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Calcium Fructoborate—Potential Anti-inflammatory Agent

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Abstract

Calcium fructoborate is a boron-based nutritional supplement. Its chemical structure is similar to one of the natural forms of boron such as bis-manitol, bis-sorbitol, bis-fructose, and bis-sucrose borate complexes found in edible plants. In vitro studies revealed that calcium fructoborate is a superoxide ion scavenger and anti-inflammatory agent. It may influence macrophage production of inflammatory mediators, can be beneficial for the suppression of cytokine production, and inhibits progression of endotoxin-associated diseases, as well as the boric acid and other boron sources. The mechanisms by which calcium fructoborate exerts its beneficial anti-inflammatory effects are not entirely clear, but some of its molecular biological in vitro activities are understood: inhibition of the superoxide within the cell; inhibition of the interleukin-1β, interleukin-6, and nitric oxide release in the culture media; and increase of the tumor necrosis factor-α production. Also, calcium fructoborate has no effects on lipopolysaccharide-induced cyclooxygenase-2 protein express. The studies on animals and humans with a dose range of 1–7 mg calcium fructoborate (0.025–0.175 mg elemental boron)/kg body weight/day exhibited a good anti-inflammatory activity, and it also seemed to have negligible adverse effect on humans.

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RS is a Professor in the Biochemistry Department, University of Craiova. RP is a Master of Conferences in the Department of Physics, University of Craiova.

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  1. Department of Biochemistry, University of Craiova, A.I. Cuza Str., Nr. 13, Craiova, Romania

    Romulus Ion Scorei

  2. Department of Physics II, Faculty of Physics, University of Craiova, A.I. Cuza Str., Nr. 13, Craiova, Romania

    Petre Rotaru

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Scorei, R.I., Rotaru, P. Calcium Fructoborate—Potential Anti-inflammatory Agent. Biol Trace Elem Res 143, 1223–1238 (2011). https://doi.org/10.1007/s12011-011-8972-6

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