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Detection of the early phase of esophageal cancer progression into lamina propria mucosae by the serum p53 antibody

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Abstract

Eight years after surgical treatment for breast cancer, serum p53 antibody levels suddenly increased in a 67-year-old woman without recurrent signs of cancer. Early esophageal squamous cell carcinoma was detected by endoscopic screening. After endoscopic submucosal dissection was completed, serum p53 antibody levels decreased to be in the normal range. Serum p53 antibody monitoring can be helpful for early detection of not only recurrence of primary carcinoma but also development of metachronous carcinoma. This case is the first to monitor the changing titers of serum p53 antibody at the early phase of esophageal cancer progression into lamina propria mucosae until the disappearance of tumor cells.

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Abbreviations

SCC:

Squamous cell carcinoma

s-p53-Abs:

Serum p53 antibodies

CEA:

Carcinoembryonic antigen

ESD:

Endoscopic submucosal dissection

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Author information

Authors and Affiliations

  1. Department of Surgery, School of Medicine, Toho University Omori Medical Center, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan

    Fumi Saito, Hideaki Shimada, Hideaki Ogata & Hironori Kaneko

  2. Division of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan

    Takafumi Otsuka

  3. Department of Surgical Pathology, School of Medicine, Toho University, Tokyo, Japan

    Tetsuo Nemoto & Kazutoshi Shibuya

Authors
  1. Fumi Saito
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  2. Hideaki Shimada
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  3. Hideaki Ogata
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  4. Takafumi Otsuka
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  5. Tetsuo Nemoto
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  6. Kazutoshi Shibuya
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  7. Hironori Kaneko
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Corresponding author

Correspondence to Hideaki Shimada.

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Ethical Statement

This study was performed in accordance with the Declaration of Helsinki and was approved by the ethics committee of Toho University Hospital (#21-93, 24-001, 26-256).

Conflict of interest

All authors have no conflict of interest.

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Saito, F., Shimada, H., Ogata, H. et al. Detection of the early phase of esophageal cancer progression into lamina propria mucosae by the serum p53 antibody. Esophagus 14, 366–369 (2017). https://doi.org/10.1007/s10388-016-0564-2

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  • DOI: https://doi.org/10.1007/s10388-016-0564-2

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