Abstract
The purpose of this study was to develop regression-based prediction equations for estimating dual-energy X-ray absorptiometry (DXA)-derived appendicular lean soft tissue mass (aLM) using ultrasound and to investigate the validity of these equations in 102 Caucasian adults aged 50 to 76 years. The subjects were randomly separated into two groups: 71 in the model-development group (41 men and 30 women) and 31 in the cross-validation group (18 men and 13 women). aLM was measured using a DXA, and muscle thickness (MT) was measured using ultrasound at 9 sites. Stepwise linear regression analysis was used to determine predictive models for DXA-derived aLM from MT variables, sex, and age. A number of ultrasound prediction equations for estimation of aLM were developed and then cross-validated in a subsample of older adults. The results indicated that ultrasound MT and MT × height can be used to accurately and reliably estimate DXA-derived aLM in older Caucasian adults.
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References
Abe T, Kondo M, Kawakami Y, Fukunaga T (1994) Prediction equations for body composition of Japanese adults by B-mode ultrasound. Am J Hum Biol 6:161–170
Abe T, Kearns CF, Fukunaga T (2003) Sex differences in whole body skeletal muscle mass measured by magnetic resonance imaging and its distribution in young Japanese adults. Br J Sports Med 37:436–440
Abe T, Mitsukawa N, Thiebaud RS, Loenneke JP, Loftin M, Ogawa M (2012) Lower body site-specific sarcopenia and accelerometer-determined moderate and vigorous physical activity: the HIREGASAKI study. Aging Clin Exp Res 24:657–662
Abe T, Loenneke JP, Thiebaud RS, Fukunaga T (2014a) Age-related site-specific muscle wasting of upper and lower extremities and trunk in Japanese men and women. AGE (Dordr) 36:813–821
Abe T, Loenneke JP, Thiebaud RS, Loftin M (2014b) Morphological and functional relationships with ultrasound measured muscle thickness of the upper extremity and trunk. Ultrasound 22:229–235
Abe T, Counts BR, Barnett BE, Dankel SJ, Lee K, Loenneke JP (2015a) Associations between handgrip strength and ultrasound-measured muscle thickness of the hand and forearm in young men and women. Ultrasound Med Biol 41:2125–2130
Abe T, Loenneke JP, Young KC, Thiebaud RS, Nahar VK, Hollaway KM, Stover CD, Ford MA, Bass MA, Loftin M (2015b) Validity of ultrasound prediction equations for total and regional muscularity in middle-aged and older men and women. Ultrasound Med Biol 41:557–564
Abe T, Patterson KM, Stover CD, Young KC (2015c) Influence of adipose tissue mass on DXA-derived lean soft tissue mass in middle-aged and older women. AGE (Duedr) 37:2
Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross R, Garry PJ, Linderman RD (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147:755–763
Bunout D, de la Maza MP, Barrera G, Leiva L, Hirsch S (2011) Association between sarcopenia and mortality in healthy older people. Australas J Ageing 30:89–92
Burns JM, Johnson DK, Watts A, Swerdlow RH, Brooks WM (2010) Reduced lean mass in elderly Alzheimer disease and its association with brain atrophy. Arch Neurol 67:428–433
Dupler TL, Tolson H (2000) Body composition prediction equations for elderly men. J Gerontol A Biol Sci Med Sci 55:M180–M184
Gallagher D, Visser M, De Meersman RE, Sepulveda D, Baumgartner RN, Pierson RN, Harris T, Heymsfield SB (1997) Appendicular skeletal muscle mass: effect of age, gender, and ethnicity. J Appl Physiol 83:229–239
Heymsfield SB, Gallagher D, Kotler DP, Wang Z, Allison DB, Heshka S (2002) Body-size dependence of resting energy expenditure can be attributed to nonenergetic homogeneity of fat-free mass. Am J Physiol Endocrinol Metab 282:E132–E138
