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The AP-1 family of transcription factors are important regulators of gene expression within Leydig cells

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Abstract

Purpose

Members of the AP-1 family of transcription factors are immediate early genes being modulated by different extracellular signals. The aim of this review is to highlight the important roles of AP-1 members in transcriptional regulation of genes important for testicular Leydig cell function and male testosterone production.

Methods

A search of the relevant literature was performed in Google Scholar and NCBI Pubmed for AP-1 members and Leydig cells. Additional information was accessed from references of relevant articles. Only primary data from original peer-reviewed articles was considered for this review.

Results

Different signaling pathways important for Leydig cells’ functions are involved in the regulation of the activity of AP-1 members. These transcription factors participate in the regulation of genes related to different biological processes important for Leydig cells.

Conclusions

We conclude that members of the AP-1 family of transcription factors play critical roles in the regulation of Leydig cell proliferation, steroidogenesis, and cell-to-cell communication.

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Current work was funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada (#386557 to L.J.M).

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  1. These authors contributed equally: Ha Tuyen Nguyen, Mustapha Najih

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  1. Biology Department, Université de Moncton, Moncton, NB, E1A 3E9, Canada

    Ha Tuyen Nguyen, Mustapha Najih & Luc J. Martin

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Nguyen, H.T., Najih, M. & Martin, L.J. The AP-1 family of transcription factors are important regulators of gene expression within Leydig cells. Endocrine 74, 498–507 (2021). https://doi.org/10.1007/s12020-021-02888-7

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