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Food-Induced Acute Pancreatitis

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Abstract

Food allergy, a commonly increasing problem worldwide, defined as an adverse immune response to food. A variety of immune-related effector cells such as mast cells, eosinophils, neutrophils, and T cells are involved in food-related allergic responses categorized as IgE mediated, non-IgE mediated, and mixed (IgE and non-IgE) depending upon underlying immunological mechanisms. The dietary antigens mainly target the gastrointestinal tract including pancreas that gets inflamed due to food allergy and leads acute pancreatitis. Reports indicate several food proteins induce pancreatitis; however, detailed underlying mechanism of food-induced pancreatitis is unexplored. The aim of the review is to understand and update the current scenario of food-induced pancreatitis. A comprehensive literature search of relevant research articles has been performed through PubMed, and articles were chosen based on their relevance to food allergen-mediated pancreatitis. Several cases in the literature indicate that acute pancreatitis has been provoked after the consumption of mustard, milk, egg, banana, fish, and kiwi fruits. Food-induced pancreatitis is an ignored and unexplored area of research. The review highlights the significance of food in the development of pancreatitis and draws the attention of physicians and scientists to consider food allergies as a possible cause for initiation of pancreatitis pathogenesis.

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Acknowledgments

Dr. Mishra is the Endowed Schlieder Chair; therefore, authors thank Edward G. Schlieder Educational Foundation for the support.

Funding

Funding was provided by National Institutes of Health (R01 AI080581).

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Author notes

  1. Murli Manohar and Alok K. Verma have contributed equally to this work.

Authors and Affiliations

  1. Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA

    Murli Manohar, Alok K. Verma, Sathisha Upparahalli Venkateshaiah & Anil Mishra

  2. Department of Internal Medicine, Mercer University School of Medicine, 707 Pine St., Macon, GA, 31201, USA

    Hemant Goyal

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  1. Murli Manohar
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Correspondence to Anil Mishra.

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Manohar, M., Verma, A.K., Upparahalli Venkateshaiah, S. et al. Food-Induced Acute Pancreatitis. Dig Dis Sci 62, 3287–3297 (2017). https://doi.org/10.1007/s10620-017-4817-2

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