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Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury

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Abstract

Of the numerous gaseous substances that can act as signaling molecules, the best characterized are nitric oxide, carbon monoxide and hydrogen sulfide. Contributions of each of these low molecular weight substances, alone or in combination, to maintenance of gastrointestinal mucosal integrity have been established. There is considerable overlap in the actions of these gases in modulating mucosal defense and responses to injury, and in some instances they act in a cooperative manner. Each also play important roles in regulating inflammatory and repair processes throughout the gastrointestinal tract. In recent years, significant progress has been made in the development of novel anti-inflammatory and cytoprotective drugs that exploit the beneficial activities of one or more of these gaseous mediators.

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Acknowledgments

Dr. Wallace’s research is supported by a grant from the Canadian Institutes of Health Research.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada

    John L. Wallace

  2. Department of Medicine, Universidade Camilo Castelo Branco, Fernandopolis, SP, Brazil

    John L. Wallace & Gilberto de Nucci

  3. Department of Experimental Pharmacology, University of Naples, Naples, Italy

    Angela Ianaro

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Correspondence to John L. Wallace.

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Dr. Wallace is the founder and Chief Scientific Officer of Antibe Therapeutics Inc., which is developing hydrogen sulfide-releasing drugs.

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Wallace, J.L., Ianaro, A. & de Nucci, G. Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury. Dig Dis Sci 62, 2223–2230 (2017). https://doi.org/10.1007/s10620-017-4681-0

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