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Do diethyl phthalate (DEP) and di-2-ethylhexyl phthalate (DEHP) influence the metabolic syndrome parameters? Pilot study

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Abstract

The study objective was to determine if the healthy participants were exposed to diethyl phthalate (DEP) and di (2-ethylhexyl) phthalate (DEHP) and if this exposure could be linked to the development of metabolic syndrome. The study included 103 healthy volunteers of similar age with normal BMI values, waist circumference, total cholesterol, HDL, LDL, and triglycerides. DEP and DEHP were measured in the morning urine samples to detect monoethyl phthalate (MEP) and mono-2-ethylhexyl phthalate (MEHP). Two phthalate groups and a control group were formed. Both MEP group and control group had similar results. The correlations between MEP and the measured parameters were insignificant. The correlation between the MEHP group and the age was significantly negative, but between the MHEP group and the waist circumference the correlation was significantly positive. Lipids and lipoproteins were within the reference values and equal in both groups. The significant negative correlation was observed only between MEHP and HDL. Our population is exposed to DEP and DEHP. There was only a significant correlation between DEHP and the observed metabolic syndrome components. Its negative impact was higher as the participants were younger.

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Acknowledgments

This research has been financially supported by the Provincial Secretariat for Science and Technological Development, AP Vojvodina, Republic of Serbia, Grant No. 114-451-1094/2014.

Conflicts of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Faculty of Medicine, Clinical Centre of Vojvodina, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University of Novi Sad, Hajduk Veljkova 1, 21000, Novi Sad, Serbia

    Milica Medic Stojanoska, Andrijana Milankov, Bojan Vukovic, Ivana Bajkin, Tijana Icin & Branka Kovacev Zavisic

  2. Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia

    Dejan Vukcevic

  3. Faculty of Medicine, Department of Pharmacy, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia

    Jan Sudji & Natasa Milic

  4. Faculty of Medicine, Clinical Centre of Vojvodina, Centre for Laboratory Medicine, University of Novi Sad, Hajduk Veljkova 1, 21000, Novi Sad, Serbia

    Nikola Curic

Authors
  1. Milica Medic Stojanoska
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  2. Andrijana Milankov
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  3. Bojan Vukovic
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  4. Dejan Vukcevic
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  5. Jan Sudji
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  6. Ivana Bajkin
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  7. Nikola Curic
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  8. Tijana Icin
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  9. Branka Kovacev Zavisic
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  10. Natasa Milic
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Correspondence to Milica Medic Stojanoska.

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Medic Stojanoska, M., Milankov, A., Vukovic, B. et al. Do diethyl phthalate (DEP) and di-2-ethylhexyl phthalate (DEHP) influence the metabolic syndrome parameters? Pilot study. Environ Monit Assess 187, 526 (2015). https://doi.org/10.1007/s10661-015-4754-5

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