Abstract
Successful cancer management depends on accurate diagnostics along with specific treatment protocols. Current diagnostic techniques need to be improved to provide earlier detection capabilities, and traditional chemotherapy approaches to cancer treatment are limited by lack of specificity and systemic toxicity. This review highlights advances in nanotechnology that have allowed the development of multifunctional platforms for cancer detection, therapy, and monitoring. Nanomaterials can be used as MRI, optical imaging, and photoacoustic imaging contrast agents. When used as drug carriers, nanoformulations can increase tumor exposure to therapeutic agents and result in improved treatment effects by prolonging circulation times, protecting entrapped drugs from degradation, and enhancing tumor uptake through the enhanced permeability and retention effect as well as receptor-mediated endocytosis. Multiple therapeutic agents such as chemotherapy, antiangiogenic, or gene therapy agents can be simultaneously delivered by nanocarriers to tumor sites to enhance the effectiveness of therapy. Additionally, imaging and therapy agents can be co-delivered to provide seamless integration of diagnostics, therapy, and follow-up, and different therapeutic modalities such as chemotherapy and hyperthermia can be co-administered to take advantage of synergistic effects. Liposomes, metallic nanoparticles, polymeric nanoparticles, dendrimers, carbon nanotubes, and quantum dots are examples of nanoformulations that can be used as multifunctional platforms for cancer theranostics. Nanomedicine approaches in cancer have great potential for clinically translatable advances that can positively impact the overall diagnostic and therapeutic process and result in enhanced quality of life for cancer patients. However, a concerted scientific effort is still necessary to fully explore long-term risks, effects, and precautions for safe human use.
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References
Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010). A Cancer Journal for Clinicians, 60, 267–300.
Wang, X., Wang, Y., Chen, Z. G., & Shin, D. M. (2009). Cancer Research Treatment, 41, 1–11.
Ehlrich, P. (1906). Collected studies on immunity (pp. 404–443). New York: Wiley.
Kreuter, J. (1996). Journal of Anatomy, 189(Pt 3), 503–505.
Breimer, D. D. (1998). Advanced Drug Delivery Reviews, 33, 265–268.
Brandl, M. (2001). Biotechnology Annual Review, 7, 59–85.
de Estella-Hermoso, M. A., Campanero, M. A., Mollinedo, F., & Blanco-Prieto, M. J. (2009). Journal of Biomedical Nanotechnology, 5, 323–343.
Matsumura, Y., Hamaguchi, T., Ura, T., et al. (2004). British Journal of Cancer, 91, 1775–1781.
Lee, J. H., Jung, S. W., Kim, I. S., et al. (2003). International Journal of Pharmaceutics, 251, 23–32.
Liu, Z. H., Jiao, Y. P., Wang, Y. F., et al. (2008). Advanced Drug Delivery Reviews, 60, 1650–1662.
Xu, Z. P., Zeng, Q. H., Lu, G. Q., & Yu, A. B. (2006). Chemical Engineering Science, 61, 1027–1040.
Dakhil, S., Ensminger, W., Cho, K., et al. (1982). Cancer, 50, 631–635.
Nelken, N., & Schneider, P. A. (2004). Surgical Clinics of North America, 84, 1203–1236.
Gregoriadis, G., Leathwood, P. D., & Ryman, B. E. (1971). FEBS Letters, 14, 95–99.
Gregoriadis, G., & Ryman, B. E. (1972). European Journal of Biochemistry, 24, 485–491.
Banerjee, R. (2001). Journal of Biomaterials Applications, 16, 3–21.
Axelsson, B. (1989). Advanced Drug Delivery Reviews, 3, 391–404.
Bakker-Woudenberg, I., Lokerse, A., ten Kate, M., et al. (1993). European Journal of Clinical Microbiology, 12, S61–S67.
Lestini, B. J., Sagnella, S. M., Xu, Z., et al. (2002). Journal of Controlled Release, 78, 235–247.
Tarahovsky, Y. S. (2010). Biochemistry (Mosc), 75, 811–824.
