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Significance of preoperative butyrylcholinesterase as an independent predictor of biochemical recurrence-free survival in patients with prostate cancer treated with radical prostatectomy

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Abstract

Background

Butyrylcholinesterase (BChE) is an alpha-glycoprotein found in the nervous system and liver. Its serum level is reduced in many clinical conditions, such as liver damage, inflammation, injury, infection, malnutrition, and malignant disease. In this study, we analyzed the potential prognostic significance of preoperative BChE levels in patients with prostate cancer (PCa) undergoing radical prostatectomy (RP).

Methods

We retrospectively evaluated 535 patients with PCa who underwent RP from 1996−2014 at a single institution. Serum BChE was routinely measured in all patients before operation. Covariates included age, preoperative laboratory data [prostate-specific antigen (PSA), hemoglobin, total protein, albumin, BChE, lactate dehydrogenase, C-reactive protein], clinical T, biopsy Gleason score, D’Amico risk classification, and RP with/without neoadjuvant therapy. Univariate and multivariate analyses were performed to identify clinical factors associated with biochemical recurrence-free survival (BRFS). Univariate analyses were performed using the Kaplan–Meier and log-rank methods, and multivariate analysis was performed using a Cox proportional hazard model.

Results

The median BChE level was 255 U/L (normal range 168–470 U/L). The median age of the enrolled patients was 68 years, and the median PSA level at diagnosis of PCa was 8.39 ng/mL. The median follow-up period was 65 months. The 5-year BRFS rate was 72.9 %. The 5-year BRFS rates in the BChE ≥168 and ≤ 167 U/L groups were 77.7 and 55.0 %, respectively (P < 0.001). In univariate analysis, BChE, cT, biopsy Gleason score, and D’Amico risk classification were significantly associated with BRFS. Multivariate analysis revealed that BChE was significantly associated with BRFS.

Conclusions

This study validated preoperative serum BChE levels as an independent prognostic factor for PCa after RP.

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References

  1. Huang GJ, Stein JP (2007) Open radical cystectomy with lymphadenectomy remains the treatment of choice for invasive bladder cancer. Curr Opin Urol 17:369–375

    Article  PubMed  Google Scholar 

  2. Makarov DV, Trock BJ, Humphreys EB et al (2007) Updated nomogram to predict pathologic stage of prostate cancer given prostate-specific antigen level, clinical stage, and biopsy Gleason score (Partin tables) based on cases from 2000 to 2005. Urology 69:1095–1101

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kattan MW, Vickers AJ, Yu C et al (2009) Preoperative and postoperative nomograms incorporating surgeon experience for clinically localized prostate cancer. Cancer 115:1005–1010

    Article  PubMed  PubMed Central  Google Scholar 

  4. Yoneyama T, Ohyama C, Hatakeyama S et al (2014) Measurement of aberrant glycosylation of prostate specific antigen can improve specificity in early detection of prostate cancer. Biochem Biophys Res Commun 1448:390–396

    Article  Google Scholar 

  5. Lazzeri M, Haese A, Abrate A et al (2013) Clinical performance of serum prostate-specific antigen isoform [-2]proPSA (p2PSA) and its derivatives, %p2PSA and the prostate health index (PHI), in men with a family history of prostate cancer: results from a multicentre European study, the PROMEtheuS project. BJU Int 112:313–321

    Article  CAS  PubMed  Google Scholar 

  6. Santarpia L, Alfonsi L, Pasanisi F et al (2006) Predictive factors of survival in patients with peritoneal carcinomatosis on home parenteral nutrition. Nutrition 22:355–360

    Article  PubMed  Google Scholar 

  7. Lampón N, Hermida-Cadahia EF, Riveiro A et al (2012) Association between butyrylcholinesterase activity and low-grade systemic inflammation. Ann Hepatol 11:356–363

    PubMed  Google Scholar 

  8. Chougule A, Hussain S, Agarwal DP (2008) Prognostic and diagnostic value of serum pseudocholinesterase, serum aspartate transaminase and serum alanine transaminase in malignancies treated by radiotherapy. J Cancer Res Ther 4:21–25

    Article  CAS  PubMed  Google Scholar 

  9. Koie T, Ohyama C, Yamamoto H et al (2014) Significance of preoperative butyrylcholinesterase as an independent predictor of survival in patients with muscle-invasive bladder cancer treated with radical cystectomy. Urol Oncol 32:820–825

    Article  CAS  PubMed  Google Scholar 

  10. Mitsunaga S, Kinoshita T, Hasebe T et al (2008) Low serum level of cholinesterase at recurrence of pancreatic cancer is a poor prognostic factor and relates to systemic disorder and nerve plexus invasion. Pancreas 36:241–248

