Abstract
Introduction
Excessive use of adrenergic agents may result in stunned myocardium.
Cases
We report the cases of two patients with subarachnoid hemorrhage (SAH) complicated by cardiogenic shock secondary to triple-H therapy for cerebral vasospasm. Both patients had normal cardiac function on admission and no signs of acute myocardial infarction at the onset of cardiogenic shock. Intra-aortic balloon pump (IABP) counterpulsation was used to maintain adequate cerebral perfusion while enabling the high doses of norepinephrine that were being administered to be reduced. Reversal of the myocardial dysfunction after vasopressors were discontinued supported a diagnosis of catecholamine-induced stunned myocardium.
Conclusion
IABP counterpulsation may be one therapeutic option for patients with vasospasm after SAH when high doses of vasopressors can induce severe myocardial dysfunction. However, this invasive device may not be sufficient to maintain adequate cerebral perfusion and fatal embolic events can complicate the clinical course.
References
Mayberg MR, Batjer HH, Dacey R, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a statement for health care professionals from a special writing group of the Stroke Council, American Heart Association. Circulation. 1994;90:2592–605.
Van Gijn J, Rinkel GJ. Subarachnoid haemorrhage: diagnosis, causes and management. Brain. 2001;124:249–78. doi:10.1093/brain/124.2.249.
Dumont AS, Dumont RJ, Chow MM, et al. Cerebral vasospasm after subarachnoid hemorrhage: putative role of inflammation. Neurosurgery. 2003;53:123–33. doi:10.1227/01.NEU.0000068863.37133.9E.
Lee KH, Lukovits T, Friedman JA. “Triple-H” therapy for cerebral vasospasm following subarachnoid hemorrhage. Neurocrit Care. 2006;4:68–76. doi:10.1385/NCC:4:1:068.
Suarez JI, Tarr RW, Selman WR. Aneurysmal subarachnoid hemorrhage. N Engl J Med. 2006;354:387–96. doi:10.1056/NEJMra052732.
Donaldson JW, Pritz MB. Myocardial stunning secondary to aneurysmal subarachnoid hemorrhage. Surg Neurol. 2001;55:12–6. doi:10.1016/S0090-3019(00)00296-2.
Bulsara KR, McGirt MJ, Liao L, et al. Use of the peak troponin value to differentiate myocardial infarction from reversible neurogenic left ventricular dysfunction associated with aneurysmal subarachnoid hemorrhage. J Neurosurg. 2003;98:524–8.
Iltumur K, Tamam Y, Karahan Z, Guzel A, Altindag R. Coexisting subarachnoid hemorrhage and subdural hematoma mimicking acute anterolateral myocardial infarction. J Electrocardiol. 2007;40:422–5. doi:10.1016/j.jelectrocard.2007.05.006.
Kono T, Morita H, Kuroiwa T, Onaka H, Takatsuka H, Fujiwara A. Left ventricular wall motion abnormalities in patients with subarachnoid hemorrhage: neurogenic stunned myocardium. J Am Coll Cardiol. 1994;24:636–40.
Sakr YL, Lim N, Amaral AC, et al. Relation of ECG changes to neurological outcome in patients with aneurysmal subarachnoid hemorrhage. Int J Cardiol. 2004;96:369–73. doi:10.1016/j.ijcard.2003.07.027.
Tsuchihashi K, Ueshima K, Uchida T, et al. Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. Angina Pectoris-Myocardial Infarction Investigations in Japan. J Am Coll Cardiol. 2001;38:11–8. doi:10.1016/S0735-1097(01)01316-X.
Jacob WA, Van Bogaert A, Groodt-Lasseel MH. Myocardial ultrastructure and haemodynamic reactions during experimental subarachnoid haemorrhage. J Mol Cell Cardiol. 1972;4:287–98. doi:10.1016/0022-2828(72)90076-4.
Doshi R, Neil-Dwyer G. A clinicopathological study of patients following a subarachnoid hemorrhage. J Neurosurg. 1980;52:295–301.
Sato K, Masuda T, Kikuno T, et al. Left ventricular asynergy and myocardial necrosis accompanied by subarachnoid hemorrhage: contribution of neurogenic pulmonary edema. J Cardiol. 1990;20:359–67.
Bolli R. Mechanism of myocardial “stunning”. Circulation. 1990;82:723–38.
Bolli R, Marban E. Molecular and cellular mechanisms of myocardial stunning. Physiol Rev. 1999;79:609–34.
Jain R, Deveikis J, Thompson BG. Management of patients with stunned myocardium associated with subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2004;25:126–9.
Parekh N, Venkatesh B, Cross D, et al. Cardiac troponin I predicts myocardial dysfunction in aneurysmal subarachnoid hemorrhage. J Am Coll Cardiol. 2000;36:1328–35. doi:10.1016/S0735-1097(00)00857-3.
Chang PC, Lee SH, Hung HF, Kaun P, Cheng JJ. Transient ST elevation and left ventricular asynergy associated with normal coronary artery and Tc-99m PYP Myocardial Infarct Scan in subarachnoid hemorrhage. Int J Cardiol. 1998;63:189–92. doi:10.1016/S0167-5273(97)00293-3.
Pfister D, Strebel SP, Steiner LA. Effects of catecholamines on cerebral blood vessels in patients with traumatic brain injury. Eur J Anaesthesiol Suppl. 2008;42:98–103.
Levy ML, Rabb CH, Zelman V, Giannotta SL. Cardiac performance enhancement from dobutamine in patients refractory to hypervolemic therapy for cerebral vasospasm. J Neurosurg. 1993;79:494–9.
