Abstract
Although liposarcomas are the most common soft tissue sarcomas, their intracranial variants are extremely rare. Here, we present a case of a primary intracranial myxoid liposarcoma in a 23-year-old Japanese man who presented with generalized seizures and a mass in the left frontal lobe. The tumor was totally removed, and histological analyses pointed to liposarcoma. Thirteen years after his initial treatment, the patient presented with right-side weakness and local recurrence of tumor was discovered. Histology from the second resection confirmed the diagnosis of myxoid liposarcoma. Shortly after the second resection, progressive, new intracranial lesions were observed and despite a third resection, extensive intracerebral invasion by the tumor proved fatal. The histological features of myxoid liposarcoma were essentially similar with each recurrence, but the aggressive tumor behavior after the second operation did not align with expectations based on histological classification.
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References
Antonescu CR, Paulus W, Perry A, Rushing EJ, Hainfellner JA, Bouvier C, Figarella-Branger D, von Deiming A, Wesseling P (2016) WHO classification of tumours of the central nervous system. IARC, Lyon
Cinalli G, Zerah M, Carteret M, Doz F, Vinikoff L, Lellouch-Tubiana A, Husson B, Pierre-Kahn A (1997) Subdural sarcoma associated with chronic subdural hematoma. Report of two cases and review of the literature. J Neurosurg 86:553–557
Crago AM, Dickson MA (2016) Liposarcoma: multimodality management and future targeted therapies. Surg Oncol Clin N Am 25:761–773
Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F (2013) WHO classification of tumours of soft tissue and bone. IARC, Lyon
Garciaz S, Bouvier C, Roche PH, Salas S (2012) Primary dediffentiated liposarcoma of the dura mater: case report. Acta Neurochir 154:1737–1738
Kothandaram P (1970) Dural liposarcoma associated with subdural hematoma. Case report. J Neurosurg 33:85–87
Mumert ML, Walsh MT, Jensen EM, Jensen RL (2010) Pleomorphic liposarcoma originating from intracranial dura mater. J Neuro-Oncol 97:149–153
Murphey MD, Arcara LK, Fanburg-Smith J (2005) From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics 25:1371–1395
Sima A, Kindblom LG, Pellettieri L (1976) Liposarcoma of the meninges. A case report. Acta Pathol Microbiol Scand A 84:306–310
Sivaraju L, Aryan S, Siddappa AK, Ghosal N, Hegde AS (2015) Primary tentorial liposarcoma. Clin Neuropathol 34:364–367
Acknowledgements
We are grateful to Dr. K. Oka for the primary pathological diagnosis, Dr. I. Emura (Niigata University Hospital) for the helpful suggestions for the diagnosis, and Dr. M. Ito (Shimura Hospital) for supplying clinical data after the third operation. We also thank Dr. Bryan J. Mathis of the University of Tsukuba Medical English Communication Center for the native English language revision.
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This manuscript was submitted to and approved by the ethics committee of Mito Saiseikai General Hospital.
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Informed consent was obtained from the patient included in the study.
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This article is part of the Topical Collection on Brain Tumors
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Watanabe, N., Ohtani, H., Mori, S. et al. Primary meningeal myxoid liposarcoma with aggressive behavior after recurrence: case report. Acta Neurochir 160, 1557–1561 (2018). https://doi.org/10.1007/s00701-018-3598-5
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DOI: https://doi.org/10.1007/s00701-018-3598-5