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Modulation of sialic acid levels among some organs during insulin resistance or hyperglycemic states

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Abstract

Previous studies have suggested a possible connection between insulin resistance and chronic hyperglycemia with membrane sialic acid content. In this study, the effects of high (20 % ad libitum) fructose and glucose feeding on the sialic acid levels of some organs were investigated in rats. The blood glucose levels of the high fructose- and glucose-fed rats were consistently and significantly (P < 0.05) higher than the normal control throughout the experiment. Free serum sialic acid and total hepatic sialic acid levels were elevated in the high fructose- and glucose-fed rats compared to normal control, but only the data for the high glucose-fed group were significantly (P < 0.05) different from the normal control. Conversely, a significant (P < 0.05) decrease in the pancreatic sialic acid level was observed in high glucose-fed group compared to normal control. Also, the high fructose-fed rats had lower, but insignificant (P > 0.05), pancreatic sialic acid level than the normal control. On the other hand, high fructose and glucose feeding did not significantly (P > 0.05) affect the sialic acid levels of the skeletal muscle and heart, though a tendency to increase the sialic acid level was evident in the heart. In the kidney, the sialic acid level was significantly (P < 0.05) increased in both high fructose- and glucose-fed groups. It was concluded that the liver and kidney tend to stimulate sialic acid synthesis, while the pancreas downregulate sialic acids synthesis and/or promote sialic acid release from glycoconjugates. Also, these organs may contribute to high-serum sialic acid level observed during diabetes.

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References

  1. Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE (2014) Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract 103:137–149. doi:10.1016/j.diabres.2013.11.002

    Article  CAS  PubMed  Google Scholar 

  2. Salas-Salvado J, Martinez-Gonzalez MA, Bullo M, Ros E (2011) The role of diet in the prevention of type 2 diabetes. Nutr Metab Cardiovasc Dis 21(Suppl 2):B32–B48. doi:10.1016/j.numecd.2011.03.009

    Article  CAS  PubMed  Google Scholar 

  3. American Diabetes Association (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33(Suppl 1):S62–S69. doi:10.2337/dc10-S062

    Article  PubMed Central  Google Scholar 

  4. Nayak BS, Duncan H, Lalloo S, Maraj K, Matmungal V, Matthews F, Prajapati B, Samuel R, Sylvester P (2008) Correlation of microalbumin and sialic acid with anthropometric variables in type 2 diabetic patients with and without nephropathy. Vasc Health Risk Manag 4(1):243–247

    Article  CAS  Google Scholar 

  5. Prajna K, Ashok KJ, Srinidhi R, Shobith KS, Tirthal R, Mohamedi B, Shashikala MD (2013) Predictive value of serum sialic acid in type-2 diabetes mellitus and its complication (nephropathy). J Clin Diagn Res 7(11):2435–2437. doi:10.7860/JCDR/2013/6210.3567

    CAS  Google Scholar 

  6. Rahman I, Malik AS, Bashir M, Khan R, Iqbal M (2009) Serum sialic acid changes in non-insulin-dependent diabetes mellitus (NIDDM) patients following bitter melon (Momordica charantia) and rosiglitazone (Avandia) treatment. Phytomedicine 16:401–405. doi:10.1016/j.phymed.2009.01.001

    Article  Google Scholar 

  7. Englyst NA, Crook MA, Lumb P, Stears AJ, Masding MG, Wootton SA, Sandeman DD, Bryne CD (2006) Percentage of body fat and plasma glucose predict plasma sialic acid concentration in type 2 diabetes mellitus. Metabolism 55:1165–1170

    Article  CAS  PubMed  Google Scholar 

  8. Khalili P, Sundstrom J, Jendle J, Lundin F, Jungner I, Nilsson PM (2014) Sialic acid and incidence of hospitalization for diabetes and its complications during 40-years of follow- up in a large cohort: the Värmland survey. Prim Care Diabetes 8(4):352–357. doi:10.1016/j.pcd.2014.06.002

