Abstract
Purpose
To compare the central corneal thickness (CCT) measurements and reliability of RTVue XR-100 anterior segment optical coherence tomography (AS-OCT), AL-scan optical biometer and Schwind Sirius anterior segment analysis system.
Methods
The CCT was measured in one hundred and twenty-seven eyes of 127 healthy subjects with AS-OCT, AL-scan and Sirius system. Mean CCT was compared among the instruments, and the level of agreement was assessed using Bland–Altman plots. One eye each of 30 subjects was randomly assigned for intrasession intraoperator and interoperator repeatability which was assessed using coefficient of variation and intraclass correlation coefficient.
Results
Mean CCT with AS-OCT, AL-scan and Sirius system was 496.72 ± 32.75, 507.43 ± 33.54 and 512.08 ± 33.1 µm, respectively. There was no statistically significant difference between AL-scan and Sirius system (p = 0.26). Significant difference was found between AS-OCT/AL-scan (p = 0.01) and AS-OCT/Sirius system (p < 0.0001). Bland–Altman analysis showed a high level of agreement between AL-Scan/Sirius system (Mean difference −4.6 µm) and a low level of agreement between AS-OCT/AL-scan (Mean difference −10.7 µm) and OCT/Sirius system (Mean difference −15.4 µm).
Conclusions
AS-OCT underestimated CCT measurements when compared to other two devices in healthy subjects. Hence, one must be cautious when analyzing the results from different machines and should be aware that the measurement values are not interchangeable.
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References
Seiler T, Koufala K, Richter G (1998) Iatrogenic keratectasia after laser in situ keratomileusis. J Refract Surg 14:312–317
Thomas R, Korah S, Muliyil J (2000) The role of central corneal thickness in the diagnosis of glaucoma. Indian J Ophthalmol 48:107–111
Doughty MJ, Zaman ML (2000) Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol 44:367–408
Bayhan HA, Bayhan SA, Can I (2014) Comparison of central corneal thickness measurements with three new optical devices and a standard ultrasonic pachymeter. Int J Ophthalmol 7:302–308
Nam SM, Im CY, Lee HK, Kim EK, Kim TI, Seo KY (2010) Accuracy of RTVue optical coherence tomography, Pentacam, and ultrasonic pachymetry for the measurement of central corneal thickness. Ophthalmology 117:2096–2103
Zhao PS, Wong TY, Wong WL, Saw SM, Aung T (2007) Comparison of central corneal thickness measurements by visante anterior segment optical coherence tomography with ultrasound pachymetry. Am J Ophthalmol 143:1047–1049
Ishibazawa A, Igarashi S, Hanada K, Nagaoka T, Ishiko S, Ito H et al (2011) Central corneal thickness measurements with Fourier-domain optical coherence tomography versus ultrasonic pachymetry and rotating Scheimpflug camera. Cornea 30:615–619
Li EY, Mohamed S, Leung CK, Rao SK, Cheng AC, Cheung CY et al (2007) Agreement among 3 methods to measure corneal thickness: ultrasound pachymetry, Orbscan II, and Visante anterior segment optical coherence tomography. Ophthalmology 114:1842–1847
Li H, Leung CK, Wong L, Cheung CY, Pang CP, Weinreb RN et al (2008) Comparative study of central corneal thickness measurement with slit-lamp optical coherence tomography and visante optical coherence tomography. Ophthalmology 115:796–801
Milla M, Piñero DP, Amparo F, Alió JL (2011) Pachymetric measurements with a new Scheimpflug photography-based system: intraobserver repeatability and agreement with optical coherence tomography pachymetry. J Cataract Refract Surg 37:310–316
Huang J, Ding X, Savini G, Jiang Z, Pan C, Hua Y et al (2014) Central and midperipheral corneal thickness measured with Scheimpflug imaging and optical coherence tomography. PLoS ONE 9:e98316. doi:10.1371/journal.pone.0098316 (eCollection 2014)
Huang J, Ding X, Savini G, Pan C, Feng Y, Cheng D et al (2013) A comparison between Scheimpflug imaging and optical coherence tomography in measuring corneal thickness. Ophthalmology 120:1951–1958
Yazici AT, Bozkurt E, Alagoz C, Alagoz N, Pekel G, Kaya V et al (2010) Central corneal thickness, anterior chamber depth, and pupil diameter measurements using Visante OCT, Orbscan, and Pentacam. J Refract Surg 26:127–133
Shimmyo M, Ross AJ, Moy A, Mostafavi R (2003) Intraocular pressure, Goldmann applanation tension, corneal thickness, and corneal curvature in Caucasians, Asians, Hispanics, and African Americans. Am J Ophthalmol 136:603–613
Aghaian E, Choe JE, Lin S, Stamper RL (2004) Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic. Ophthalmology 111:2211–2219
Vijaya L, George R, Baskaran M, Arvind H, Raju P, Ramesh SV et al (2008) Prevalence of primary open-angle glaucoma in an urban south Indian population and comparison with a rural population. The Chennai Glaucoma Study. Ophthalmology. 115:648–654
Nangia V, Jonas JB, Sinha A, Matin A, Kulkarni M (2010) Central corneal thickness and its association with ocular and general parameters in Indians: the Central India eye and medical study. Ophthalmology 117:705–710
Rochtchina E, Mitchell P, Wang JJ (2002) Relationship between age and intraocular pressure: the Blue Mountains Eye Study. Clin Exp Ophthalmol 30:173–175
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Mansoori, T., Balakrishna, N. Repeatability and agreement of central corneal thickness measurement with non-contact methods: a comparative study. Int Ophthalmol 38, 959–966 (2018). https://doi.org/10.1007/s10792-017-0543-1
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DOI: https://doi.org/10.1007/s10792-017-0543-1