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Serum FABP1 Levels Correlate Positively with Obesity in Chinese Patients After Laparoscopic Sleeve Gastrectomy: a 12-Month Follow-up Study

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Abstract

Objective

The role of liver fatty acid-binding protein (FABP1) in obesity is presently unclear. We investigated the association of FABP1 with obesity and the changes noted after laparoscopic sleeve gastrectomy (LSG) in a Chinese population.

Methods

The cross-sectional analysis included 187 individuals: 65 had normal weight (18.5 ≤ body mass index (BMI) < 24 kg/m2), 59 were overweight (24 ≤ BMI < 28 kg/m2), and 63 were obese (BMI ≥ 28 kg/m2). We also assessed 25 severely obese patients (BMI, 38.58 ± 4.59 kg/m2) at baseline and at 3, 6, and 12 months after LSG to observe FABP1 levels.

Results

FABP1 levels in the obese (30.33 ± 23.59 ng/ml, **P < 0.01, ***P < 0.001) and overweight (18.96 ± 18.75 ng/ml, P = 0.471) individuals were significantly higher than those in normal weight individuals (14.30 ± 9.37 ng/ml). Linear regression analysis revealed that the FABP1 levels were positively correlated with BMI (R2 = 0.201, ***P < 0.001), ALT (R2 = 0.324, ***P < 0.001), AST (R2 = 0.387, ***P < 0.001), m-AST (R2 = 0.160, ***P < 0.001), γ-GT (R2 = 0.106, ***P < 0.001), DBil (R2 = 0.078, ***P < 0.001), UA (R2 = 0.111, ***P < 0.001), FBG (R2 = 0.066, ***P < 0.001), LDL (R2 = 0.042, **P = 0.005), and were negatively correlated with HDL (R2 = 0.051, **P = 0.002). After adjusting for age, sex, ALT, AST, TC, TG, HDL, LDL, FBG, and UA, FABP1 was independently correlated with BMI (*P < 0.05). With decreasing BMI after LSG, the FABP1 levels (29.46 ± 21.19 ng/ml, P = 0.463, P = 0.06, *P < 0.05) also decreased at 3 (23.00 ± 22.77 ng/ml), 6 (14.41 ± 15.48 ng/ml), and 12 months (11.55 ± 3.27 ng/ml).

Conclusion

Serum FABP1 levels are closely correlated with obesity and many metabolic factors, and we found that with the decrease in BMI after LSG, the FABP1 levels also progressively decreased postoperatively.

Trial Registration

ClinicalTrials.gov Identifier: ChiCTR-OCS-12002381

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Funding

This study is supported by the National Key R&D Program of China (No.2018YFC1314100). This research was also supported by the National Natural Science Foundation of China (NSFC 81700752, 81500687, 81601269, 81970677).

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, No. 301 Middle Yanchang Road, Shanghai, 200072, China

    Hui You, Xin Wen, Cuiling Zhu, Liu Yang, Le Bu, Manna Zhang, Donglei Zhou, Liesheng Lu, Lei Du, Ziwei Lin & Shen Qu

  2. National Metabolic Management Center, Shanghai, 200072, China

    Hui You, Xin Wen, Cuiling Zhu, Liu Yang, Le Bu, Manna Zhang, Donglei Zhou, Liesheng Lu, Lei Du, Ziwei Lin & Shen Qu

  3. Thyroid Disease Research Center of Shanghai, Shanghai, 200072, China

    Hui You, Xin Wen, Cuiling Zhu, Liu Yang, Le Bu, Manna Zhang, Ziwei Lin & Shen Qu

  4. Physical examination center of Shanghai Tenth People’s Hospital, Shanghai, China

    Ming Chen, Liting Dong & Yanli Zhu

  5. Department of Gastrointestinal Surgery, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, China

    Donglei Zhou, Liesheng Lu & Lei Du

Authors
  1. Hui You
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  2. Xin Wen
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  3. Cuiling Zhu
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  4. Ming Chen
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  7. Liu Yang
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  8. Le Bu
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  9. Manna Zhang
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  11. Liesheng Lu
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  12. Lei Du
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  13. Ziwei Lin
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  14. Shen Qu
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Corresponding authors

Correspondence to Ziwei Lin or Shen Qu.

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Informed consent was obtained from all participants included in the study.

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The study was approved by the ethics committee of Shanghai Tenth People’s Hospital.

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You, H., Wen, X., Zhu, C. et al. Serum FABP1 Levels Correlate Positively with Obesity in Chinese Patients After Laparoscopic Sleeve Gastrectomy: a 12-Month Follow-up Study. OBES SURG 30, 931–940 (2020). https://doi.org/10.1007/s11695-019-04307-3

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