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Diabetesrisikoscores

Ein Update 2014

Diabetes risk scores

Update 2014

  • Leitthema
  • Published:
Der Diabetologe Aims and scope

Zusammenfassung

Hintergrund

In den letzten 15 Jahren ist die Entwicklung von Diabetesrisikoscores immer stärker Gegenstand der epidemiologischen Forschung geworden.

Ziel der Arbeit

In der vorliegenden Arbeit werden zeitliche Trends und die weltweite Verteilung der entwickelten Vorhersagemodelle dargestellt sowie nichtinvasive extern validierte Diabetesrisikoscores beschrieben.

Material und Methoden

Auf der Basis eines im Jahr 2011 publizierten Reviews und einer Online-Datenbank mit jährlichem Update zu Veröffentlichungen mit Diabetesrisikoscores werden Informationen zu der Entwicklung und Validierung dieser Scores gesammelt und zusammengefasst dargestellt.

Ergebnisse

Bis Ende 2013 wurden insgesamt 392 einzelne Diabetesprädiktionsmodelle publiziert. Von diesen sind 23 Modelle (5,9 %) nichtinvasiv, d. h., sie sind ohne Einbezug von biochemischen oder genetischen Parametern und damit für ein breites Spektrum an Einsatzmöglichkeiten in der Bevölkerung geeignet, sowie extern validiert worden. Die Mehrheit wurde in Europa entwickelt. So liegt für Deutschland mit dem DIfE – DEUTSCHER-DIABETES-RISIKO-TEST® (DRT) ein mehrfach validiertes Prädiktionsmodell vor.

Diskussion

Es gibt eine wachsende Anzahl an validierten Risikoscores, die für die Vorhersage eines Diabetesrisikos nutzbar sind. Ihre Eignung für die Praxis hängt davon ab, ob sie in der Zielpopulation validiert wurden und Erhebungs- und Berechnungsmöglichkeiten, z. B. in Form von Fragebögen, zur Verfügung stehen.

Abstract

Background

During the past 15 years the development of diabetes risk scores has increasingly become the subject of epidemiologic research.

Objectives

Trends over time and the worldwide distribution of prediction models that have been developed are presented and non-invasive, externally validated diabetes risk scores are described.

Materials and methods

Based on the review published in 2011 and an annually updated online database on published research of diabetes risk scores, information regarding the development and validation of the scores were collected and summarized.

Results

Overall, 392 single diabetes risk scores were calculated through the end of 2013. Out of these, 23 were non-invasive (i.e., without biochemical or genetic parameters and thereby appropriate for use in various settings in the population) and were validated in an external population. The majority was developed in Europe. With the DIfE – DEUTSCHER-DIABETES-RISIKO-TEST® (DRT), a multiply validated prediction model also exists for Germany.

Discussion

There is a growing number of validated diabetes risk scores which are useful for the prediction of the diabetes risk. Their adequacy for application in clinical practice depends, on the one hand, on whether these were validated in the target population and, on the other hand, on the availability of tools for assessment or calculation (e.g., in the form of questionnaires).

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Einhaltung ethischer Richtlinien

Interessenkonflikt. K. Mühlenbruch und M. B. Schulze geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Abteilung Molekulare Epidemiologie, Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114–116, 14558, Nuthetal, Deutschland

    K. Mühlenbruch &  M.B. Schulze

  2. Deutsches Zentrum für Diabetesforschung (DZD), Neuherberg, Deutschland

    K. Mühlenbruch &  M.B. Schulze

Authors
  1. K. Mühlenbruch
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  2. M.B. Schulze
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Correspondence to K. Mühlenbruch.

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Mühlenbruch, K., Schulze, M. Diabetesrisikoscores. Diabetologe 10, 554–565 (2014). https://doi.org/10.1007/s11428-014-1209-5

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  • DOI: https://doi.org/10.1007/s11428-014-1209-5

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