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The effect of different treatment strategies on left ventricular myocardial deformation parameters in patients with chronic renal failure

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Abstract

The aim of this study was to compare left ventricular (LV) functions by speckle tracking echocardiography (STE) in chronic kidney disease (CKD) patients in various stages and under different renal replacement treatments in order to evaluate possible differences between them. This prospective study included 150 patients with CKD. Renal transplantation patients with glomerular filtration rate greater than 60 ml/min/1.73 m2, patients receiving hemodialysis three times a week, and patients in the predialysis stage with glomerular filtration rate less than 30 ml/dk/1.73 m2 were assigned into Group 1 (n = 50), Group 2 (n = 50), and Group 3 (n = 50), respectively. LV longitudinal, circumferential, and radial myocardial deformation parameters (strain, strain rate [SR], rotation, twist) were evaluated by STE. Peak systolic longitudinal strain was higher in the transplantation group than the hemodialysis group (− 19.93 ± 3.50 vs − 17.47 ± 3.28%, p < 0.017). Peak systolic circumferential strain was lower in the hemodialysis group (− 20.97 ± 4.90%) than Groups 1 and 3 (− 25.87 ± 4.20 and − 24.74 ± 4.55%, respectively, p < 0.001). Peak systolic radial SR was higher in the transplantation group than the hemodialysis group (1.84 ± 0.52 vs 1.55 ± 0.52 s−1, respectively, p < 0.017). Other longitudinal and circumferential deformation parameters together with peak early diastolic radial SR and twist were also significantly different between the groups. Strain, SR, and twist values were mostly lower in the hemodialysis patients, but generally higher in the transplantation patients. LV functions evaluated by STE are better in the renal transplantation patients than the hemodialysis patients and than those in the predialysis stage. This may indicate beneficial effects of renal transplantation on cardiac functions.

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Funding

This study was funded by the Ondokuz Mayis University, Samsun, Turkey (Project Number: PYO.TIP.1904.13.030).

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Authors and Affiliations

  1. Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

    Ufuk Yildirim, Okan Gulel & Mahmut Sahin

  2. Cardiology Clinic, Ataturk State Hospital, Zonguldak, Turkey

    Alay Eksi

  3. Department of Nephrology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

    Melda Dilek

  4. Department of Cardiology, Faculty of Medicine, Bilim University, Istanbul, Turkey

    Sabri Demircan

Authors
  1. Ufuk Yildirim
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  2. Okan Gulel
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  3. Alay Eksi
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  4. Melda Dilek
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  5. Sabri Demircan
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  6. Mahmut Sahin
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Correspondence to Okan Gulel.

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The authors declare that they have no competing interests.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Yildirim, U., Gulel, O., Eksi, A. et al. The effect of different treatment strategies on left ventricular myocardial deformation parameters in patients with chronic renal failure. Int J Cardiovasc Imaging 34, 1731–1739 (2018). https://doi.org/10.1007/s10554-018-1390-5

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  • DOI: https://doi.org/10.1007/s10554-018-1390-5

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