Strother, R., & Matei, D. (2009). Therapeutic Clinical Risk Management, 5, 639–650.
Fassas, A., & Anagnostopoulos, A. (2005). Leukemia & Lymphoma, 46, 795–802.
Sapra, P., Tyagi, P., & Allen, T. M. (2005). Current Drug Delivery, 2, 369–381.
Sarris, A. H., Hagemeister, F., Romaguera, J., et al. (2000). Annals of Oncology, 11, 69–72.
Chhikara, B. S., & Parang, K. (2010). Expert Opinion on Drug Delivery, 7, 1399–1414.
Cattel, L., Ceruti, M., & Dosio, F. (2003). Tumori, 89, 237–249.
Salzberg, M., Thurlimann, B., Bonnefois, H., et al. (2005). Oncology, 68, 293–298.
Cheung, T. W., Remick, S. C., Azarnia, N., et al. (1999). Clinical Cancer Research, 5, 3432–3437.
Koukourakis, M. I., Koukouraki, S., Giatromanolaki, A., et al. (1999). Journal of Clinical Oncology, 17, 3512–3521.
Caponigro, F., Comella, P., Budillon, A., et al. (2000). Annals of Oncology, 11, 339–342.
Roerdink, F., Dijkstra, J., Hartman, G., et al. (1981). BBA General Subjects, 677, 79–89.
Blume, G., Cevc, G., Crommelin, M. D. J. A., et al. (1993). BBA Review Biomembranes, 1149, 180–184.
Mori, A., Klibanov, A. L., Torchilin, V. P., & Huang, L. (1991). FEBS Letters, 284, 263–266.
Allen, T. M. (1994). Advanced Drug Delivery Reviews, 13, 285–309.
Burger, J. J., Tomlinson, E., Mulder, E. M. A., & McVie, J. G. (1985). International Journal of Pharmaceutics, 23, 333–344.
Anderson, J. M., & Shive, M. S. (1997). Advanced Drug Delivery Reviews, 28, 5–24.
Birrenbach, G. S. P. (1976). Journal of Pharmaceutical Sciences, 65, 1763.
Avgoustakis, K. (2004). Current Drug Delivery, 1, 321–333.
Fahmy, T. M., Fong, P. M., Goyal, A., & Saltzman, W. M. (2005). Materials Today, 8, 18–26.
Chung, Y. I., Kim, J. C., Kim, Y. H., et al. (2010). Journal of Controlled Release, 143, 374–382.
Nicolas, J., & Couvreur, P. (2009). Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 1, 111–127.
Kumari, A., Yadav, S. K., & Yadav, S. C. (2009). Colloid Surface B, 75, 1–18.
Nagpal, K., Singh, S. K., & Mishra, D. N. (2010). Chemical and Pharmaceutical Bulletin (Tokyo), 58, 1423–1430.
Jayakumar, R., Prabaharan, M., Nair, S. V., & Tamura, H. (2010). Biotechnology Advances, 28, 142–150.
Dash, M., Chiellini, F., Ottenbrite, R., & Chiellini, E. (2011). Progress in Polymer Science, 36, 981–1014.
Corsi, K., Chellat, F., Yahia, L., & Fernandes, J. C. (2003). Biomaterials, 24, 1255–1264.
Erbacher, P., Zou, S., Bettinger, T., et al. (1998). Pharmaceutical Research, 15, 1332–1339.
Kumar, M., Behera, A. K., Lockey, R. F., et al. (2002). Human Gene Therapy, 13, 1415–1425.
Kievit, F. M., Veiseh, O., Bhattarai, N., et al. (2009). Advanced Functional Materials, 19, 2244–2251.
Tripathi, S. K., Goyal, R., Kumar, P., & Gupta, K. C. (2011). Nanomedicine. doi:10.1016/j.nano.2011.06.022.
Aktas, Y., Andrieux, K., Alonso, M. J., et al. (2005). International Journal of Pharmaceutics, 298, 378–383.
