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The emerging role of Acid Sphingomyelinase in autophagy

  • THE ROLE OF SPHINGOLIPIDS AND LIPID RAFTS IN DETERMINING CELL FATE
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Abstract

Autophagy, the main intracellular process of cytoplasmic material degradation, is involved in cell survival and death. Autophagy is regulated at various levels and novel modulators of its function are being continuously identified. An intriguing recent observation is that among these modulators is the sphingolipid metabolising enzyme, Acid Sphingomyelinase (A-SMase), already known to play a fundamental role in apoptotic cell death participating in several pathophysiological conditions. In this review we analyse and discuss the relationship between autophagy and A-SMase describing how A-SMase may regulate it and defining, for the first time, the existence of an A-SMase-autophagy axis. The imbalance of this axis plays a role in cancer, nervous system, cardiovascular, and hepatic disorders.

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Acknowledgments

This work was supported by “Ministero della Salute, Giovani Ricercatori 2011–2012” Grant to C.D.P. and “Ricerca corrente 2015” Grant to E.C.; “Ministero dell’Istruzione, Università e Ricerca, PRIN2010-2011” Grants to E.C. and D.C.; “Università di Milano, Giovani Ricercatori-Linea B” Grant to C.P.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences “Luigi Sacco” (DIBIC), National Research Council-Institute of Neuroscience, University Hospital “Luigi Sacco”, Università di Milano, 20157, Milan, Italy

    Cristiana Perrotta, Davide Cervia, Clara De Palma, Paolo Pellegrino & Emilio Clementi

  2. Department for Innovation in Biological, Agro-food and Forest Systems (DIBAF), Università della Tuscia, 01100, Viterbo, Italy

    Davide Cervia

  3. Scientific Institute IRCCS Eugenio Medea, 23842, Bosisio Parini, Italy

    Emma Assi, Maria Teresa Bassi & Emilio Clementi

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  1. Cristiana Perrotta
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  2. Davide Cervia
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  3. Clara De Palma
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  4. Emma Assi
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  7. Emilio Clementi
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Correspondence to Emilio Clementi.

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Perrotta, C., Cervia, D., De Palma, C. et al. The emerging role of Acid Sphingomyelinase in autophagy. Apoptosis 20, 635–644 (2015). https://doi.org/10.1007/s10495-015-1101-9

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