Abstract
Coxsackievirus B5 (CVB5) is a member of the species Enterovirus B of the genus Enterovirus, family Picornaviridae. Based on its VP1 sequence, CVB5 is divided into four genogroups: A, B, C, and D. From 2002 to 2012, CVB5 serotype genogroup C caused an outbreak of aseptic meningitis in China. In order to study the evolution of CVB5 genogroup C, phylogenetic and recombination analysis was performed using the 399 available enterovirus B genome sequences in the GenBank database. The results indicated that 10 strains of CVB5 serotype genogroup C resulted from recombination between members of genogroup B and echovirus serotype E6, and another 5 strains resulted from recombination between members of genogroup C and serotype CVB4. These recombination events were confirmed by phylogenetic analysis.
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This study was funded by China Postdoctoral Science Foundation (2016M591790) and Jiangsu Province Postdoctoral Science Foundation (1601072C).
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Shen, H. Recombination analysis of coxsackievirus B5 genogroup C. Arch Virol 163, 539–544 (2018). https://doi.org/10.1007/s00705-017-3608-6
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DOI: https://doi.org/10.1007/s00705-017-3608-6