Zusammenfassung
Hintergrund
Trotz der zunehmenden Bedeutung gesundheitsökonomischer Analysen für die psychiatrische Versorgungsforschung sind insbesondere neuere methodische Ansätze in diesem Bereich in Deutschland bisher nur wenig bekannt.
Methode
Es werden innovative methodische Ansätze der gesundheitsökonomischen Evaluation dargestellt und deren Anwendungsmöglichkeiten im Bereich der psychiatrischen Versorgungsforschung beispielhaft demonstriert.
Ergebnisse
Behandelt werden die Interpretation von Kosteneffektivitätsrelationen mit Hilfe der Kosteneffektivitätsfläche, die Varianzschätzung für inkrementelle Kosteneffektivitätsrelationen mit der Bootstrapping-Methode und die Interpretation der Kosteneffektivitätsakzeptanzkurve. Als Alternative zur inkrementellen Kosteneffektivitätsanalyse wird der Nettonutzenansatz vorgestellt.
Schlussfolgerungen
Mit dem Nettonutzenansatz werden die Anwendungsmöglichkeiten gesundheitsökonomischer Analysen in der psychiatrischen Versorgungsforschung bedeutend erweitert.
Abstract
Background
Despite the growing importance of health economic analysis in mental health services research recent methodological developments in this field are widely disregarded in Germany.
Methods
Innovative approaches of cost-effectiveness analysis will be presented and its application in mental health service research will be demonstrated.
Results
The interpretation of cost-effectiveness ratios on the background of the cost-effectiveness plane, the problem of variance estimation for the ICER, the application of bootstrapping methods for the assessment of confidence limits and the interpretation of the cost-effectiveness acceptability curve will be demonstrated. As an alternative method to the use of incremental cost-effectiveness ratios the net benefit approach will be presented.
Conclusions
The advantageous characteristics of the net benefit approach increase the applicability of health economic analysis in mental health service research.
Literatur
Briggs A, Fenn P (1998) Confidence intervals or surfaces? Uncertainty on the cost-effectiveness plane. Health Econ 7: 723–740
Briggs AH, O’Brien B (2001) The death of cost-minimization analysis? Health Econ 10: 179–184
Briggs A (1999) Economics notes: handling uncertainty in economic evaluation. Br Med J 319: 120
Chisholm D (2003) Cost-effective strategies for reducing the global burden of mentall ill-helth: a generalised approach. Mental Health Res Rev 9: 27–29
Chisholm D (2005) Choosing cost-effective interventions in psychiatry: results from the CHOICE programme of the World Health Organization. World Psychiatry 4: 37–44
Chisholm D (2005) Keeping pace with assessing cost-effectiveness: economic efficiency and priority-setting in mental health. Aust N Z J Psychiatry 39: 645–647
Chisholm D, Healey A, Knapp M (1997) QALYs and mental health care. Soc Psychiatry Psychiatr Epidemiol 32: 68–75
Chisholm D, van OM, yuso-Mateos JL, Saxena S (2005) Cost-effectiveness of clinical interventions for reducing the global burden of bipolar disorder. Br J Psychiatry 187: 559–567
D’Agostino RB (1998) Tutorial in biostatistics. Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med 17: 2265–2281
Dolan P (2001) Utilitarianism and the measurement and aggregation of quality – adjusted life years. Health Care Anal 9: 65–76
Garber AM, Weinstein MC, Torrance GW, Kamlet MS (2005) Theoretical foundations of cost-effectiveness analysis. In: Gold MR, Siegel JE, Russel LB, Weinstein MC (eds) Cost-effectiveness in health and medicine. Oxford University Press, New York Oxford, pp 25–53
Gold MR, Patrick DL, Torrance GW et al. (1996) Identifying and valuing outcomes. In: Gold MR, Siegel JE, Russel LB, Weinstein MC (eds) Cost-effectiveness in health and medicine. Oxford University Press, New York Oxford
Gold MR, Siegel JE, Russel LB, Weinstein MC (1996) Cost-effectiveness in health and medicine. New York Oxford: Oxford University Press
Hargreaves WA, Shumway M, Hu TW, Cuffel B (1998) Cost-outcome methods for mental health. Academic Press, San Diego London New York
Healey A, Chisholm D (1999) Willingness to pay as a measure of the benefits of mental health care. J Ment Health Policy Econ 2: 55–58
Hoch JS, Briggs AH, Willan R (2002) Something old, something new, something borrowed, something blue: a framework for the marriage of health econometrics and cost-effectiveness analysis. Health Econ 11: 415–430
Hoch JS, Rockx MA, Krahn AD (2006) Using the net benefit regression framework to construct cost-effectiveness acceptability curves: an example using data from a trial of external loop recorders versus Holter monitoring for ambulatory monitoring of „community acquired“ syncope. BMC Health Serv Res 6: 68
Hoch JS, Smith MW (2006) A guide to economic evaluation: methods for cost-effectiveness analysis of person-level data. J Trauma Stress 19: 787–797
Kilian R (2007) Die Anwendung der Kosteneffektivitätsanalyse in der psychiatrischen Versorgungsforschung. Methodische Probleme und Lösungsansätze (The application of cost-effectiveness analysis in mental health services research. Methodological prolbems and solutions. Psychiat Prax 34(1): 138–139
Kilian R, Angermeyer MC (2005) The effects of antipsychotic treatment on quality of life of schizophrenic patients under naturalistic treatment conditions: An application of random effect regression models and propensity scores in an observational prospective trial. Qual Life Res 14: 1275–1289