Karatas, H., Aktas, Y., Gursoy-Ozdemir, Y., et al. (2009). Journal of Neuroscience, 29, 13761–13769.
Son, Y. J., Jang, J. S., Cho, Y. W., et al. (2003). Journal of Controlled Release, 91, 135–145.
Mitra, S., Gaur, U., Ghosh, P. C., & Maitra, A. N. (2001). Journal of Controlled Release, 74, 317–323.
Janes, K. A., Fresneau, M. P., Marazuela, A., et al. (2001). Journal of Controlled Release, 73, 255–267.
Lee, E., Lee, J., Lee, I. H., et al. (2008). Journal of Medicinal Chemistry, 51, 6442–6449.
Min, K. H., Park, K., Kim, Y. S., et al. (2008). Journal of Controlled Release, 127, 208–218.
Hwang, H. Y., Kim, I. S., Kwon, I. C., & Kim, Y. H. (2008). Journal of Controlled Release, 128, 23–31.
Ohya, Y., Takei, T., Kobayashi, H., & Ouchi, T. (1993). Journal of Microencapsulation, 10, 1–9.
Wang, X., Li, Y., & Du, Y. (2009). Journal of Nanoscience and Nanotechnology, 9, 6866–6875.
Cheong, S. J., Lee, C. M., Kim, S. L., et al. (2009). International Journal of Pharmaceutics, 372, 169–176.
Nam, T., Park, S., Lee, S. Y., et al. (2010). Bioconjugate Chemistry, 21, 578–582.
Baldrick, P. (2010). Regulatory Toxicology and Pharmacology, 56, 290–299.
Acharya, S., & Sahoo, S. K. (2011). Advanced Drug Delivery Reviews, 63, 170–183.
Yoo, H. S., Lee, K. H., Oh, J. E., & Park, T. G. (2000). Journal of Controlled Release, 68, 419–431.
Park, J., Fong, P. M., Lu, J., et al. (2009). Nanomedicine, 5, 410–418.
Bhardwaj, V., Ankola, D. D., Gupta, S. C., et al. (2009). Pharmaceutical Research, 26, 2495–2503.
Gradishar, W. J., Tjuladin, S., Davidson, N., Shaw, H., Desai, N., Bhar, P., et al. (2005). J Clin Oncol, 23, 7794–7803.
Reynolds, C., Barrera, D., Jotte, R., et al. (2009). Journal of Thoracic Oncology, 4, 1537–1543.
Nyman, D. W., Campbell, K. J., Hersh, E., et al. (2005). Journal of Clinical Oncology, 23, 7785–7793.
Tang, Y., Lei, T., Manchanda, R., et al. (2010). Pharmaceutical Research, 27, 2242–2253.
Song, X. R., Cai, Z., Zheng, Y., et al. (2009). European Journal of Pharmaceutical Sciences, 37, 300–305.
Agueros, M., Areses, P., Campanero, M. A., et al. (2009). European Journal of Pharmaceutical Sciences, 37, 231–240.
Balthasar, S., Michaelis, K., Dinauer, N., et al. (2005). Biomaterials, 26, 2723–2732.
Cheng, F. Y., Su, C. H., Wu, P. C., & Yeh, C. S. (2010). Chemical Communications (Cambridge, England), 46, 3167–3169.
Cho, H. S., Dong, Z., Pauletti, G. M., et al. (2010). ACS Nano, 4, 5398–5404.
Dai, H., Jiang, X., Tan, G. C., et al. (2006). International Journal of Nanomedecine, 1, 507–522.
Danhier, F., Vroman, B., Lecouturier, N., et al. (2009). Journal of Controlled Release, 140, 166–173.
Derakhshandeh, K., Soheili, M., Dadashzadeh, S., & Saghiri, R. (2010). International Journal of Nanomedecine, 5, 463–471.
ElBayoumi, T. A., & Torchilin, V. P. (2009). Clinical Cancer Research, 15, 1973–1980.
Huh, M. S., Lee, S. Y., Park, S., et al. (2010). Journal of Controlled Release, 144, 134–143.
