Skip to main content
Log in

The liver tissue bank and clinical database in China

  • Research Article
  • Published:
Frontiers of Medicine in China Aims and scope Submit manuscript

Abstract

To develop a standardized and well-rounded material available for hepatology research, the National Liver Tissue Bank (NLTB) Project began in 2008 in China to make well-characterized and optimally preserved liver tumor tissue and clinical database. From Dec 2008 to Jun 2010, over 3000 individuals have been enrolled as liver tumor donors to the NLTB, including 2317 cases of newly diagnosed hepatocellular carcinoma (HCC) and about 1000 cases of diagnosed benign or malignant liver tumors. The clinical database and sample store can be managed easily and correctly with the data management platform used. We believe that the high-quality samples with detailed information database will become the cornerstone of hepatology research especially in studies exploring the diagnosis and new treatments for HCC and other liver diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Franceschi S, Raza S A. Epidemiology and prevention of hepatocellular carcinoma. Cancer Lett, 2009, 286(1): 5–8

    Article  CAS  PubMed  Google Scholar 

  2. Caldwell S, Park S H. The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology. J Gastroenterol, 2009, 44(Suppl 19): 96–101

    Article  PubMed  Google Scholar 

  3. Fu S Y, Lai E C, Li A J, Pan Z Y, Yang Y, Sun Y M, Lau W Y, Wu M C, Zhou W P. Liver resection with selective hepatic vascular exclusion: a cohort study. Ann Surg, 2009, 249(4): 624–627

    Article  PubMed  Google Scholar 

  4. Pan Z Y, Yang Y, Zhou W P, Li A J, Fu S Y, Wu M C. Clinical application of hepatic venous occlusion for hepatectomy. Chin Med J (Engl), 2008, 121(9): 806–810

    Google Scholar 

  5. Mager S R, Oomen M H, Morente M M, Ratcliffe C, Knox K, Kerr D J, Pezzella F, Riegman P H. Standard operating procedure for the collection of fresh frozen tissue samples. Eur J Cancer, 2007, 43(5): 828–834

    Article  CAS  PubMed  Google Scholar 

  6. Patel A A, Gilbertson J R, Parwani A V, Dhir R, Datta M W, Gupta R, Berman J J, Melamed J, Kajdacsy-Balla A, Orenstein J, Becich M J; Cooperative Prostate Cancer Tissue Resource. An informatics model for tissue banks-lessons learned from the Cooperative Prostate Cancer Tissue Resource. BMC Cancer, 2006, 6: 120

    Article  PubMed  Google Scholar 

  7. Fowler S B, Sohler P, Zarillo D F. Bar-code technology for medication administration: medication errors and nurse satisfaction. Medsurg Nurs, 2009, 18(2): 103–109

    PubMed  Google Scholar 

  8. Jewell S D, Srinivasan M, McCart L M, Williams N, Grizzle W H, LiVolsi V, MacLennan G, Sedmak D D. Analysis of the molecular quality of human tissues: an experience from the Cooperative Human Tissue Network. Am J Clin Pathol, 2002, 118(5): 733–741

    Article  CAS  PubMed  Google Scholar 

  9. van Veen E B, Riegman P H, Dinjens W N, Lam K H, Oomen M H, Spatz A, Mager R, Ratcliffe C, Knox K, Kerr D, van Damme B, van de Vijver M, van Boven H, Morente M M, Alonso S, Kerjaschki D, Pammer J, Lopez-Guerrero J A, Llombart Bosch A, Carbone A, Gloghini A, Teodorovic I, Isabelle M, Passioukov A, Lejeune S, Therasse P, Oosterhuis J W. TuBaFrost 3: regulatory and ethical issues on the exchange of residual tissue for research across Europe. Eur J Cancer, 2006, 42(17): 2914–2923

    Article  PubMed  Google Scholar 

  10. Riegman P H, Oomen M H, Dinjens W N, Oosterhuis J W, Lam K H, Spatz A, Ratcliffe C, Knox K, Mager R, Kerr D, Pezzella F, Van Damme B, Van De Vijver M, Van Boven H, Morente M M, Alonso S, Kerjaschki D, Pammer J, López-Guerrero J A, Llombart-Bosch A, Carbone A, Gloghini A, Teodorovic I, Isabelle M, Passioukov A, Lejeune S, Therasse P, Van Veen E B. TuBaFrost: European virtual tumor tissue banking. Adv Exp Med Biol, 2006, 587: 65–74

