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Correlation between serum CA724 and gastric cancer: multiple analyses based on Chinese population

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Abstract

Serum tumor biomarker carbohydrate antigen 724 (CA724) is noticeable for gastric cancer. Correlation between CA724 and gastric cancer was investigated based on Chinese population. Chinese Biomedical Database, Chinese Journal Full-text Database and PubMed were searched. Gastric cancer patients were proven by biopsy, and control included health volunteers or benign gastric diseases. Participants received at least one test of CA724, CA125, CA153, CA199, CA242 or CEA. Meta-analysis, summary ROC (SROC) and post hoc analysis were performed by RevMan 5.0 and SPSS 11.5. Totally, 33 eligible studies were analyzed. Meta-analysis showed CA724 had the highest odds ratio 32.86 compared to control, orderly followed by CA242, CA199, CEA, CA125 and CA153. Accumulated accuracy rate of CA724 was 77 %, superior to others. In SROC analysis, specificity of all studies was above 0.70, but sensitivity of few studies was above 0.70; CA724 was selected as the preferable single test, followed by CA242, CA199, CEA, CA125 and CA153. If threshold of both specificity and sensitivity up to 0.70, CA153 was unacceptable; if up to 0.80, only CA724 and CA242 were considerable. In CA724-combined patterns, CA724+CEA+CA199 combination performed best by increasing sensitivity to 0.74 without impairing specificity, while CA724 + CA199 pattern was not a proper combination. CA724 was the most correlative serum tumor biomarker for gastric cancer in Chinese population. Sensitivity of serum CA724 is limited, but CA724+CEA+CA199 combination is considerable to improve sensitivity without impairing specificity.

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Acknowledgments

The authors thank the substantial work by Mr. Zhang WK from the Gastrointestinal Volunteer Team (GIVOLT) based on the Multidisciplinary Treatment Project of Gastrointestinal Tumors, West China Hospital, Sichuan University, China. Domestic support from (1) National Natural Science Foundation of China (no. 81071777), and (2) Outstanding Young Scientific Scholarship Foundation of Sichuan University, from the Fundamental Research Funds for the Central Universities of China (no. 2011SCU04B19).

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Guo Xue Xiang, No. 37, Chengdu, 610041, Sichuan, China

    Xin-Zu Chen, Kun Yang, Jian-Kun Hu, Bo Zhang, Zhi-Xin Chen, Jia-Ping Chen & Zong-Guang Zhou

  2. Faculty of Medical Technology, West China Medical School, Sichuan University, Chengdu, China

    Wei-Ke Zhang

  3. Laboratory of Clinical Immunology, West China Hospital, Sichuan University, Chengdu, China

    Lan-Lan Wang & Jin Liu

  4. Chinese Cochrane Center, West China Hospital, Sichuan University, Chengdu, China

    Li Wang

  5. Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

    Xian-Ming Mo

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  1. Xin-Zu Chen
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Chen, XZ., Zhang, WK., Yang, K. et al. Correlation between serum CA724 and gastric cancer: multiple analyses based on Chinese population. Mol Biol Rep 39, 9031–9039 (2012). https://doi.org/10.1007/s11033-012-1774-x

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