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Analysis of survival rates and prognostic factors among patients with oral squamous cell carcinoma

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Abstract

Aim: The aim of the study was to estimate global and accumulated survival rates as well as prognostic factors among patients with oral squamous cell carcinoma (OSCC). Subject and methods: Data from the previous 5 years were extracted from patient charts at a cancer reference center. The occurrence of death resulting from the malignant tumor in patients with a diagnosis of OSCC was the dependent variable. The independent variables were tumor site, degree of cell differentiation, clinical staging, data of histopathological determination of OSCC, socio-demographic characteristics, smoking habit and treatment modality. Kaplan-Meier survival curves were created. Differences were analyzed using the log-rank and Wilcoxon tests. The Cox regression model was employed to evaluate factors associated with survival, with the calculation of hazard ratios (HR) (α = 5%). Results: The global survival rate was 57%. The stage of the tumor exercised a direct influence on accumulated survival. In the first year of evaluation, the survival rate of patients in stages I and II was 92.6%. The Cox regression analysis revealed the following variables to be significantly associated with survival: T classification of the clinical staging (HR = 2.283; 95% CI: 1.115–4.673) and degree of tumor invasion (HR = 1.834; 95% CI: 1.041–3.232). Conclusion: Clinical stage and degree of tumor invasion are important prognostic factors for OSCC.

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Authors and Affiliations

  1. Department of Dentistry, State University of Paraíba, 1325/410 Capitão João Alves de Lira, 58428-800, Campina Grande, PB, Brazil

    Tony Santos Peixoto, Monalisa Cesarino Gomes, Daliana Queiroga de Castro Gomes, Ana Flávia Granville-Garcia & Edja Maria Melo de Brito Costa

  2. Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil

    Kênio Costa Lima

Authors
  1. Tony Santos Peixoto
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  2. Monalisa Cesarino Gomes
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  3. Daliana Queiroga de Castro Gomes
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  4. Kênio Costa Lima
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  5. Ana Flávia Granville-Garcia
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  6. Edja Maria Melo de Brito Costa
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Correspondence to Ana Flávia Granville-Garcia.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Peixoto, T.S., Gomes, M.C., de Castro Gomes, D.Q. et al. Analysis of survival rates and prognostic factors among patients with oral squamous cell carcinoma. J Public Health 25, 433–441 (2017). https://doi.org/10.1007/s10389-017-0794-3

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  • DOI: https://doi.org/10.1007/s10389-017-0794-3

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