Skip to main content

Advertisement

SpringerLink
Log in

IgA nephropathy associated with leukemia and lymphoma: report of two cases

  • Case Report
  • Published:
Clinical and Experimental Nephrology Aims and scope Submit manuscript

Abstract

IgA nephropathy (IgAN) associated with leukemia and lymphoma has not, to our knowledge, been reported in children. Two children suffering from these diseases are described here. One patient developed IgAN at the end of 5 years’ chemotherapy for acute lymphocytic leukemia. The other had microscopic hematuria 3 years before the onset of non-Hodgkin lymphoma, and hematuria continued during chemotherapy. Each disease occurred after a long interval, and the clinical courses did not run parallel. The association was thought to be incidental in our cases. Chemotherapy with adrenocorticosteroids and immunosuppressants [6-mercaptopurine (6-MP) and cyclophosphamide (CY)] for leukemia and lymphoma did not affect the clinical course of IgAN.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Ceres F, Rivera F, Yague JL, Blanco J, Garcia-Rojo M, de la Nieta MDS, et al. Non-Hodgkin lymphoma, IgA nephropathy and renal cell carcinoma. Nefrologia 2003;23:554–7.

    CAS  PubMed  Google Scholar 

  2. Bergmann J, Buchheidt D, Waldherr R, Maywald O, van der Woude FJ, Hehlmann R, et al. IgA nephropathy and Hodgkin’s disease: a rare coincidence. Case report and literature review. Am J Kidney Dis 2005;45:e16–9.

    Article  PubMed  Google Scholar 

  3. Iwata Y, Wada T, Uchiyama A, Miwa A, Nakaya I, Tohyama T, et al. Remission of IgA nephropathy after allogeneic peripheral blood stem cell transplantation followed by immunosuppression for acute lymphocytic leukemia. Intern Med 2006;45:1291–5.

    Article  PubMed  Google Scholar 

  4. Mak SK, Wong P-N, Lo K-Y, Wong AKM. Successful treatment of IgA nephropathy in association with low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue type. Am J Kidney Dis 1998;31:713–8.

    Article  CAS  PubMed  Google Scholar 

  5. Cherubini C, Barbera G, Giulio SD, Muda AO, Faraggiana T. Lymphomas and IgA nephropathy. Nephrol Dial Transplant 2001;16:1722–3.

    Article  CAS  PubMed  Google Scholar 

  6. Moe SM, Baron JM, Coventry S, Dolan C, Umans JG. Glomerular disease and urinary Sėzary cells in cutaneous T-cell lymphomas. Am J Kidney Dis 1993;21:545–7.

    Article  CAS  PubMed  Google Scholar 

  7. Ramirez G, Stinson JB, Zawada ET, Moatamed F. IgA nephritis associated with mycosis fungoides. Report of two cases. Arch Intern Med 1981;141:1287–91.

    Article  CAS  PubMed  Google Scholar 

  8. Kimura S, Horie A, Hiki Y, Yamamoto C, Suzuki S, Kuroda J, et al. Nephrotic syndrome with crescent formation and massive IgA deposition following allogeneic bone marrow transplantation for natural killer cell leukemia/lymphoma. Blood 2003;101:4219–21.

    Article  CAS  PubMed  Google Scholar 

  9. Yoshikawa N, White RHR. IgA nephropathy. In: Holliday MA, Barratt TM, Avner ED, editors. Pediatric nephrology. 3rd edn. Baltimore: Williams and Wilkins; 1993. p. 719–28.

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Toho University Medical Center, Sakura Hospital, 564-1 Shimoshizu, Sakura, Chiba, 285-8741, Japan

    Osamu Motoyama

  2. Department of Pediatrics, Toho University Medical Center, Omori Hospital, Tokyo, Japan

    Yasuko Kojima, Akira Ohara & Ichirou Tsukimoto

  3. Department of Pathology, Toho University Medical Center, Omori Hospital, Tokyo, Japan

    Yukio Ishikawa

  4. Department of Pediatrics, International University of Health and Welfare, Atami Hospital, Shizuoka, Japan

    Kikuo Iitaka

Authors
  1. Osamu Motoyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasuko Kojima
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Akira Ohara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ichirou Tsukimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yukio Ishikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kikuo Iitaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Osamu Motoyama.

About this article

Cite this article

Motoyama, O., Kojima, Y., Ohara, A. et al. IgA nephropathy associated with leukemia and lymphoma: report of two cases. Clin Exp Nephrol 12, 140–143 (2008). https://doi.org/10.1007/s10157-007-0009-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10157-007-0009-2

Keywords

Search

Navigation