Kilian R, Becker T (2006) Aktuelle Entwicklungstendenzen psychiatrischer Versorgungsforschung. In: Pawils S, Koch U (Hrsg) Psychosoziale Versorgung in der Medizin. Schattauer, Stuttgart, S 331–342
Kilian R, Becker T (2007) Versorgungsforschung und medizinischer Fortschritt. Etablierung einer Brückendisziplin in der Psychiatrie. Neurotransmitter 18: 37–38
Kilian R, Knenelly B, McDaid D, Becker T (2007) Gesundheitsökonomische Aspekte der Suizidprävention. Health economic aspects of suicide prevention. Suizidprophylaxe 34: 220–236
Kilian R, Roick C, Angermeyer MC (2004) Methodische Probleme und Lösungsansätze der Kostenerfassung und der Kostenanalyse in der psychiatrischen Versorgung am Beispiel der Schizophreniebehandlung. In: Vogel H, Wasem J (Hrsg) Gesundheitsökonomie in Psychotherapie und Psychiatrie. Gesundheitsökonomische Untersuchungen in der psychotherapeutischen und psychiatrischen Versorgung. Schattauer, Stuttgart New York, S 76–99
Kilian R, Angermeyer MC (2004) The impact of antipsychotic medication on the incidence and the costs of inpatient treatment in people with schizophrenia: results from a prospective observational study. Psychiatr Prax 31: 138–146
Kilian R, Angermeyer MC (2005) The effects of antipsychotic treatment on quality of life of schizophrenic patients under naturalistic treatment conditions: an application of random effect regression models and propensity scores in an observational prospective trial. Qual Life Res 14: 1275–1289
Kilian R, Angermeyer MC, Becker T (2004) Methodolocical issues of naturalistic observational studies on the economic evaluation of neuroleptic treatment for schizophrenic disease. Gesundheitswesen 66: 180–185
Kilian R, Dietrich S, Toumi M, Angermeyer MC (2004) Quality of life in persons with schizophrenia in out-patient treatment with first- or second-generation antipsychotics. Acta Psychiatr Scand 110: 108–118
Kilian R, Roick C, Angermeyer MC (2003) The impact of the study design and the sampling procedure on the assessment of mental health services. Nervenarzt 74: 561–570
Laha RG (1958) An example of a nonnormal distribution where the quotient follows the cauchy law. Proc Natl Acad Sci USA 44: 222–223
Lopez AD, Mathers CD, Ezzati M et al. (2006) Global and regional burden of disease and risk factors 2001: systematic analysis of population health data. Lancet 367: 1747–1757
March JS, Silva SG, Compton S et al. (2005) The case for practical clinical trials in psychiatry. Am J Psychiatr 162: 836–846
Mason J, Drummond M, Torrance G (1993) Some guidelines on the use of cost effectiveness league tables. Br Med J 306: 570–572
Mont D (2007) Measuring health and disability. Lancet 369: 1658–1663
Muening P (2002) Desinging and conducting cost-effectiveness analyses in medicine and health care. Jossey-Bass, San Francisco
Mulvaney-Day NE (2005) Using willingness to pay to measure family members‘ preferences in mental health. J Ment Health Policy Econ 8: 71–81
Polsky D, Glick HA, Willke R, Schulman K (1997) Confidence intervals for cost-effectiveness ratios: A comparison of four methods. Health Econ 6: 243–252
Reidpath DD, Allotey PA, Kouame A, Cummins RA (2003) Measuring health in a vacuum: examining the disability weight of the DALY. Health Policy Plan 18: 351–356
Revicki DA (1995) Measuring health outcomes for cost-effectiveness studies: are all quality adjusted life years created equal? Drug Inf J 29: 1459–1467
Russel LB, Siegel JE, Daniels N et al. (1996) Cost-effectiveness analysis as a guide to resource allocation in health: roles and limitations. In: Gold MR, Siegel JE, Russel LB, Weinstein MC (eds) Cost-effectiveness in health and medicine. Oxford University Press, New York Oxford, pp 3–24
Schöffski O, Glaser P, Graf von der Schulenburg M (1998) Gesundheitsökonomische Evaluationen. Grundlagen und Standortbestimmungen. Springer, Berlin Heidelberg New York
Schrappe M, Glaeske G, Gottwik M et al. (2005) Konzeptionelle, methodische und strukturelle Voraussetzungen der Versorgungsforschung. Dtsch Med Wochenschr 130: 2918–2922
Sendi PP, Briggs AH (2001) Affordability and cost-effectiveness: Decision making on the cost-effectiveness plane. Health Econ 10: 675–680
Stant AD, Buskens E, Jenner JA et al. (2007) Cost-effectiveness analysis in severe mental illness: outcome measures selection. J Ment Health Policy Econ 10: 101–108
Ustun TB, Chisholm D (2001) Global „burden of disease“-study for psychiatric disorders. Psychiatr Prax 28(Suppl 1): 7–11
Viscusi WK (2003) The value of life: Estimates with risks by occupation and industry. Disussion Paper No 422 Cambridge: HAVARD John M Olin Center for Law, Economics and Business, Cambridge
Willan AR, Briggs AH, Hoch JS (2004) Regression methods for covariate adjustment and subgroup analysis for non-censored cost-effectiveness data. Health Econ 13: 461–475
World Health Organization (2001) Atlas Mental health resources in the world 2001. World Health Organization, Geneva
Interessenkonflikt
Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kilian, R. Gesundheitsökonomische Evaluation in der psychiatrischen Versorgungsforschung. Präv Gesundheitsf 3, 135–144 (2008). https://doi.org/10.1007/s11553-008-0120-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11553-008-0120-6