Jain, A. K., Swarnakar, N. K., Godugu, C., et al. (2011). Biomaterials, 32, 503–515.
Jiang, X., Dai, H., Leong, K. W., et al. (2006). The Journal of Gene Medicine, 8, 477–487.
Kim, K., Kim, J. H., Park, H., et al. (2010). Journal of Controlled Release, 146, 219–227.
Kocbek, P., Obermajer, N., Cegnar, M., et al. (2007). Journal of Controlled Release, 120, 18–26.
Lee, S. M., Park, H., & Yoo, K. H. (2010). Advanced Materials, 22, 4049–4053.
Liu, Y., Li, K., Liu, B., & Feng, S. S. (2010). Biomaterials, 31, 9145–9155.
Misra, R., & Sahoo, S. K. (2010). European Journal of Pharmaceutical Sciences, 39, 152–163.
Musumeci, T., Ventura, C. A., Giannone, I., et al. (2006). International Journal of Pharmaceutics, 325, 172–179.
Pille, J. Y., Li, H., Blot, E., et al. (2006). Human Gene Therapy, 17, 1019–1026.
Qu, J., Liu, G., Wang, Y., & Hong, R. (2010). Advanced Powder Technology, 21, 461–467.
Sahana, B., Santra, K., Basu, S., & Mukherjee, B. (2010). International Journal of Nanomedicine, 5, 621–630.
Saxena, V., Sadoqi, M., & Shao, J. (2006). International Journal of Pharmaceutics, 308, 200–204.
Wang, H., Zhao, P., Su, W., et al. (2010). Biomaterials, 31, 8741–8748.
Wang, J., Tao, X., Zhang, Y., et al. (2010). Biomaterials, 31, 4426–4433.
Wu, P., He, X., Wang, K., et al. (2009). Journal of Biomedical Nanotechnology, 5, 557–564.
Yallapu, M. M., Gupta, B. K., Jaggi, M., & Chauhan, S. C. (2010). Journal of Colloid and Interface Science, 351, 19–29.
Maeda, H., Wu, J., Sawa, T., et al. (2000). Journal of Controlled Release, 65, 271–284.
Maeda, H., Bharate, G. Y., & Daruwalla, J. (2009). European Journal of Pharmaceutics and Biopharmaceutics, 71, 409–419.
Hall, J. B., Dobrovolskaia, M. A., Patri, A. K., & McNeil, S. E. (2007). Nanomedicine, 2, 789–803.
Seymour, L. W., Miyamoto, Y., Maeda, H., et al. (1995). European Journal of Cancer, 31, 766–770.
Tolcher, A. W., Sugarman, S., Gelmon, K. A., et al. (1999). Journal of Clinical Oncology, 17, 478–484.
Brennan, F. R., Shaw, L., Wing, M. G., & Robinson, C. (2004). Molecular Biotechnology, 27, 59–74.
Chang, H. R. (2010). Cancer, 116, 2856–2867.
Glass, B., Ziepert, M., Reiser, M., et al. (2010). Annals of Oncology, 21, 2255–2261.
Yoon, D. H., Choi, D. R., Ahn, H. J., et al. (2010). European Journal of Haematology, 85, 149–157.
Frampton, J. E., & Keating, G. M. (2008). BioDrugs, 22, 113–120.
Kanwar, J. R., Mahidhara, G., & Kanwar, R. K. (2011). Drug Discovery Today, 16, 188–202.
Lee, J. F., Hesselberth, J. R., Meyers, L. A., & Ellington, A. D. (2004). Nucleic Acids Research, 32(D95), 100.
Ruckman, J., Green, L., Beeson, J., et al. (1998). Journal of Biological Chemistry, 273, 20556–20567.
Kourlas, H., & Schiller, D. S. (2006). Clinical Therapeutics, 28, 36–44.
Farokhzad, O. C., Cheng, J. J., Teply, B. A., et al. (2006). Proceedings of the National Academy of Sciences of the United States of America, 103, 6315–6320.