    Article  CAS  PubMed  Google Scholar 

  11. D’Amico AV, Whittington R, Malkowicz SB et al (1998) Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA 280:969–974

    Article  PubMed  Google Scholar 

  12. Koie T, Yamamoto H, Hatakeyama S et al (2011) Minimum incision endoscopic radical prostatectomy: clinical and oncological outcomes at a single institute. Eur J Surg Oncol 37:805–810

    Article  CAS  PubMed  Google Scholar 

  13. Epstein JI, Allsbrook WC Jr, Amin MB et al (2005) The 2005 International society of urological pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma. Am J Surg Pathol 29:1228–1242

    Article  PubMed  Google Scholar 

  14. Urinary Bladder (2010) In: Edge SB, Byrd DR, Compton CC, Frits AG, Greene FL, Trotti A (eds) AJCC cancer staging manual, 7th edn. Springer, New York, pp 497–505

  15. Kinoshita S, Toyofuku M, Iida H et al (2001) Standardization of laboratory data and establishment of reference intervals in the Fukuoka Prefecture: a Japanese perspective. Clin Chem Lab Med 39:256–262

    Article  CAS  PubMed  Google Scholar 

  16. Santarpia L, Grandone I, Contaldo F et al (2013) Butyrylcholinesterase as a prognostic marker: a review of the literature. J Cachexia Sarcopenia Muscle 4:31–39

    Article  PubMed  PubMed Central  Google Scholar 

  17. Mitrache C, Passwerg JR, Libura J et al (2001) Anemia: an indicator for malnutrition in the elderly. Ann Hematol 80:295–298

    Article  CAS  PubMed  Google Scholar 

  18. Eggers H, Seidel C, Schrader AJ et al (2013) Serum C-reactive protein: a prognostic factor in metastatic urothelial cancer of the bladder. Med Oncol 30:705–711

    Article  PubMed  Google Scholar 

  19. Ogunkeye OO, Roluga AI (2006) Serum cholinesterase activity helps to distinguish between liver disease and non liver disease aberration in liver function tests. Pathophysiology 13:91–93

    Article  CAS  PubMed  Google Scholar 

  20. Chen VP, Gao Y, Geng L et al (2015) Plasma butyrylcholinesterase regulates ghrelin to control aggression. Proc Natl Acad Sci USA 112:2251–2256

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Klok MD, Jakobsdottir S, Drent ML (2006) The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev 8:21–34

    Article  Google Scholar 

  22. Ishizaki F, Hoque MA, Nishiyama T et al (2011) External validation of the UCSF-CAPRA (University of Calfornia, San Francisco, cancer of the prostate risk assessment) in Japanese patients receiving radical prostatectomy. Jpn J Clin Oncol 41:1259–1264

    Article  PubMed  Google Scholar 

  23. Tanaka N, Fujimoto K, Hirayama A et al (2011) Risk-stratified survival rates and prediction of biochemical recurrence after radical prostatectomy in a Nara, Japan, cohort study. Int J Clin Oncol 16:553–559

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Hirosaki University, Graduate School of Medicine, 5 Zaifucho, Hirosaki, 036-8562, Japan

    Takuya Koie, Chikara Ohyama, Shingo Hatakeyama, Atsushi Imai, Takahiro Yoneyama, Yasuhiro Hashimoto, Tohru Yoneyama, Yuki Tobisawa, Shogo Hosogoe & Hayato Yamamoto

  2. Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifucho, Hirosaki, Japan

    Masato Kitayama & Kazuyoshi Hirota

Authors
  1. Takuya Koie
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  2. Chikara Ohyama
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  3. Shingo Hatakeyama
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  4. Atsushi Imai
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  5. Takahiro Yoneyama
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  6. Yasuhiro Hashimoto
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  7. Tohru Yoneyama
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  8. Yuki Tobisawa
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  9. Shogo Hosogoe
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  10. Hayato Yamamoto
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  11. Masato Kitayama
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  12. Kazuyoshi Hirota
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Corresponding author

Correspondence to Takuya Koie.

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Koie, T., Ohyama, C., Hatakeyama, S. et al. Significance of preoperative butyrylcholinesterase as an independent predictor of biochemical recurrence-free survival in patients with prostate cancer treated with radical prostatectomy. Int J Clin Oncol 21, 379–383 (2016). https://doi.org/10.1007/s10147-015-0880-x

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  • DOI: https://doi.org/10.1007/s10147-015-0880-x

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