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Sleep Abnormalities in Wilson’s Disease

  • Sleep Disorders (A Iranzo, Section Editor)
  • Published:
Current Treatment Options in Neurology Aims and scope Submit manuscript

Abstract

Purpose of review

The aim of this article was to review the different sleep disorders associated with Wilson’s disease (WD), their mechanisms and their treatments.

Recent findings

Some of these disorders such as REM sleep behavior disorder or sleepiness can appear as a prodromal phase phenomenon in WD allowing an early treatment of the disease and sometimes a resolution of the sleep disorder.

Summary

Sleep disorders in WD are frequent combining insomnia, daytime sleepiness, restless legs syndrome (RLS), cataplexy-like episodes, and REM sleep behavior disorder (RBD). Sleep recordings confirm these disorders. Mechanisms involved in these disorders are complex associating (a) lesions of the pathways regulating sleep and wake or mood but also controlling movement, (b) iatrogenic effects of the treatments, and (3) consequences of the motor or dysautonomic or metabolic disorders.

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Author information

Authors and Affiliations

  1. Sleep Unit, Beau Soleil Clinic, 119 Avenue de Lodève, 34070, Montpellier, France

    Valérie Cochen De Cock MD, PhD

  2. EuroMov, Montpellier University, 700 Avenue du Pic Saint Loup, 34090, Montpellier, France

    Valérie Cochen De Cock MD, PhD

  3. French National Reference Centre for Wilson’s Disease, University Hospital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France

    Nadège Girardot-Tinant PhD, France Woimant MD & Aurélia Poujois MD, PhD

  4. Department of Neurology, University Hospital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France

    Nadège Girardot-Tinant PhD, France Woimant MD & Aurélia Poujois MD, PhD

Authors
  1. Valérie Cochen De Cock MD, PhD
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  2. Nadège Girardot-Tinant PhD
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  3. France Woimant MD
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  4. Aurélia Poujois MD, PhD
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Corresponding author

Correspondence to Valérie Cochen De Cock MD, PhD.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Sleep Disorders

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Cochen De Cock, V., Girardot-Tinant, N., Woimant, F. et al. Sleep Abnormalities in Wilson’s Disease. Curr Treat Options Neurol 20, 46 (2018). https://doi.org/10.1007/s11940-018-0531-4

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  • DOI: https://doi.org/10.1007/s11940-018-0531-4

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