Toffoli, G., Cernigoi, C., Russo, A., et al. (1997). International Journal of Cancer, 74, 193–198.
Parker, N., Turk, M. J., Westrick, E., et al. (2005). Analytical Biochemistry, 338, 284–293.
Park, J. W., Hong, K. L., Kirpotin, D. B., et al. (2002). Clinical Cancer Research, 8, 1172–1181.
Lei, T., Srinivasan, S., Tang, Y., et al. (2011). Nanomedicine and Nanotechnology, 7, 324–332.
Agrawal, V., Paul, M. K., & Mukhopadhyay, A. K. (2005). Journal of Liposome Research, 15, 141–155.
Song, X. R., Zheng, Y., He, G., et al. (2010). Journal of Pharmaceutical Sciences, 99, 4874–4879.
Soma, C. E., Dubernet, C., Bentolila, D., et al. (2000). Biomaterials, 21, 1–7.
Fan, L., Li, F., Zhang, H. T., et al. (2010). Biomaterials, 31, 5634–5642.
Tardi, P., Johnstone, S., Harasyrn, N., et al. (2009). Leukemia Research, 33, 129–139.
Harasym, T. O., Tardi, P. G., Harasym, N. L., et al. (2007). Oncology Research, 16, 361–374.
Guo, J., Zhou, J., Ying, X., et al. (2010). Journal of Pharmacy and Pharmacology Science, 13, 136–151.
Jiang, J. A., Yang, S. J., Wang, J. C., et al. (2010). European Journal of Pharmaceutics and Biopharmaceutics, 76, 170–178.
Zhang, L., Radovic-Moreno, A. F., Alexis, F., et al. (2007). ChemMedChem, 2, 1268–1271.
Fayette, M., Soria, J. C., & Armand, J. P. (2005). European Journal of Cancer, 41, 1109–1116.
Emanuel, S., Gruninger, R. H., Fuentes-Pesquera, A., et al. (2004). Molecular Pharmaceutics, 66, 635–647.
Ma, J., & Waxman, D. J. (2008). Molecular Cancer Therapeutics, 7, 3670–3684.
Couzin, J. (2002). Science, 296, 2314–2315.
Sengupta, S., Eavarone, D., Capila, I., et al. (2005). Nature, 436, 568–572.
Liu, F., Shollenberger, L. M., & Huang, L. (2004). The FASEB Journal, 18, 1779–1781.
Wang, Y., Gao, S. J., Ye, W. H., et al. (2006). Nature Materials, 5, 791–796.
Devi, G. R. (2006). Cancer Gene Therapy, 13, 819–829.
Zhu, C., Jung, S., Luo, S., et al. (2010). Biomaterials, 31, 2408–2416.
Chen, Y. C., Bathula, S. R., Li, J., & Huang, L. (2010). Journal of Biological Chemistry, 285, 22639–22650.
Chen, Y. C., Wu, J. Z. J., & Huang, L. (2010). Molecular Therapy, 18, 828–834.
Saad, M., Garbuzenko, O. B., & Minko, T. (2008). Nanomedicine, 3, 761–776.
Sun, T. M., Du, J. Z., Yao, Y. D., et al. (2011). Acs Nano , 5(2), 1483–1494.
Minelli, C., Lowe, S. B., & Stevens, M. M. (2010). Small, 6, 2336–2357.
Grubisha, D. S., Lipert, R. J., Park, H. Y., et al. (2003). Analytical Chemistry, 75, 5936–5943.
Gerion, D., Chen, F., Kannan, B., et al. (2003). Analytical Chemistry, 75, 4766–4772.
Xia, Z., Xing, Y., So, M. K., et al. (2008). Analytical Chemistry, 80, 8649–8655.
Asami, Y., Oishi, J., Kitazaki, H., et al. (2011). Anal Biochem, 418, 44–49.
Hill, H. D., & Mirkin, C. A. (2006). Nature Protocols, 1, 324–336.
Stoeva, S. I., Lee, J. S., Smith, J. E., et al. (2006). Journal of the American Chemical Society, 128, 8378–8379.