    Article  CAS  PubMed  Google Scholar 

  11. Riegman P H, Dinjens W N, Oomen M H, Spatz A, Ratcliffe C, Knox K, Mager R, Kerr D, Pezzella F, van Damme B, van de Vijver M, van Boven H, Morente MM, Alonso S, Kerjaschki D, Pammer J, Lopez-Guerrero J A, Llombart Bosch A, Carbone A, Gloghini A, Teodorovic I, Isabelle M, Jaminé D, Passioukov A, Lejeune S, Therasse P, van Veen E B, Lam K H, Oosterhuis J W. TuBaFrost 1: Uniting local frozen tumour banks into a European network: an overview. Eur J Cancer, 2006, 42(16): 2678–2683

    Article  CAS  PubMed  Google Scholar 

  12. Popescu I, Stroescu C, Dumitrascu T, Herlea V, Paslaru L, Lazar V, Boissin H, Taieb J, Horeanga I. Digestive tumor bank protocol: from surgical specimens to genomic studies of digestive cancers. Chirurgia (Bucur), 2006, 101(5): 471–475

    CAS  Google Scholar 

  13. Morente M M, Mager R, Alonso S, Pezzella F, Spatz A, Knox K, Kerr D, Dinjens W N, Oosterhuis J W, Lam K H, Oomen M H, van Damme B, van de Vijver M, van Boven H, Kerjaschki D, Pammer J, Lopez-Guerrero J A, Llombart Bosch A, Carbone A, Gloghini A, Teodorovic I, Isabelle M, Passioukov A, Lejeune S, Therasse P, van Veen E B, Ratcliffe C, Riegman P H. TuBaFrost 2: Standardising tissue collection and quality control procedures for a European virtual frozen tissue bank network. Eur J Cancer, 2006, 42(16): 2684–2691

    Article  CAS  PubMed  Google Scholar 

  14. Lopez-Guerrero J A, Riegman P H, Oosterhuis J W, Lam K H, Oomen M H, Spatz A, Ratcliffe C, Knox K, Mager R, Kerr D, Pezzella F, van Damme B, van de Vijver M, van Boven H, Morente M M, Alonso S, Kerjaschki D, Pammer J, Carbone A, Gloghini A, Teodorovic I, Isabelle M, Passioukov A, Lejeune S, Therasse P, van Veen E B, Dinjens W N, Llombart-Bosch A. TuBaFrost 4: access rules and incentives for a European tumour bank. Eur J Cancer, 2006, 42(17): 2924–2929

    Article  CAS  PubMed  Google Scholar 

  15. Isabelle M, Teodorovic I, Morente M M, Jaminé D, Passioukov A, Lejeune S, Therasse P, Dinjens W N, Oosterhuis J W, Lam K H, Oomen M H, Spatz A, Ratcliffe C, Knox K, Mager R, Kerr D, Pezzella F, van de Vijver M, van Boven H, Alonso S, Kerjaschki D, Pammer J, Lopez-Guerrero J A, Llombart Bosch A, Carbone A, Gloghini A, van Veen E B, van Damme B, Riegman P H. TuBaFrost 5: multifunctional central database application for a European tumor bank. Eur J Cancer, 2006, 42(18): 3103–3109

    Article  CAS  PubMed  Google Scholar 

  16. Møller S, Jensen MB, Ejlertsen B, Bjerre K D, Larsen M, Hansen H B, Christiansen P, Mouridsen H T; Danish Breast Cancer Cooperative Group. The clinical database and the treatment guidelines of the Danish Breast Cancer Cooperative Group (DBCG); its 30-years experience and future promise. Acta Oncol, 2008, 47(4): 506–524

    Article  PubMed  Google Scholar 

  17. Bauchet L, Rigau V, Mathieu-Daudé H, Figarella-Branger D, Hugues D, Palusseau L, Bauchet F, Fabbro M, Campello C, Capelle L, Durand A, Trétarre B, Frappaz D, Henin D, Menei P, Honnorat J, Segnarbieux F. French brain tumor data bank: methodology and first results on 10,000 cases. J Neurooncol, 2007, 84(2): 189–199

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Wei-Ping Zhou or Hong-Yang Wang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, Y., Liu, YM., Wei, MY. et al. The liver tissue bank and clinical database in China. Front. Med. China 4, 443–447 (2010). https://doi.org/10.1007/s11684-010-0190-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11684-010-0190-7

Keywords

Navigation