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Changes in Hemostasis System in Outbred Female Mice with Cisplatin-Induced Procoagulant Status

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Procoagulant status was modeled in outbred female mice by single injection of cisplatin in a maximum tolerated dose and hemostasis parameters monitored over 30 days by methods of coagulogram and low-frequency piezothromboelastography (global test). Monitoring revealed waveform changes in the hemostatic potential: the structural and chronometric hypercoagulation recorded starting from the first day and attaining its maximum on days 5-7 was followed by hypocoagulation and returned to normocoagulation on day 30. This pattern reflects prolonged effect of cisplatin: formation of severe dysfunction of the endothelium providing the main anticoagulant pool of hemostasis (day 1) aggravated by disturbances of the plastic functions of the liver (days 15-20), and recovery (days 20-30).

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    M. V. Filonova, E. P. Fedorova, A. A. Churin, L. Yu. Kotlovskaya, M. A. Solov’ev & V. V. Udut

  2. National Research Tomsk State University, Tomsk, Russia

    M. V. Filonova, A. A. Churin, L. Yu. Kotlovskaya & V. V. Udut

Authors
  1. M. V. Filonova
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  2. E. P. Fedorova
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  3. A. A. Churin
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  4. L. Yu. Kotlovskaya
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  5. M. A. Solov’ev
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  6. V. V. Udut
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Correspondence to M. V. Filonova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 7, pp. 21-25, July, 2020

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Filonova, M.V., Fedorova, E.P., Churin, A.A. et al. Changes in Hemostasis System in Outbred Female Mice with Cisplatin-Induced Procoagulant Status. Bull Exp Biol Med 170, 15–18 (2020). https://doi.org/10.1007/s10517-020-04995-3

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  • DOI: https://doi.org/10.1007/s10517-020-04995-3

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