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Association of TNFα−308, IFNγ+874, and IL10−1082 gene polymorphisms and the risk of non-small cell lung cancer in the population of the South Indian state of Telangana

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Abstract

Background

Cytokine-mediated inflammation is important in the pathogenesis of non-small cell lung cancer (NSCLC). Genetic polymorphisms in cytokine genes and their association with lung cancer in the Indian population have not been reported.

Methods

For the first time, we analyzed genetic polymorphisms of TNFα −308, IFNγ +874, and IL10 −1082 genes in 246 NSCLC patients and 250 healthy controls in the South Indian population from Telangana using ARMS PCR.

Results

IFNγ+874 A/T and IL10−1082 G/G gene polymorphisms were found to be significantly associated with NSCLC with 1.56- and 1.68-fold disease risk, respectively. There was no association between the risk of NSCLC and TNFα−308 polymorphism. Gene polymorphisms stratified according to smoking revealed that IFNγ+874 A/T polymorphisms in smokers increased the disease risk by 2.91 fold. IL10−1082 G/G polymorphisms showed 2-fold increased risk among patients who were smokers when compared to the controls. However, there was no association between TNFα−308, IFNγ+874, and IL10−1082 gene polymorphism and the stage of the NSCLC patients. The overall risk associated with the combination of these polymorphisms indicated that the TNFα−308 G/A + IFNγ+874 A/T + IL10−1082 G/G genotype increased the risk by 1.5 fold.

Conclusions

The results of our study indicate an association between cytokine gene polymorphisms and the risk of NSCLC in an Indian population.

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Acknowledgments

The authors thank all the study subjects who voluntarily participated in the study. They also thank the Director, Institute of Genetics, for providing the necessary infrastructure to carry out the study.

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Author notes

  1. Vidyullatha Peddireddy

    Present address: Department of Biotechnology and Bioinformatics, University of Hyderabad, Gachibowli, Hyderabad, 500046, Telangana, India

Authors and Affiliations

  1. Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500016, Telangana, India

    Vidyullatha Peddireddy, Siva Prasad Badabagni, Venkata Karunakar Kolla & Hemaprasad Mundluru

  2. Bhagwan Mahavir Medical and Research Centre, Hyderabad, 500004, Telangana, India

    Shehnaz Sulthana

  3. Indo-American Cancer Hospital, Banjara Hills, Hyderabad, 500034, Telangana, India

    Sandhya Devi Gundimeda

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  1. Vidyullatha Peddireddy
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Correspondence to Vidyullatha Peddireddy.

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Peddireddy, V., Badabagni, S.P., Sulthana, S. et al. Association of TNFα−308, IFNγ+874, and IL10−1082 gene polymorphisms and the risk of non-small cell lung cancer in the population of the South Indian state of Telangana. Int J Clin Oncol 21, 843–852 (2016). https://doi.org/10.1007/s10147-016-0972-2

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  • DOI: https://doi.org/10.1007/s10147-016-0972-2

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