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Comparative efficacy of topical aloe vera and low-level laser therapy in the management of oral lichen planus: a randomized clinical trial

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Abstract

This randomized clinical trial aimed to compare the efficacy of topical aloe vera with low-level laser therapy in patients with oral lichen planus (OLP). A randomized, parallel arm, single-blind study comprising of 60 patients with OLP was randomly divided into two groups. Group A was given topical aloe vera extract gel applied thrice daily for 2 months, and group B was given low-level laser therapy (LLLT) at 980 nm twice weekly for 2 months. Both groups were followed up for 9 months. Patients were assessed for various parameters according to the Escudier scale at baseline, after treatment at 9 months. Results were assessed using the McNemar-Bowker test and the Mann–Whitney U test. Both individual groups showed significant (p < 0.05) results at the end of the treatment period (0–2 months) and the follow-up period (2–7 months). Intergroup comparison showed significant results in the laser group (reduction of VAS by 44.1%, site score by 24.6%, and activity score by 50%) as compared with the aloe vera group (reduction of VAS by 26.7%, site score by 9.2%, and the activity score by 26%) in the treatment period. In the follow-up period, both groups showed insignificant differences in comparison to each other. Within the limitations of the study, LLLT was more effective as compared with topical aloe vera in managing oral lichen planus during the active treatment time, while both were equally effective during the follow-up period. The clinical study was registered under the Clinical Trials Registry India with the registration number CTRI/2018/04/013147.

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References

  1. Alrashdan MS, Cirillo N, McCullough M (2016) Oral lichen planus: a literature review and update. Arch Dermatol Res 308(8):539–551. https://doi.org/10.1007/s00403-016-1667-2

    Article  PubMed  Google Scholar 

  2. Eisen D, Carrozzo M, Bagan Sebastian JV, Thongprasom K (2005) Number V Oral lichen planus: clinical features and management. Oral Dis 11(6):338–349. https://doi.org/10.1111/j.1601-0825.2005.01142.x

    Article  CAS  PubMed  Google Scholar 

  3. Farhi D, Dupin N (2010) Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies. Clin Dermatol 28(1):100–108. https://doi.org/10.1016/j.clindermatol.2009.03.004

    Article  PubMed  Google Scholar 

  4. Kurago ZB (2016) Etiology and pathogenesis of oral lichen planus: an overview. Oral Surg Oral Med Oral Pathol Oral Radiol 122(1):72–80. https://doi.org/10.1016/j.oooo.2016.03.011

    Article  PubMed  Google Scholar 

  5. Mignogna MD, Fedele S, Lo Russo L, Lo Muzio L, Bucci E (2004) Immune activation and chronic inflammation as the cause of malignancy in oral lichen planus: is there any evidence ? Oral Oncol 40(2):120–130. https://doi.org/10.1016/j.oraloncology.2003.08.001

    Article  PubMed  Google Scholar 

  6. Giuliani M, Troiano G, Cordaro M et al (2019) Rate of malignant transformation of oral lichen planus: a systematic review. Oral Dis 25(3):693–709. https://doi.org/10.1111/odi.12885

    Article  PubMed  Google Scholar 

  7. Gupta S, Ghosh S, Gupta S (2017) Interventions for the management of oral lichen planus: a review of the conventional and novel therapies. Oral Dis 23(8):1029–1042. https://doi.org/10.1111/odi.12634

    Article  CAS  PubMed  Google Scholar 

  8. Escudier M, Ahmed N, Shirlaw P et al (2007) A scoring system for mucosal disease severity with special reference to oral lichen planus. Br J Dermatol 157(4):765–770. https://doi.org/10.1111/j.1365-2133.2007.08106.x

    Article  CAS  PubMed  Google Scholar 

  9. Mergoni G, Magnani V, Goldoni M, Vescovi P, Manfredi M (2019) Effects of oral healthcare motivation in patients with gingival oral lichen planus: a randomized controlled trial. Oral Dis 25(5):1335–1343. https://doi.org/10.1111/odi.13104

    Article  PubMed  Google Scholar 

  10. Kunz M, Urosevic-Maiwald M, Goldinger SM et al (2016) Efficacy and safety of oral alitretinoin in severe oral lichen planus–results of a prospective pilot study. J Eur Acad Dermatol Venereol 30(2):293–298. https://doi.org/10.1111/jdv.13444

    Article  CAS  PubMed  Google Scholar 

  11. Dillenburg CS, Martins MA, Munerato MC et al (2014) Efficacy of laser phototherapy in comparison to topical clobetasol for the treatment of oral lichen planus: a randomized controlled trial. J Biomed Opt 19(6):068002. https://doi.org/10.1117/1.JBO.19.6.068002

    Article  PubMed  Google Scholar 

  12. Misra N, Chittoria N, Umapathy D, Misra P (2013) Efficacy of diode laser in the management of oral lichen planus. BMJ Case Rep. 2013:bcr2012007609. Published 2013 Mar 15. https://doi.org/10.1136/bcr-2012-007609

