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Clinicopathological evaluation of Sox10 expression in diffuse-type gastric adenocarcinoma

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Abstract

Sox10, one of the transcription factors, regulates Wnt/β-catenin signaling in diverse developmental processes in normal tissues. Sox10 is also expressed in variable solid tumors such as breast cancer, salivary tumor, hepatocellular carcinoma, ovarian tumor, nasopharyngeal carcinoma, prostate cancer, and digestive cancer. The role of Sox10 during tumorigenesis is still controversial, especially in digestive cancers; thus, we performed clinicopathological evaluation of Sox10 expression in 41 cases of diffuse-type gastric adenocarcinoma (DGA). We examined the expression of Sox10 by immunohistochemical staining and real-time quantitative reverse transcriptase PCR and evaluated the correlation between Sox10 expression and clinicopathological factors. A low-level expression of Sox10 was significantly associated with high-level venous invasion by immunohistochemical evaluation, while it was significantly associated with high-level lymphatic permeation when analyzed by real-time PCR assay. Survival analysis of 41 cases indicated that high level of vascular permeation was a statistically poor prognostic factor, suggesting that derogation of Sox10 would lead to unfavorable patients’ outcome through the acceleration of vascular invasion. In this study, we revealed the clinical benefit of evaluation of Sox10 expression to predict the risk of vascular permeation which yields patients’ poor prognosis in DGA.

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Acknowledgements

Tomoko Takenami, Masana Urushido, Jun Moriya and Jun Suzuka enthusiastically supported us in IHC staining and RT-PCR analysis.

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Authors and Affiliations

  1. Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan

    Marin Kato, Masumi Tsuda, Mishie Ann Tanino & Shinya Tanaka

  2. Department of Translational Pathology, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan

    Hiroshi Nishihara, Taichi Kimura, Lei Wang & Shinya Tanaka

  3. Division of Clinical Cancer Genomics, Hokkaido University Hospital, N14W5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan

    Hiroshi Nishihara & Hideyuki Hayashi

  4. Clinical Research and Medical Innovation Cancer, Hokkaido University Hospital, N14W5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan

    Hiroshi Nishihara, Taichi Kimura & Yusuke Ishida

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  1. Marin Kato
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Correspondence to Hiroshi Nishihara.

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This study was approved by the Medical Ethics Committee of Hokkaido University School of Medicine (15-022).

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Informed consent was obtained from all individual participants included in the study.

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Kato, M., Nishihara, H., Hayashi, H. et al. Clinicopathological evaluation of Sox10 expression in diffuse-type gastric adenocarcinoma. Med Oncol 34, 8 (2017). https://doi.org/10.1007/s12032-016-0865-2

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  • DOI: https://doi.org/10.1007/s12032-016-0865-2

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