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Obstructive sleep apnea and the risk of mortality in patients with lung cancer: a meta-analysis

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

Prior reports have examined the relationship between obstructive sleep apnea (OSA) and the mortality rate of lung cancer. However, the findings remain controversial. The present meta-analysis was performed to assess the relationship between OSA and increased risk of mortality in patients with lung cancer.

Methods

PubMed, Web of Science, and Embase were systematically searched for the correlative studies. Data were analyzed and pooled to evaluate odds ratios (ORs) of lung cancer mortality related to OSA.

Results

From 249 identified studies, 3 met inclusion criteria and were analyzed, including 67 patients with lung cancer and comorbid OSA and 45 patients with lung cancer and no OSA. The meta-analysis indicated that OSA was not significantly correlated with mortality rate in lung cancer (OR = 2.005, 95% CI = 0.703 to 5.715, z = 1.30, p = 0.193). There was no significant publication bias according to Begg’s tests (p = 0.296) and Egger’s tests (p = 0.097).

Conclusion

This meta-analysis suggests that OSA is not significantly correlated with the mortality rate in lung cancer.

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Data availability

All data generated or analyzed during this study are included in this published article.

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Funding

This work was supported by grant from Science and Technology Major Project of Fujian Province (2017YZ0001-2) and National Natural Science Foundation of China (81900088, 81870074). The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

Author information

Author notes

  1. Meng-Xue Chen, Li-Da Chen, and Ai-Ming Zeng contributed equally to this work

Authors and Affiliations

  1. Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Fujian Medical University, No 20, Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian Province, People’s Republic of China

    Meng-Xue Chen, Ai-Ming Zeng, Jian-Chai Huang, Jie-Feng Huang & Qi-Chang Lin

  2. Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People’s Republic of China

    Li-Da Chen

  3. Department of Laboratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People’s Republic of China

    Xue-Jun Lin

  4. Department of Respiratory and Critical Care Medicine, 900Th Hospital of the Joint Logistics Support Force, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, Fuzhou, People’s Republic of China

    Guo-Xiang Lai

  5. Fujian Provincial Sleep-Disordered Breathing Clinic Center, Fuzhou, Fujian Province, People’s Republic of China

    Qi-Chang Lin

  6. Laboratory of Respiratory Disease of the Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of China

    Qi-Chang Lin

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  1. Meng-Xue Chen
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Correspondence to Qi-Chang Lin.

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All analyses were based on previous published studies; thus, no ethical approval and patient consent are required.

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Chen, MX., Chen, LD., Zeng, AM. et al. Obstructive sleep apnea and the risk of mortality in patients with lung cancer: a meta-analysis. Sleep Breath 26, 559–566 (2022). https://doi.org/10.1007/s11325-021-02416-x

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  • DOI: https://doi.org/10.1007/s11325-021-02416-x

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