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First evidence of the presence of adenovirus type 8 in myocardium of patients with severe idiopathic dilated cardiomyopathy

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Abstract

Previous studies have detected adenovirus and cytomegalovirus (CMV) in cardiac tissue of patients with myocarditis. Therefore, in this study, we investigated the frequency of these viruses, which may be involved in the development of severe dilated cardiomyopathy (DCM). Myocardial tissue from of 23 cardiac transplant candidates with acute idiopathic DCM below the age of 40 years were analyzed by amplification of adenovirus and CMV DNA and subsequent sequencing. Adenovirus was detected in four (17.4%) and CMV in one (4.3%) of the patients. All controls were negative for the presence of both viruses. Our study shows that myocardial infection with adenovirus may play an important role in the pathogenesis of severe DCM and suggests that vaccination against adenovirus might be helpful in decreasing the prevalence of severe idiopathic DCM. This is the first study in which adenovirus type 8 has been detected in the hearts of patients with DCM.

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Funding

This study was funded by Islamic Azad University Pharmaceutical Sciences Branch (Grant number 67M).

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Authors and Affiliations

  1. Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Seyed Mohammad Javad Hosseini

  2. Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Seyed Mohsen Mirhosseini

  3. Department of Oral and Maxillofacial Surgery, School of Dentistry, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran

    Mehdi Taghian

  4. Cardiac Surgery Ward, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Mehrdad Salehi

  5. Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Maryam Moshkani Farahani

  6. Department of Microbiology, Faculty of Advanced Science and Technologies, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

    Fariba Bakhtiari

  7. Department of Immunology, Shahrekord University of Medical Sciences, Shahrekord, Iran

    Masoumeh Ghasemi-Pirbaluti

  8. Department of Physiology and Pharmacology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

    Ehsan Motaghi

Authors
  1. Seyed Mohammad Javad Hosseini
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  2. Seyed Mohsen Mirhosseini
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  3. Mehdi Taghian
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  4. Mehrdad Salehi
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  5. Maryam Moshkani Farahani
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  6. Fariba Bakhtiari
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  7. Masoumeh Ghasemi-Pirbaluti
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  8. Ehsan Motaghi
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Corresponding author

Correspondence to Ehsan Motaghi.

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All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

Additional information

Handling Editor: T. K. Frey.

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Hosseini, S.M.J., Mirhosseini, S.M., Taghian, M. et al. First evidence of the presence of adenovirus type 8 in myocardium of patients with severe idiopathic dilated cardiomyopathy. Arch Virol 163, 2895–2897 (2018). https://doi.org/10.1007/s00705-018-3942-3

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  • DOI: https://doi.org/10.1007/s00705-018-3942-3

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