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Prediction of Diabetes Remission at Long Term Following Biliopancreatic Diversion

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Abstract

Importance

In obese patients with type 2 diabetes (T2DM), the marked weight loss following bariatric surgery is accompanied in a consistent number of cases by T2DM resolution or control. The clinical need of preoperative parameters reliable in predicting a positive metabolic outcome at long term following the operation has then emerged.

Observation

A cohort of 135 consecutive T2DM patients with a wide range of body mass index (BMI) at more than 5 years following biliopancreatic diversion (BPD) was considered. The 5-year-T2DM resolution, defined as glycosylated hemoglobin (HbA1C) lower than 6.5% without antidiabetic therapy, was related to demographic, anthropometric, and biochemical findings prior to the operation. The long-term metabolic outcome was positively related to baseline BMI values and negatively with the preoperative use of insulin.

Conclusion

BMI and insulin therapy at the time of surgery are associated with the probability of T2DM long lasting remission and could be used as solid predictors before surgery. In the overweight and non morbidly obese diabetic patients, bariatric surgery is less efficient in determining long term T2DM resolution than in their morbid obese counterparts.

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Authors and Affiliations

  1. Department of Surgery, IRCCS San Martino and Università di Genova, Genoa, Italy

    Nicola Scopinaro

  2. Department of Endocrinology, IRCCS San Martino and Università di Genova, Genoa, Italy

    Gian Franco Adami & Renzo Cordera

  3. Department of Internal Medicine, University of Genova, Viale Benedetto XV, 8, 15132, Genoa, Italy

    Gian Franco Adami & Renzo Cordera

  4. Department of Statistics, IRCCS San Martino and Università di Genova, Genoa, Italy

    Paolo Bruzzi

Authors
  1. Nicola Scopinaro
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  2. Gian Franco Adami
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  3. Paolo Bruzzi
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  4. Renzo Cordera
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Corresponding author

Correspondence to Gian Franco Adami.

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In this type of study, ethical approval is not necessary.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Scopinaro, N., Adami, G.F., Bruzzi, P. et al. Prediction of Diabetes Remission at Long Term Following Biliopancreatic Diversion. OBES SURG 27, 1705–1708 (2017). https://doi.org/10.1007/s11695-017-2555-3

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  • DOI: https://doi.org/10.1007/s11695-017-2555-3

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