Abstract
Boundary extraction of carpal bone images is a critical operation of the automatic bone age assessment system, since the contrast between the bony structure and soft tissue are very poor. In this paper, we present an edge following technique for boundary extraction in carpal bone images and apply it to assess bone age in young children. Our proposed technique can detect the boundaries of carpal bones in X-ray images by using the information from the vector image model and the edge map. Feature analysis of the carpal bones can reveal the important information for bone age assessment. Five features for bone age assessment are calculated from the boundary extraction result of each carpal bone. All features are taken as input into the support vector regression (SVR) that assesses the bone age. We compare the SVR with the neural network regression (NNR). We use 180 images of carpal bone from a digital hand atlas to assess the bone age of young children from 0 to 6 years old. Leave-one-out cross validation is used for testing the efficiency of the techniques. The opinions of the skilled radiologists provided in the atlas are used as the ground truth in bone age assessment. The SVR is able to provide more accurate bone age assessment results than the NNR. The experimental results from SVR are very close to the bone age assessment by skilled radiologists.
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Tanner JM, Whitehouse RH: Assessment of skeletal maturity and prediction of adult height (TW2 Method). Academic Press, New York, 1975
Kirks D: Practical Pediatric Imaging, Diagnostic Radiology of Infants and Children. Lippincott Williams & Wilkins, Philadelphia, 1984
Greulich WW: Pyle SI: Radiographic Atlas of Skeletal Development of Hand Wrist. Stanford University Press, CA, 1971
Pietka E, Gertych A, Pospiech S, Cao F, Huang HK, Gilsanz V: Computer-assisted bone age assessment: graphical user interface for image processing and comparison. J Digit Imaging 17:175–188, 2004
Pietka E, Gertych A, Pospiech S, Cao F, Huang HK, Gilsanz V: Computer-assisted bone age assessment: image preprocessing and epiphyseal/metaphyseal ROI extraction. IEEE Trans Medical Imaging 20:715–729, 2001
Pietka E, Kaabi L, Kuo ML, Huang HK: Feature extraction in carpal-bone analysis. IEEE Trans Medical Imaging 12:44–49, 1993
Liu J, Qi J, Liu Z, Ning Q, Luo X: Automatic bone age assessment based on intelligent algorithms and comparison with TW3 method. Comput Med Imaging Graph 32:678–884, 2008
Lin P, Zhang F, Yang Y, Zheng C: Carpal-bone feature extraction analysis in skeletal age assessment based on deformable model. JCS&T 4:152–156, 2004
Lin P, Zheng C, Zhang F, Yang Y: X-ray carpal-bone image boundary feature analysis using region statistical feature based level set method for skeletal age assessment application. Optica Applicata 2:283–294, 2005
Ko CC, Mao CW, Lin CJ, Sun YN: Image analysis for skeletal evaluation of carpal bones. Proc SPIE 2501:951–61, 1995
Parker JR: Algorithms for image processing and computer vision. Wiley, New York, 1997
Robinson GS: Edge detection by compass gradient masks. Compute Graph Image Process 6:492–501, 1977
Argyle E: Techniques for edge detection. In: Proc. IEEE, 1970. pp 258–287
Gonzalez RC, Woods RE: Digital image processing. Addison Wesley, Reading, 1992
Leymarie F, Levine MD: Tracking deformable objects in the plane using an active contour model. IEEE Trans Pattern Anal and Machine Intell 15:617–634, 1993
Kass M, Witken A, Terzopoulos D: Snakes: active contour model. Int J Comput Vis 1:321–331, 1988
Caselles V, Catte F, Coll T, Dibos F: A geometric model for active contours. Numer Math 66:1–31, 1993
