Abstract
There is a close relationship between selenium deficiency and Kaschin–Beck disease (KBD). Although the etiology of KBD is not known and selenium deficiency is not its actual cause, it is an important environmental risk factor. In particular, in the Qing-Tibet Plateau, a selenium-deficient region, the prevalence of KBD is serious and still increasing and continues to damage public health. By providing selenium to the population in appropriate amounts, and especially to children, KBD can be effectively controlled and prevented.
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References
Cao J, Li S, Shi Z et al (2008) Articular cartilage metabolism in patients with Kaschin–Beck disease: an endemic osteoarthropathy in China. Osteoarthr Cartil 16(6):680–688
Mathieu F, Begaux F, Lan ZY, Suetens C, Hinsenkamp M (1997) Clinical manifestations of Kaschin–Beck disease in Nyemo Valley, Tibet. Int Orthop 21:151–156
Wang Y, Yang Z, Gilula LA, Zhu C et al (1996) Kaschin–Beck disease: radiographic appearance in the hands and wrist. Radiology 201(1):265–270
Yang JB (1995) Etiology of Kaschin–Beck disease. Chin J Endemiol 14:201–204
Peng A, Wang WH, Wang CX et al (1999) The role of humic substances in drinking water in Kaschin–Beck disease in China. Environ Heal Perspect 107(4):293–296
Suetens C, Moreno-Reyes R, Chasseur C et al (2001) Epidemiological support for a multifactorial etiology of Kaschin–Beck disease in Tibet. Int Orthop 25:180–187
Zhang BJ, Yang LS, Wang WY et al (2010) Quantification and comparison of soil elements in the Tibetan Plateau Kaschin–Beck disease area. Biol Trace Elem Res 138(1–3):68–78
Li SJ, Li W, Hu X et al (2008) Distribution of Kaschin-Beck Disease (KBD) and its relation to selenium content in soil-plant-animal (human being) ecosystem in Tibet. Chin J Ecol 27(12):2167–2170
Zhang B, Yang L, Wang W et al (2011) Environmental selenium in the Kaschin–Beck disease area, Tibetan Plateau, China. Environ Geochem Health 33(5):495–501
Wen H, Wang ZH, Deng SR et al (1990) Investigation report of Kaschin–Beck disease in Xinghai County, Qinghai Province. Chin J Endemiol 9(2):151–154
Li SJ, Yang LS, Wang WY et al (2006) Study on the relationship between selenium concentrations in drinking water and Kaschin–Beck disease in Tibet. Chin J Endemiol 25(4):428–429
Fu Y, Meng FG, Deng JY et al (2010) Investigation on the selenium and T-2 toxin level in Kaschin–Beck disease relative active regions in Aba State of Sichuan Province in (2008). Chin J Endemiol 29(3):325–329
Sun LY, Li Q, Meng FG et al (2012) T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kaschin–Beck disease endemic areas of Qinghai Province. Biol Trace Elem Res 1–3:371–375
Meng FG, Li Q, Yin F et al (2012) Investigation of state and influence factors of children’s Kaschin–Beck disease in Xinghai County of Qinghai Province in 2009. Chin J Endemiol 31(4):426–429
Li SJ, Yang LS, Li YH et al (2006) Relationship between the content of selenium in grains and the Kaschin–Beck disease in Tibet, China. Chin J Endemiol 25(6):673–674
Zhang B, Yang L, Wang W et al (2009) Selenium in environment and its relationship with Kaschin–Beck disease in Rangtang County, Sichuan Province. Prog Geogr 28(6):886–891
Moreno-Reyes R, Suetens C, Mathieu F et al (1998) Kaschin–Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med 339(16):1112–1120
Kang LL, Xu P, Zhaxi SZ et al (2006) The changes of hyalurona, nitric oxide and selenium contents in serum for patients with Kaschin–Beck disease in Tibet. Chin J Endemiol 25(6):694–696
Kang LL, Zhao FC, Yang FY et al (2007) Changes of the content of Se and the levels of several cytokines in the serum of patients with Kaschin–Beck disease. Chin J Cell Mol Immunol 23(6):531–532
Xiao-yan X, Gao Q, Chen Y et al (2012) The selenium nutritional states of the children in Kaschin–Beck disease area in Gangmuda Village, Rangtang County, Sichuan. J China West Normal Univ (Nat Sci) 33(3):78–90
Zhang BJ, Yang LS, Wang WY et al (2010) Study on the selenium nutrition of children in Kaschin–Beck disease endemic areas in Rangtang County, Sichuan Province. Ch J Prev Med 11(7):655–658
Liu Q, Su Q, Xie SH et al (1995) Condition and effect of selenium deficiency in Qinghai Plateau. Guangdong Trace Elem Sci 2(4):56–62
Yan HZ, Gou YF, Su SG et al (1995) Studies on investigation selenium content distribution in blood of crowds in Qinghai-Tibet Plateau. J Environ Health 12(6):214–242
Yao YF, Pei FX, Li XB et al (2012) Preventive effects of supplemental selenium and selenium plus iodine on bone and cartilage development in rats fed with diet from Kaschin–Beck disease endemic area. Biol Trace Elem Res 146(2):199–206