  13. Varghese SS, George GB, Sarojini SB et al (2016) Epidemiology of oral lichen planus in a cohort of South Indian population: a retrospective study. J Cancer Prev 21(1):55–59. https://doi.org/10.15430/JCP.2016.21.1.55

    Article  PubMed  PubMed Central  Google Scholar 

  14. Lauritano D, Arrica M, Lucchese A, et al (2016) Oral lichen planus clinical characteristics in Italian patients: a retrospective analysis. Head Face Med. 12:18. Published 2016 Apr 26. https://doi.org/10.1186/s13005-016-0115-z

  15. Xue JL, Fan MW, Wang SZ, Chen XM, Li Y, Wang L (2005) A clinical study of 674 patients with oral lichen planus in China. J Oral Pathol Med 34(8):467–472. https://doi.org/10.1111/j.1600-0714.2005.00341.x

    Article  PubMed  Google Scholar 

  16. Salehi B, Lopez-Jornet P, Pons-Fuster López E, et al (2019) Plant-derived bioactives in oral mucosal lesions: a key emphasis to curcumin, lycopene, chamomile, aloe vera, green tea and coffee properties. Biomolecules. 9(3):106. Published 2019 Mar 17. https://doi.org/10.3390/biom9030106

  17. Reddy RL, Reddy RS, Ramesh T, Singh TR, Swapna LA, Laxmi NV (2012) Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus. Quintessence Int 43(9):793–800

    PubMed  Google Scholar 

  18. Mussttaf RA, Jenkins DFL, Jha AN (2019) Assessing the impact of low level laser therapy (LLLT) on biological systems: a review. Int J Radiat Biol 95(2):120–143. https://doi.org/10.1080/09553002.2019.1524944

    Article  CAS  PubMed  Google Scholar 

  19. Cafaro A, Arduino PG, Massolini G, Romagnoli E, Broccoletti R (2014) Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series. Lasers Med Sci 29(1):185–190. https://doi.org/10.1007/s10103-013-1313-6

    Article  PubMed  Google Scholar 

  20. Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P (2008) The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Br J Dermatol 158(3):573–577. https://doi.org/10.1111/j.1365-2133.2007.08370.x

    Article  CAS  PubMed  Google Scholar 

  21. Salazar-Sánchez N, López-Jornet P, Camacho-Alonso F, Sánchez-Siles M (2010) Efficacy of topical aloe vera in patients with oral lichen planus: a randomized double-blind study. J Oral Pathol Med 39(10):735–740. https://doi.org/10.1111/j.1600-0714.2010.00947.x

    Article  PubMed  Google Scholar 

  22. Choi SW, Son BW, Son YS, Park YI, Lee SK, Chung MH (2001) The wound-healing effect of a glycoprotein fraction isolated from aloe vera. Br J Dermatol 145(4):535–545. https://doi.org/10.1046/j.1365-2133.2001.04410.x

    Article  CAS  PubMed  Google Scholar 

  23. Bawankar R, Deepti VC, Singh P, Subashkumar R, Vivekanandhan G, Babu S (2013) Evaluation of bioactive potential of an aloe vera sterol extract. Phytother Res 27(6):864–868. https://doi.org/10.1002/ptr.4827

    Article  CAS  PubMed  Google Scholar 

  24. Elshenawy HM, Eldin AM, Abdelmonem MA (2015) Clinical Assessment of the efficiency of low level laser therapy in the treatment of oral lichen planus. Open Access Maced J Med Sci 3(4):717–721. https://doi.org/10.3889/oamjms.2015.112

    Article  PubMed  PubMed Central  Google Scholar 

  25. Farivar S, Malekshahabi T, Shiari R (2014) Biological effects of low level laser therapy. J Lasers Med Sci 5(2):58–62

    PubMed  PubMed Central  Google Scholar 

  26. Karu TI, Pyatibrat LV, Afanasyeva NI (2005) Cellular effects of low power laser therapy can be mediated by nitric oxide. Lasers Surg Med 36(4):307–314. https://doi.org/10.1002/lsm.20148

    Article  PubMed  Google Scholar 

  27. Akram Z, Abduljabbar T, Vohra F, Javed F (2018) Efficacy of low-level laser therapy compared to steroid therapy in the treatment of oral lichen planus: a systematic review. J Oral Pathol Med 47(1):11–17. https://doi.org/10.1111/jop.12619

    Article  CAS  PubMed  Google Scholar 

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Funding

This study was partially funded by the Indian Council of Medical Research [No.3/2/Jan. 2018/PG-Thesis-HRD (47)].

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Authors and Affiliations

  1. Department of Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India

    Girish Bhatt, Sunita Gupta & Sujoy Ghosh

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  1. Girish Bhatt
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  2. Sunita Gupta
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  3. Sujoy Ghosh
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Correspondence to Girish Bhatt.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Bhatt, G., Gupta, S. & Ghosh, S. Comparative efficacy of topical aloe vera and low-level laser therapy in the management of oral lichen planus: a randomized clinical trial. Lasers Med Sci 37, 2063–2070 (2022). https://doi.org/10.1007/s10103-021-03480-1

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  • DOI: https://doi.org/10.1007/s10103-021-03480-1

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