Simpson, C. R., Kohl, M., Essenpreis, M., & Cope, M. (1998). Physics in Medicine and Biology, 43, 2465–2478.
Weissleder, R., Tung, C. H., Mahmood, U., & Bogdanov, A. (1999). Nature Biotechnology, 17, 375–378.
Lee, H. Y., Li, Z., Chen, K., et al. (2008). Journal of Nuclear Medicine, 49, 1371–1379.
Kang, K. W. (2010). Open Nuclear Medicine Journal, 2, 153–156.
Yang, J., Lee, C. H., Ko, H. J., et al. (2007). Angewandte Chemie (International Ed. in English), 46, 8836–8839.
Park, K., Lee, S., Kang, E., et al. (2009). Advances Functional Materials, 19, 1553–1566.
Huang, X., Jain, P. K., El-Sayed, I. H., & El-Sayed, M. A. (2008). Lasers in Medical Science, 23, 217–228.
Huff, T. B., Hansen, M. N., Zhao, Y., et al. (2007). Langmuir, 23, 1596–1599.
Oyelere, A. K., Chen, P. C., Huang, X. H., et al. (2007). Bioconjugate Chemistry, 18, 1490–1497.
von Maltzahn, G., Centrone, A., Park, J. H., et al. (2009). Advanced Materials, 21, 3175–3180.
Li, C. Z., Male, K. B., Hrapovic, S., & Luong, J. H. (2005). Chemical Communications (Cambridge), 3924–3926.
Ann-Ann D., Ying-Yi C., Wang C.C., et al. (2008). HER-2 antibody conjugated gold nano rod for in vivo photothermal therapy. In 8th IEEE conference on Nanotechnology NANO’08, 882–885.
Park, H., Yang, J., Lee, J., et al. (2009). ACS Nano, 3, 2919–2926.
Wust, P., Gneveckow, U., Johannsen, M., et al. (2006). International Journal of Hyperthermia, 22, 673–685.
Day, E. S., Morton, J. G., & West, J. L. (2009). Journal of Biomechanical Engineering, 131, 074001.
Dorshow, R. B., Bugaj, J. E., & Burleigh, B. D. (1998). Journal of Biomedical Optics, 3, 340–345.
Johansen, P. L. (1990). European Heart Journal, 11(Suppl I), 6–12.
O’Neal, D. P., Hirsch, L. R., Halas, N. J., et al. (2004). Cancer Letters, 209, 171–176.
Hirsch, L. R., Stafford, R. J., Bankson, J. A., et al. (2003). Proceedings of the National Academy of Sciences of the United States of America, 100, 13549–13554.
Fernandez-Fernandez, A., Manchanda, R., Lei, T., et al. (2011). Comparative study of the optical and heat generation properties of IR820 and indocyanine green. Molecular Imaging, [Epub ahead of print].
Manchanda, R., Fernandez-Fernandez, A., Nagesetti, A., & McGoron, A. J. (2010). Colloid Surface B, 75, 260–267.
Wang, Y., Li, X., Zhou, Y., et al. (2010). International Journal of Pharmaceutics, 384, 148–153.
Gao, Z., Kennedy, A. M., Christensen, D. A., & Rapoport, N. Y. (2008). Ultrasonics, 48, 260–270.
Rapoport, N., Nam, K. H., Gupta, R., et al. (2011). Journal of Controlled Release, 153, 4–15.
Rapoport, N., Kennedy, A. M., Shea, J. E., et al. (2010). Molecular Pharmaceutics, 7, 22–31.
Watanabe, Y., Horie, S., Funaki, Y., et al. (2010). Journal of Nuclear Medicine, 51, 951–958.
Xu, J. S., Huang, J., Qin, R., et al. (2010). Biomaterials, 31, 1716–1722.
Paparel, P., Curiel, L., Chesnais, S., et al. (2005). BJU International, 95, 881–885.
Prat, F., Chapelon, J. Y., el Fadil, F. A., et al. (1993). British Journal of Cancer, 68, 13–17.