Jong DP, Kim S, Lee DS, Lee HL: The segmentation of computed tomography using the geometric active contour model. J Digit Imaging 11(3):209, 1998
Xu C, Prince JL: Gradient vector flow: a new external force for snake. In: IEEE Proc Conf on Comput Vis Pattern Recog, 1997. pp 66–71
Xu C, Prince JL: Snakes, shapes and gradient vector flow. In: IEEE Trans Image Process, 7, 1998. pp 359–369
Ballerini L: Genetic snakes for medical images segmentation. Lect Notes Comput Sci 2037:268–277, 2001
Caro A, Rodriguez PG, Cernadas E, Duran ML, Antequera T: Potential field as and external force and algorithmic improvements in deformable models. Electronic Letters on Comput Vis and Image Anal 2:25–36, 2003
Sagiv C, Sochen N, Zeevi YY: Integrated active contours for texture segmentation. In: IEEE Trans Image Process, 2006
Zhou JY, Fang W, Chan KL, Chong VF, Khoo JB: Extraction of metastatic lymph nodes from MR images using two deformable model-based approaches. J Digit Imaging 20(4):336–346, 2007
Truc PT, Kum TS, Lee S, Lee YK: A study on the feasibility of active contour on automatic CT bone segmentation. J Digit Imaging 23(6):793–805, 2009
Johnston FE, Jahina SB: The contribution of the carpal bones to the assessment of skeletal age. Amer J Phys Anthrop 23:349–354, 1965
Somkantha S, Theera-Umpon N, Auephanwiriyakul S: Left ventricular segmentation of cardiac magnetic resonance images using a novel edge following technique. In: IEEE Intl Conf on Cybernetics and Intelligence System, 2008. pp 169–174
Vapnik VN: The Nature of Statistical Learning Theory. Springer, New York, 1995
Gunn S: Support Vector Machines for Classification and Regression, Image Speed & Intelligent Systems Research Group, University of Southampton, 1998
Smola AJ, Scholkopf B: A Tutorial on support vector regression. Statistics and Computing 14(3):199–222, 2004
Gilsanz V, Ratib O: Hand Bone Age: A Digital Atlas of Skeletal Maturity, 2005
Gertych A, Zhang A, Sayre J, Pospiech-Kurkowska S, Huang HK: Bone age assessment of children using a digital hand atlas. Comput Med Imaging Graph 31:322–331, 2007
University of Southern California, Image Processing and Informatics Lab: Digital Hand Atlas Database System. Available at: http://ipilab.org/BAAweb/
Eua-Anant N, Udpa L: A novel boundary extraction algorithm based on a vector image model. IEEE Proceeding, 1997. pp 597–600
Laws KI: Textured Image Segmentation, Ph.D. dissertation, University of Southern California, 1980
Canny J: A computational approach to edge detection. IEEE Tran Pattern Anal and Mach Intell 6:679–698, 1986
Haykin S: Neural networks and learning machines. Prentice-Hall, Englewood Cliffs, 2009
Theera-Umpon N: White blood cell segmentation and classification in microscopic bone marrow images. Lect Notes Comput Sci 3614:787–792, 2005
Beauchemin M, Thomson KPB, Edwards G: On the Hausdorff distance used for the evaluation of segmentation results. Canadian Journal of Remote Sensing 24(1):3–8, 1998
Acknowledgements
The authors would like to thank the Office of the Higher Education Commission, Thailand, for supporting by grant fund under the Strategic Scholarships for Frontier Research Network for the Ph.D. Program. We would like to thank Dr. Wichai Kultangwattana from the Medical School, Chiang Mai University, and Dr. Pimpaporn Pattarakittitada from the Nongbualamphu Hospital for the segmentation ground truth of the carpal bone images used in this research.
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Somkantha, K., Theera-Umpon, N. & Auephanwiriyakul, S. Bone Age Assessment in Young Children Using Automatic Carpal Bone Feature Extraction and Support Vector Regression. J Digit Imaging 24, 1044–1058 (2011). https://doi.org/10.1007/s10278-011-9372-3
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DOI: https://doi.org/10.1007/s10278-011-9372-3