Tavernier B, Decamps F, Vega E, Poidevin P, Verdin M, Riegel B. Systemic treatments of the vasospasm. Ann Fr Anesth Reanim. 2007;26:980–4. doi:10.1016/j.annfar.2007.08.012.
Kassell NF, Helm G, Simmons N, Phillips CD, Cail WS. Treatment of cerebral vasospasm with intra-arterial papaverine. J Neurosurg. 1992;77:848–52.
Higashida RT, Halbach VV, Dowd CF, Dormandy B, Bell J, Hieshima GB. Intravascular balloon dilatation therapy for intracranial arterial vasospasm: patient selection, technique, and clinical results. Neurosurg Rev. 1992;15:89–95. doi:10.1007/BF00313501.
Rosen CL, Sekhar LN, Duong DH. Use of intra-aortic balloon pump counterpulsation for refractory symptomatic vasospasm. Acta Neurochir (Wien). 2000;142:25–32. doi:10.1007/s007010050003.
Boehmer JP, Popjes E. Cardiac failure: mechanical support strategies. Crit Care Med. 2006;34:S268–77. doi:10.1097/01.CCM.0000232490.69771.28.
Yoshitani H, Akasaka T, Kaji S, et al. Effects of intra-aortic balloon counterpulsation on coronary pressure in patients with stenotic coronary arteries. Am Heart J. 2007;154:725–31. doi:10.1016/j.ahj.2007.05.019.
Vijayalakshmi K, Kunadian B, Whittaker VJ, et al. Intra-aortic counterpulsation does not improve coronary flow early after PCI in a high-risk group of patients: observations from a randomized trial to explore its mode of action. J Invasive Cardiol. 2007;19:339–46.
Schreuder JJ, Maisano F, Donelli A, et al. Beat-to-beat effects of intraaortic balloon pump timing on left ventricular performance in patients with low ejection fraction. Ann Thorac Surg. 2005;79:872–80. doi:10.1016/j.athoracsur.2004.07.073.
Dekker AL, Reesink KD, van der Veen FH, et al. Intra-aortic balloon pumping in acute mitral regurgitation reduces aortic impedance and regurgitant fraction. Shock. 2003;19:334–8. doi:10.1097/00024382-200304000-00007.
Simeone FA, Laurent JP, Trepper PJ, Brown DJ, Cotter J. Experimental augmentation of cerebral blood flow by intermittent aortic occlusion. J Neurosurg. 1972;36:700–13.
Nussbaum ES, Heros RC, Solien EE, Madison MT, Sebring LA, Latchaw RE. Intra-aortic balloon counterpulsation augments cerebral blood flow in a canine model of subarachnoid hemorrhage-induced cerebral vasospasm. Neurosurgery. 1995;36:879–84. doi:10.1097/00006123-199504000-00047.
Tranmer BI, Gross CE, Kindt GW, Adey GR. Pulsatile versus nonpulsatile blood flow in the treatment of acute cerebral ischemia. Neurosurgery. 1986;19:724–31.
Cheung AT, Levy WJ, Weiss SJ, Barclay DK, Stecker MM. Relationships between cerebral blood flow velocities and arterial pressures during intra-aortic counterpulsation. J Cardiothorac Vasc Anesth. 1998;12:51–7. doi:10.1016/S1053-0770(98)90055-6.
Gee W, Smith RL, Perline RK, Gallagher HS. Assessment of intra-aortic balloon pumping by ocular pneumoplethysmography. Am Surg. 1986;52:489–91.
Bhayana JN, Scott SM, Sethi GK, Takaro T. Effects of intraaortic balloon pumping on organ perfusion in cardiogenic shock. J Surg Res. 1979;26:108–13. doi:10.1016/0022-4804(79)90086-6.
Brass LM. Reversed intracranial blood flow in patients with an intra-aortic balloon pump. Stroke. 1990;21:484–7.
Nussbaum ES, Sebring LA, Ganz WF, Madison MT. Intra-aortic balloon counterpulsation augments cerebral blood flow in the patient with cerebral vasospasm: a xenon-enhanced computed tomography study. Neurosurgery. 1998;42:206–13. doi:10.1097/00006123-199801000-00048.
Apostolides PJ, Greene KA, Zabramski JM, Fitzgerald JW, Spetzler RF. Intra-aortic balloon pump counterpulsation in the management of concomitant cerebral vasospasm and cardiac failure after subarachnoid hemorrhage: technical case report. Neurosurgery. 1996;38:1056–9. doi:10.1097/00006123-199605000-00042.
Montessuit M, Chevalley C, King J, Faidutti B. The use of intra-aortic counterpulsation balloon for the treatment of cerebral vasospasm and edema. Surgery. 2000;127:230–3. doi:10.1067/msy.2000.102047.
Soehle M, Czosnyka M, Pickard JD, Kirkpatrick PJ. Continuous assessment of cerebral autoregulation in subarachnoid hemorrhage. Anesth Analg. 2004;98:1133–9. doi:10.1213/01.ANE.0000111101.41190.99.
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Taccone, F.S., Lubicz, B., Piagnerelli, M. et al. Cardiogenic Shock with Stunned Myocardium during Triple-H Therapy Treated with Intra-aortic Balloon Pump Counterpulsation. Neurocrit Care 10, 76–82 (2009). https://doi.org/10.1007/s12028-008-9135-2
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DOI: https://doi.org/10.1007/s12028-008-9135-2