Sinha, N., & Yeow, J. T. (2005). IEEE Transactions on Nanobioscience, 4, 180–195.
De La Zerda, A., Zavaleta, C., Keren, S., et al. (2008). Nature Nanotechnology, 3, 557–562.
Panchapakesan, B., Cesarone, G., Teker, K., & Wickstrom, E. (2006). NanoBiotechnology, 1, 353–360.
Liu, Z., Chen, K., Davis, C., et al. (2008). Cancer Research, 68, 6652–6660.
Panchapakesan, B., Lu, S., Sivakumar, K., et al. (2005). NanoBiotechnology, 1, 133–140.
Poland, C. A., Duffin, R., Kinloch, I., et al. (2008). Nature Nanotechnology, 3, 423–428.
Shvedova, A. A., Kisin, E. R., Porter, D., et al. (2009). Pharmacology and Therapeutics, 121, 192–204.
Park, E. J., Roh, J., Kim, S. N., et al. (2011). Archives of Toxicology, 85, 1121–1131.
Tomalia, D. A., Baker, H., Dewald, J., et al. (1986). Macromolecules, 19, 2466–2468.
Menjoge, A. R., Kannan, R. M., & Tomalia, D. A. (2010). Drug Discovery Today, 15, 171–185.
Zhu, S. J., Hong, M. H., Tang, G. T., et al. (2009). Biomaterials, 31, 1360–1371.
Gerretsen, S. C., Versluis, B., Bekkers, S. C. A. M., & Leiner, T. (2008). European Journal of Radiology, 65, 80–85.
Tekade, R. K., Dutta, T., Gajbhiye, V., & Jain, N. K. (2009). Journal of Microencapsulation, 26, 287–296.
Lee, C. C., Gillies, E. R., Fox, M. E., et al. (2006). Proceedings of the National Academy of Sciences of the United States of America, 103, 16649–16654.
Kobayashi, H., & Brechbiel, M. W. (2003). Molecular Imaging, 2, 1–10.
Quintana, A., Raczka, E., Piehler, L., et al. (2002). Pharmaceutical Research, 19, 1310–1316.
Kaneshiro, T. L., & Lu, Z. R. (2009). Biomaterials, 30, 5660–5666.
Thomas, T. P., Shukla, R., Kotlyar, A., et al. (2010). Bioorganic & Medicinal Chemistry Letters, 20, 700–703.
Rupp, R., Rosenthal, S. L., & Stanberry, L. R. (2007). International Journal of Nanomedicine, 2, 561–566.
Voura, E. B., Jaiswal, J. K., Mattoussi, H., & Simon, S. M. (2004). Nature Medicine, 10, 993–998.
Chan, W. C., & Nie, S. (1998). Science, 281, 2016–2018.
Guo, W., Li, J. J., Wang, Y. A., & Peng, X. (2003). Journal of the American Chemical Society, 125, 3901–3909.
Pinaud, F., King, D., Moore, H. P., & Weiss, S. (2004). Journal of the American Chemical Society, 126, 6115–6123.
Park, J. H., von Maltzahn, G., Ruoslahti, E., et al. (2008). Angewandte Chemie (International Ed. in English), 47, 7284–7288.
Gao, X., Cui, Y., Levenson, R. M., et al. (2004). Nature Biotechnology, 22, 969–976.
Derfus, A. M., Chan, W. C. W., & Bhatia, S. N. (2004). Nano Letters, 4, 11–18.
Hondroulis, E., Liu, C., & Li, C. Z. (2010). Nanotechnology, 21, 315103.
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A.F.F. received support from NIH/NIGMS R25 GM061347.
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Fernandez-Fernandez, A., Manchanda, R. & McGoron, A.J. Theranostic Applications of Nanomaterials in Cancer: Drug Delivery, Image-Guided Therapy, and Multifunctional Platforms. Appl Biochem Biotechnol 165, 1628–1651 (2011). https://doi.org/10.1007/s12010-011-9383-z
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DOI: https://doi.org/10.1007/s12010-011-9383-z