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Analysis of choroidal thickness in ocular hypertensive patients using enhanced depth imaging optical coherence tomography

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Abstract

This study aimed to compare choroidal thickness between subjects with ocular hypertension (OHT) and normal individuals and explore factors affecting choroidal thickness. This study included 60 untreated newly diagnosed OHT eyes and 60 normal eyes. Choroidal thickness obtained from Cirrus HD-OCT was measured at different locations in the macular and peripapillary regions and compared between the two groups before and after adjusting for potential confounding variables. Regression analysis was performed to figure out factors influencing choroidal thickness. The macular choroidal thickness did not vary significantly between OHT patients and normal controls regardless of locations (all P > 0.05). The average peripapillary choroidal thickness was 167 ± 53 μm in OHT eyes and 185 ± 63 μm in the normal eyes; no significant differences were identified (P = 0.107). Only one of the locations in the temporal area in the OHT group demonstrated significantly thinner peripapillary choroidal thickness as compared to the normal group (P = 0.033). Age was the only significant factor affecting choroidal thickness on multivariate analysis regardless of locations (all P < 0.001). Choroidal thickness of the macular and peripapillary regions in OHT patients is not decreased significantly except one location in the temporal area of the optic disc when comparing with the normal subjects. Anatomic peripapillary choroidal thickness measurements with SD-OCT might be one more tool to track changes in OHT patients.

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Authors and Affiliations

  1. Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, 197 Ruijin Er Road, Shanghai, 200025, China

    Zhongjing Lin, Shouyue Huang & Yisheng Zhong

  2. Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, 197 Ruijin Er Road, Shanghai, 200025, China

    Ping Huang & Lei Guo

  3. Department of Ophthalmology, Nantong Rich Hospital, 2000 Xinghu Avenue, Nantong, Jiangsu, 226010, China

    Hongjun Bian

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Contributions

ZJL and YSZ were involved in study design; ZJL and SYH performed the study; ZJL, PH, and LG took measurements and analyzed the data; ZJL drafted the manuscript; HJB and YSZ reviewed the manuscript.

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Correspondence to Hongjun Bian or Yisheng Zhong.

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The authors declare that they have no competing interests.

Ethical approval

The design of the study was in compliance with the principles of the Declaration of Helsinki, and it was approved by the Ethics Committee of Ruijin Hospital, Shanghai Jiaotong University (Shanghai, China). A photocopy of the ethical approval is accessible in the supplementary materials.

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Written consent forms were obtained for all the participants. A model translated in English could be accessed in the supplementary materials.

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Lin, Z., Huang, S., Huang, P. et al. Analysis of choroidal thickness in ocular hypertensive patients using enhanced depth imaging optical coherence tomography. Lasers Med Sci 33, 111–121 (2018). https://doi.org/10.1007/s10103-017-2349-9

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  • DOI: https://doi.org/10.1007/s10103-017-2349-9

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