Janssen I, Heymsfield SB, Wang ZM, Ross R (2000) Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr. J Appl Physiol 89:81–88
Kim J, Wang Z, Heymsfield SB, Baumgartner RN, Gallagher D (2002) Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method. Am J Clin Nutr 76:378–383
Kyle UG, Genton L, Hans D, Karsegard L, Slosman DO, Pichard C (2001) Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years. Eur J Clin Nutr 55:663–672
Kulkarni B, Kuper H, Taylor A, Wells JC, Radhakrishna KV, Kinra S, Ben-Shlomo Y, Smith GD, Ebrahim S, Byrne NM, Hills AP (2013) Development and validation of anthropometric prediction equations for estimation of lean body mass and appendicular lean soft tissue in Indian men and women. J Appl Physiol 115:1156–1162
Lin LI (1989) A concordance correlation coefficient to evaluate reproducibility. Biometrics 45:255–268
Oguri K, Zhao L, Du N, Kato Y, Miyamoto M, Kurokawa J, Nagasaki S, Matsuoka T (2004) Association of habitual long-distance running with the thickness of skeletal muscles and subcutaneous fat in the body extremities and trunk in middle-aged men. J Sports Med Phys Fitness 44:417–423
Ozaki H, Loenneke JP, Thiebaud RS, Abe T (2015) Cycle training induces muscle hypertrophy and strength gain: strategies and mechanisms. Acta Physiol Hung 102:1–22
Park SW, Goodpaster BH, Lee JS, Kuller LH, Boudreau R, de Rekeneire N, Harris TB, Kritchevsky S, Tylavsky FA, Nevitt M, Cho YW, Newman AB, Health, Aging, and Body Composition Study (2009) Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care 32:1993–1997
Sanada K, Kearns CF, Midorikawa T, Abe T (2006) Prediction and validation of total and regional skeletal muscle mass by ultrasound in Japanese adults. Eur J Appl Physiol 96:24–31
Sergi G, De Rui M, Veronese N, Bolzetta F, Berton L, Carraro S, Bano G, Manzato E, Perissinotto E (2015) Assessing appendicular skeletal muscle mass with bioelectrical impedance analysis in free-living Caucasian older adults. Clin Nutr 34:667–673
Shih R, Wang Z, Heo M, Wang W, Heymsfield SB (2000) Lower limb skeletal muscle mass: development of dual-energy X-ray absorptiometry prediction model. J Appl Physiol 89:1380–1386
Takai Y, Ohta M, Akagi R, Kato E, Wakahara T, Kawakami Y, Fukunaga T, Kanehisa H (2013) Validity of ultrasound muscle thickness measurements for predicting leg skeletal muscle mass in healthy Japanese middle-aged and older individuals. J Physiol Anthropol 32:12
Takai Y, Ohta M, Akagi R, Kato E, Wakahara T, Kawakami Y, Fukunaga T, Kanehisa H (2014) Applicability of ultrasound muscle thickness measurements for predicting fat-free mass in elderly population. J Nutr Health Aging 18:579–585
Tanimoto Y, Watanabe M, Sun W, Sugiura Y, Tsuda Y, Kimura M, Hayashida I, Kusabiraki T, Kono K (2012) Association between sarcopenia and high-level functional capacity in daily living in community-dwelling elderly patients in Japan. Arch Gerontol Geriatr 55:e9–e13
Vetrano DL, Landi F, Volpato S, Corsonello A, Meloni E, Bernabei R, Onder G (2014) Association of sarcopenia with short- and long-term mortality in older adults admitted to acute care words results from the CRIME study. J Gerontol A Biol Sci Med Sci 69:1154–1161
Acknowledgments
The authors thank the individuals who participated in this study. We also thank Dr. Paul D. Loprinzi in the Department of HESRM, The University of Mississippi, for his helpful statistical analysis comments.
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Abe, T., Thiebaud, R.S., Loenneke, J.P. et al. Prediction and validation of DXA-derived appendicular lean soft tissue mass by ultrasound in older adults. AGE 37, 114 (2015). https://doi.org/10.1007/s11357-015-9853-2
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DOI: https://doi.org/10.1007/s11357-015-9853-2