://doi.org/10.1007/s12032-021-01456-3

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