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Increased Expression of T Cell Immunoglobulin and Mucin Domain 4 Is Positively Associated with the Disease Severity of Patients with Ankylosing Spondylitis

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Abstract

Monocytes and associated cytokines have been shown to be involved in the pathogenesis of ankylosing spondylitis (AS). T cell immunoglobulin and mucin domain 4 (Tim-4) was identified on monocytes/macrophages and dentritic cells (DCs) and plays important roles in regulating the activities of macrophages and DCs. The current study investigated the association between Tim-4 expression and AS. Our results showed that Tim-4 expression on monocytes and Tim-4 level in plasma were highly increased in AS patients than in controls. Furthermore, TNF-α production and bath ankylosing spondylitis disease activity index (BASDAI) have positive relationships with Tim-4 expression in AS patients. High expression of Tim-4 was thought to contribute to the pathogenesis and an underlying mechanism of AS.

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ACKNOWLEDGMENTS

This research was supported by a grant from the Zhejiang Provincial Natural Science Foundation of China (No. LQ13H100001).

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The authors have no financial interests to disclose.

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Authors and Affiliations

  1. Cell and Molecular Biology Laboratory, Zhoushan Hospital, No. 739, Dingshen Road, Lincheng Street, Dinghai District, Zhoushan City, 316000, Zhejiang Province, People’s Republic of China

    Dongdong Chen, Jianying He, Changchang Lu, Jihang Zhou, Kexin Fang, Xiaoguang Liu & Liyun Xu

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  1. Dongdong Chen
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  2. Jianying He
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  3. Changchang Lu
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  4. Jihang Zhou
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  6. Xiaoguang Liu
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  7. Liyun Xu
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Correspondence to Liyun Xu.

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Chen, D., He, J., Lu, C. et al. Increased Expression of T Cell Immunoglobulin and Mucin Domain 4 Is Positively Associated with the Disease Severity of Patients with Ankylosing Spondylitis. Inflammation 38, 935–940 (2015). https://doi.org/10.1007/s10753-014-0055-3

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