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Demographic and morphological characteristics associated with rupture status of anterior communicating artery aneurysms

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Abstract

The aim of this study is to characterize demographic and morphologic characteristics of aneurysms located in the anterior communicating artery (ACoA) and to investigate possible associations between these characteristics and aneurysm rupture. We investigated 112 consecutive patients (72 ruptured and 40 unruptured) with ACoA aneurysms from a single-center database. The effects of demographic and morphologic characteristics on the risk of rupture in ACoA aneurysms were tested using univariate and multivariate logistic regression analyses, respectively. We found that larger size, greater size ratio, larger flow angle, irregular shape, and smoking of the patient were associated with the rupture of ACoA aneurysms based on univariate analysis. Size ratio (OR = 3.890, P = 0.003), irregular shape (OR = 1.068, P = 0.001), flow angle (OR = 1.054, P = 0.001), and current smoking (OR = 4.435, P = 0.009) were the strongest factors related to ruptured ACoA aneurysms based on multivariate logistic regression analysis. The areas under the curves for the flow angle and size ratio were 0.742 (95% CI 0.646–0.838; P = 0.001) and 0.736 (95% CI 0.621–0.796; P = 0.001), respectively. The strongest risk factors for rupture include size ratio, irregular shape, flow angle, and current smoking. These features should be taken into consideration to aid in the prediction of the rupture risk of ACoA aneurysms.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Neurosurgery, Beijing Chaoyang Hospital, Capital Medical University, No. 5 Jingyuan Road, Beijing, 100043, China

    Xiangke Ma

  2. Department of Neurosurgery, University Hospital of Zurich, Frauenklinikstrasse 10, CH-8091, Zurich, Switzerland

    Xiangke Ma & Yang Yang

  3. Department of Neuroradiology, Beijing Chaoyang Hospital, Capital Medical University, No. 5, Jingyuan Road, Beijing, 100043, China

    Dongtao Liu, Yiming Zhou & Weihua Jia

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  1. Xiangke Ma
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Correspondence to Xiangke Ma.

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Approval for the retrospective study was obtained from the research ethics committee of Chaoyang Hospital affiliated with the Capital Medical University.

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Ma, X., Yang, Y., Liu, D. et al. Demographic and morphological characteristics associated with rupture status of anterior communicating artery aneurysms. Neurosurg Rev 43, 589–595 (2020). https://doi.org/10.1007/s10143-019-01080-w

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  • DOI: https://doi.org/10.1007/s10143-019-01080-w

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