Chen D, Xiong G, Xiao-dong Z et al (2010) Effect of selenium on proliferation and apoptosis of Kaschin–Beck disease chondrocyte cultured in vitro. Chin J Endemiol 29(5):480–484
Moreno-Reyes R, Mathieu F, Boelaert M et al (2003) Selenium and iodine supplementation of rural Tibetan children affected by Kaschin–Beck osteoarthropathy. Am J Clin Nutr 78:137–144
Zhaxi S, Baima C, Xirao R et al (2007) Effect observation on Kaschin–Beck disease control pilots in Tibet Autonomous Region. Chin J Ctrl Endem Dis 22(2):130–131
Baima C, Zhaxi S, Xirao R et al (2007) Effect investigation on supplement selenium of Kaschin–Beck disease in Lingzhou, Xiemengtong Counties, Tibet Autonomous Region. Chin J Endemiol 26(6):710
Gong HQ, Zhaxi S, Xirao R et al (2004) Effect observation on selenium–iodine salt for Kaschin–Beck disease control in Xiemengtong County, Tibet Autonomous Region. Endem Dis Bull 19(1):61–62
Wang YG, Deng JY, Li DY (2005) Dynamic monitoring on Kaschin–Beck disease in Aba County after 22 years. J Prev Medinf 21(1):94–96
Fan XH, Wang XL, Huang Y et al (2012) Prevalence state and analysis on children’s Kaschin-Beck disease in Aba Area, Sichuan Province. Yi Yao Qian Yan 377–378
Li FZ, Deng JY, Huang H et al (2008) Survey of Kaschin–Beck disease activity and related influence factor in Sichuan Province in 2007. Mod Prev Med 35(20):4056–4062
Li Q, Zhao ZHJ, Wen H (2004) Effective observation on children KBD: control with three different methods of selenium supplement in guide endemic area, Qinghai. Endem Dis Bull 19:62–64
Li Q, Zhao ZJ, Zhou LW et al (2010) Effect of changing grain and selenium supplementation on control of children’s Kaschin–Beck disease in Qinghai Province. Chin J Endemiol 29(5):522–524
Hui-zhen Y, Hai-kun W, Zhang Q et al (2010) Level investigation on children after supplement selenium of Kaschin–Beck disease area in Xinghai County, Qinghai Province in 2008. Chin J Endemiol 29(5):492
Zhao ZJ, Li Q (2012) Result analysis on children’s hair selenium supplied of Kaschin–Beck disease area in guide county, Qinghai Province. Chin J Endemiol 31(1):118
Chen JH, Chu YL, Yang ZT et al (2005) Effect of T-2 toxin on chondrocyte apoptosis and Bcl-2, Bex Expression. J Xian Jiaotong Univ (Med Sci) 26(2):130–134
Yang TF, Jia ZQ, Shen B (2001) Effect of T-2 toxin on apoptosis of fetus chondrocyte. Chin J Endemiol 20(2):84–86
Zhang A, Cao JL, Yang B et al (2010) Effects of moniliformin and selenium on human articular cartilage metabolism and their potential relationships to the pathogenesis of Kaschin–Beck disease. J Zhejiang Univ-Sci B (Biomed Biotechnol) 11(3):200–208
Chen JH, Chu YL, Cao JL et al (2011) Effects of T-2 toxin and selenium on chondrocyte expression of matrix metalloproteinases (MMP-1, MMP-13), a2-macroglobulin (a2M) and TIMPs. Toxicol Vitr 25:492–499
Bo-quan Y, Cao JL, Chen JH et al (2012) Effects of T-2 toxin and selenium expression of aggrecanase in human chondrocyte. Chin J Endemiol 31(1):46–50
Chen JH, Chu YL, Yang ZT et al (2006) Protective effect of selenium against T-2 Toxin-induced inhibition of chondrocyte aggrecan and collagen II synthesis. J South Med Univ 26(4):381–385
Li SJ, Yang LS, Wang WY et al (2006) Relationship between selenium concentrations in child hair and the distribution of Kaschin–Beck disease in Tibet, China. Chin J Endemiol 25(1):70–73
Li DY, Deng JY, Zhu L et al (1999) Survey analysis on Kaschin–Beck disease prevalence and hair selenium content of children in endemic areas about 8 years. Chin J Ctrl Endem Dis 14(1):37–38
Deng JY, Li DY, Liang DH et al (1999) The influence on selenium seen from the relationship between Kaschin–Beck disease and selenium in Sichuan Province. Chin J Ctrl Endem Dis 14(4):249–251
Li Q, Wen H, Ding SR et al (2003) Surveillance and analysis of Kaschin–Beck diseases in guide county during 10 years (1992–2001). Chin J Endemiol 22(1):53–54
Li Q, Zhao ZJ (2006) Prevalence state of Kaschin–Beck disease in Qinghai Province: a retrospective analysis. Chin J Endemiol 25(6):675–677
Li QW, Li J, Zhaxi ZD et al (2003) The strategies and measures of Kaschin–Beck disease control in Qing-Tibet Plateau. Chin J Public Health 19(1):1363
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Zhao, ZJ., Li, Q., Yang, Pz. et al. Selenium: A Protective Factor for Kaschin–Beck Disease in Qing-Tibet Plateau. Biol Trace Elem Res 153, 1–4 (2013). https://doi.org/10.1007/s12011-013-9686-8
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DOI: https://doi.org/10.1007/s12011-013-9686-8