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Mechanisms of the Analgesic Action of Corticotrophin-Releasing Factor on Somatic Pain Sensitivity in Rats

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This review provides an analysis of data on the mechanisms of the analgesic action of corticotropin-releasing factor (CRF) on somatic pain sensitivity. Experiments on rats addressed the involvement of opioid and glucocorticoid receptors and type 2 CRF receptors in mediating the analgesic effect induced by systemic administration of CRF. The results showed that the analgesic action of CRF may involve type 2 CRF receptors; CRF analgesia can appear in two forms: opioid-dependent and opioid-independent, whose development appears to be determined by the nature of the pain stimulus and the use of anesthesia. The opioid-dependent form of analgesia may be supported by glucocorticoid hormones.

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  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    N. I. Yarushkina, T. R. Bagaeva & L. P. Filaretova

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  1. N. I. Yarushkina
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  2. T. R. Bagaeva
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  3. L. P. Filaretova
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Correspondence to N. I. Yarushkina.

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 99, No. 7, pp. 805–819, July, 2013.

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Yarushkina, N.I., Bagaeva, T.R. & Filaretova, L.P. Mechanisms of the Analgesic Action of Corticotrophin-Releasing Factor on Somatic Pain Sensitivity in Rats. Neurosci Behav Physi 45, 449–457 (2015). https://doi.org/10.1007/s11055-015-0095-7

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  • DOI: https://doi.org/10.1007/s11055-015-0095-7

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