Skip to main content
Log in

Role of linoleic acid-derived oxylipins in cancer

  • Commentary
  • Published:
Cancer and Metastasis Reviews Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Bjermo, H., Iggman, D., Kullberg, J., Dahlman, I., Johansson, L., Persson, L., Berglund, J., Pulkki, K., Basu, S., Uusitupa, M., Rudling, M., Arner, P., Cederholm, T., Ahlström, H., & Risérus, U. (2012). Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial. The American Journal of Clinical Nutrition, 95(5), 1003–1012.

    Article  CAS  Google Scholar 

  2. Ramsden, C. E., Zamora, D., Majchrzak-Hong, S., et al. (2016). Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). BMJ, 353, i1246.

    Article  Google Scholar 

  3. Spector, A. A., & Kim, H. Y. (2015). Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism. Biochimica et Biophysica Acta, 1851(4), 356–365.

    Article  CAS  Google Scholar 

  4. Edin, M. L., Hamedani, B. G., Gruzdev, A., Graves, J. P., Lih, F. B., Arbes III, S. J., Singh, R., Orjuela Leon, A. C., Bradbury, J. A., DeGraff, L. M., Hoopes, S. L., Arand, M., & Zeldin, D. C. (2018). Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia. The Journal of Biological Chemistry, 293(9), 3281–3292.

    Article  CAS  Google Scholar 

  5. Panigrahy, D., Edin, M. L., Lee, C. R., Huang, S., Bielenberg, D. R., Butterfield, C. E., Barnés, C. M., Mammoto, A., Mammoto, T., Luria, A., Benny, O., Chaponis, D. M., Dudley, A. C., Greene, E. R., Vergilio, J. A., Pietramaggiori, G., Scherer-Pietramaggiori, S. S., Short, S. M., Seth, M., Lih, F. B., Tomer, K. B., Yang, J., Schwendener, R. A., Hammock, B. D., Falck, J. R., Manthati, V. L., Ingber, D. E., Kaipainen, A., D’Amore, P. A., Kieran, M. W., & Zeldin, D. C. (2012). Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. The Journal of Clinical Investigation, 122(1), 178–191.

    Article  CAS  Google Scholar 

  6. Spiecker, M., Darius, H., Hankeln, T., Soufi, M., Sattler, A. M., Schaefer, J.̈. R., Node, K., Börgel, J., Mügge, A., Lindpaintner, K., Huesing, A., Maisch, B., Zeldin, D. C., & Liao, J. K. (2004). Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. Circulation, 110(15), 2132–2136.

  7. Wang, W., Sanidad, K. Z., & Zhang, G. (2019). Cytochrome P450 eicosanoid signaling pathway in colorectal tumorigenesis. Advances in Experimental Medicine and Biology, 1161, 115–123.

    Article  CAS  Google Scholar 

  8. Hada, M., Edin, M. L., Hartge, P., Lih, F. B., Wentzensen, N., Zeldin, D. C., & Trabert, B. (2019). Prediagnostic serum levels of fatty acid metabolites and risk of ovarian cancer in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial. Cancer Epidemiology, Biomarkers & Prevention, 28(1), 189–197.

    Article  Google Scholar 

  9. Wang, W., Yang, J., Edin, M. L., Wang, Y., Luo, Y., Wan, D., Yang, H., Song, C. Q., Xue, W., Sanidad, K. Z., Song, M., Bisbee, H. A., Bradbury, J. A., Nan, G., Zhang, J., Shih, P. A. B., Lee, K. S. S., Minter, L. M., Kim, D., Xiao, H., Liu, J. Y., Hammock, B. D., Zeldin, D. C., & Zhang, G. (2019). Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis. Cancer Research, 79(8), 1822–1830.

    Article  CAS  Google Scholar 

  10. Zhang, W., Li, H., Dong, H., Liao, J., Hammock, B. D., & Yang, G. Y. (2013). Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice. Anticancer Research, 33(12), 5261–5271.

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Zhang, W., Yang, A. L., Liao, J., Li, H., Dong, H., Chung, Y. T., Bai, H., Matkowskyj, K. A., Hammock, B. D., & Yang, G. Y. (2012). Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice. Digestive Diseases and Sciences, 57(10), 2580–2591.

    Article  CAS  Google Scholar 

  12. Zhang, W., Liao, J., Li, H., Dong, H., Bai, H., Yang, A., Hammock, B. D., & Yang, G. Y. (2013). Reduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency. Molecular Carcinogenesis, 52(9), 726–738.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This research is supported by USDA NIFA 2019-67017-29248 and NIH/NCI R03CA218520 (to G.Z.) and the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences Z01 ES025034 (to D.C.Z.).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Darryl C. Zeldin.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Edin, M.L., Duval, C., Zhang, G. et al. Role of linoleic acid-derived oxylipins in cancer. Cancer Metastasis Rev 39, 581–582 (2020). https://doi.org/10.1007/s10555-020-09904-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10555-020-09904-8

Navigation