    Article  PubMed  Google Scholar 

  9. Alghamdi F, Guo M, Abdulkhalek S, Crawford N, Amith SR, Szewczuk MR (2014) A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes. Cell Signal 26(4):1355–1368. doi:10.1016/j.cellsig.2014.02.015

    Article  CAS  PubMed  Google Scholar 

  10. Aminoff D (1961) Methods for the qualitative estimation of Nacetylneuraminic acid and their application to hydrolysis of sialomucoids. Biochem J 81:384–392

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. Ward C, Lawrence M, Streltsov V, Garrett T, McKern N, Lou MZ, Lovrecz G, Adams T (2008) Structural insights into ligand-induced activation of the insulin receptor. Acta Physiol (Oxf) 192(1):3–9. doi:10.1111/j.1748-1716.2007.01781.x

    Article  CAS  Google Scholar 

  12. Sparrow LG, Lawrence MC, Gorman JJ, Strike PM, Robinson CP, McKern NM, Ward CW (2008) N-linked glycans of the human insulin receptor and their distribution over the crystal structure. Proteins 71(1):426–439

    Article  CAS  PubMed  Google Scholar 

  13. Gokmen SS, Kilicli G, Ozcelik F, Ture M, Gulen S (2002) Association between serum total and lipid-bound sialic acid concentration and the severity of coronary atherosclerosis. J Lab Clin Med 140(2):110–118

    Article  CAS  PubMed  Google Scholar 

  14. Lapolla A, Molin L, Traldi P (2013) Protein glycation in diabetes as determined by mass spectrometry. Int J Endocrinol. Article ID 412103. doi: 10.1155/2013/412103

  15. Crook MA, Tutt P, Simpson H, Pickup JC (1993) Serum sialic acid and acute phase proteins in type 1 and type 2 diabetes mellitus. Clin Chim Acta 219:131–138

    Article  CAS  PubMed  Google Scholar 

  16. Crook MA, Khandhadia S, Lumb P, Ridha A, Hussain A (2000) No difference in serum sialic acid in type 2 diabetic patients from the United Arab Emirates with or without diabetic retinopathy. Diabetes Res Clin Pract 47:147–150

    Article  CAS  PubMed  Google Scholar 

  17. Hininger-Favier I, Benaraba R, Coves S, Anderson RA (2009) Green tea extract decrease oxidative stress and improved insulin sensitivity in an animal model of insulin resistance, the fructose-fed rat. J Am Coll Nutr 28:355–361

    Article  CAS  PubMed  Google Scholar 

  18. Wilson R, Islam MS (2012) Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes. Pharmacol Rep 64:129–139

    Article  CAS  PubMed  Google Scholar 

  19. Leahy JL (2005) Pathogenesis of type 2 diabetes Mellitus. Arch Med Res 36:197–209

    Article  CAS  PubMed  Google Scholar 

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Acknowledgment

The management of Ahmadu Bello University, Zaria, Nigeria is acknowledged for providing the materials used for the study. This study was also supported, in part, by the Education Trust Fund-ABU desk office (Grant No.: ETF/DESS/AST&D/ABU ZARIA).

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Authors and Affiliations

  1. Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria

    Mohammed Auwal Ibrahim, Aisha Abdulkadir, Alice Onojah, Lawal Sani, Auwal Adamu & Hadiza Abdullahi

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  1. Mohammed Auwal Ibrahim
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  2. Aisha Abdulkadir
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  3. Alice Onojah
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  4. Lawal Sani
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Correspondence to Mohammed Auwal Ibrahim.

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Ibrahim, M.A., Abdulkadir, A., Onojah, A. et al. Modulation of sialic acid levels among some organs during insulin resistance or hyperglycemic states. Mol Cell Biochem 411, 235–239 (2016). https://doi.org/10.1007/s11010-015-2585-x

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  • DOI: https://doi.org/10.1007/s11010-015-2585-x

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