Abstract
The effect of d-cycloserine, a N-methyl-d-aspartate receptor partial agonist, on the reconsolidation of conditioned fear memory is not precisely understood. In this study, we clarified the effects of d-cycloserine on the reconsolidation in rats, by performing contextual fear conditioning with a mild fear-conditioning procedure and with post-reexposure administration of the drug. The d-cycloserine (15 mg/kg subcutaneously)-treated rats showed a persistent and greater fear response during the test session compared with the control group. In conclusion, we have confirmed that post-reexposure administration of d-cycloserine facilitates the reconsolidation of fear memory in rats.
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Acknowledgements
This research was supported by an Intramural Research Grant (27-1) for Neurological and Psychiatric Disorders funded by the National Center of Neurology and Psychiatry, Tokyo, Japan.
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Saitoh, A., Akagi, K., Oka, JI. et al. Post-reexposure administration of d-cycloserine facilitates reconsolidation of contextual conditioned fear memory in rats. J Neural Transm 124, 583–587 (2017). https://doi.org/10.1007/s00702-017-1704-0
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DOI: https://doi.org/10.1007/s00702-017-1704-0